PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27121751-7 2016 For those that do, incorporation of 5"-(E)-vinylphosphonate (5"-VP), a metabolically stable phosphate mimic, results in up to 20-fold improved in vitro potency and up to a threefold benefit in in vivo activity by promoting Ago2 loading and enhancing metabolic stability. 5"-vp 61-66 argonaute RISC catalytic component 2 Homo sapiens 223-227