PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33730072-6	2021	Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways.	Radium	22-24	tumor necrosis factor	Homo sapiens	53-62	
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	tumor necrosis factor	Homo sapiens	50-53	
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	tumor necrosis factor	Homo sapiens	82-85	
33730072-9	2021	These results suggest that 13-cis RA and 1,25-VD3 significantly suppress TNF-alpha mediated cell invasion and therefore potentially act as preventive agents against PDAC.	Radium	34-36	tumor necrosis factor	Homo sapiens	73-82	
20001643-1	2010	The aim of this study was to describe how persons with RA from an area in western Sweden experience everyday life with TNF-alpha blockers.	Radium	55-57	tumor necrosis factor	Homo sapiens	119-128	
30753643-0	2019	Has TNF inhibitor use decreased the need for total hip and total knee replacement for patients with RA?	Radium	100-102	tumor necrosis factor	Homo sapiens	4-7	
30289535-4	2018	The increasing use of TNF inhibitors has not only improved the management of RA, but it has also helped in our understanding of the pathogenetic mechanisms of the disease.	Radium	77-79	tumor necrosis factor	Homo sapiens	22-25	
22155198-4	2012	In RA synovial tissue, biological effects of these metabolites as a consequence of altered peripheral sex hormone synthesis (intracrine, e.g., at the level of macrophages and fibroblasts) mainly results in stimulation of cell proliferation and cytokine production (i.e. TNF).	Radium	3-5	tumor necrosis factor	Homo sapiens	270-273	
22500176-4	2012	To study literature evidence assessing the risk of surgical site infections in orthopedic surgery patients with RA using anti-TNF drugs, compared to untreated patients or those using conventional DMARD.	Radium	112-114	tumor necrosis factor	Homo sapiens	126-129	
21873267-11	2011	CONCLUSIONS: Scintigraphy using (99m)Tc-anti-TNF-alpha showed high correlation with the presence of inflammatory signs detected by MRI in the hands and wrists of patients with active RA, and demonstrated a greater sensitivity than clinical examination.	Radium	183-185	tumor necrosis factor	Homo sapiens	45-54	
29696196-2	2017	Recent studies indicated that baseline serum TNF-alpha could be considered as a key indicator for optimal dosing of infliximab for RA treatment to achieve the clinical response and its sustained remission.	Radium	131-133	tumor necrosis factor	Homo sapiens	45-54	
23882111-1	2014	RA is characterized by chronic inflammation in the musculoskeletal system, in which TNF-alpha is the key cytokine trigger.	Radium	0-2	tumor necrosis factor	Homo sapiens	84-93	
24373564-3	2013	CASE PRESENTATION: We present the case of a 40-year-old woman, with a confirmed erosive and seropositive RA, successfully treated by TNFalpha blocker (etanercept) for seven years, and who developed a severe neurosarcoidosis.	Radium	105-107	tumor necrosis factor	Homo sapiens	133-141	
22847212-2	2012	BACKGROUND: The chance of a good response in RA is attenuated in previous anti-TNF users who start new anti-TNF therapy compared to biologic naive patients.	Radium	45-47	tumor necrosis factor	Homo sapiens	79-82	
22847212-2	2012	BACKGROUND: The chance of a good response in RA is attenuated in previous anti-TNF users who start new anti-TNF therapy compared to biologic naive patients.	Radium	45-47	tumor necrosis factor	Homo sapiens	108-111	
15989786-6	2005	CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines.	Radium	12-14	tumor necrosis factor	Homo sapiens	86-95	
19999184-14	2009	The efficacy, safety, and quality of life benefits of TNFalpha antagonists suggest using them possibly earlier than today, even in clinically moderate RA.	Radium	151-153	tumor necrosis factor	Homo sapiens	54-62	
9022083-3	1997	To determine modes of retinoid action in the modulation of inflammatory responses, we explored effects of all-trans-retinoic acid (t-RA) on the TNFalpha-induced expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin in cultured human dermal microvascular endothelial cells.	Radium	133-135	tumor necrosis factor	Homo sapiens	144-152	
12889993-4	2003	It appeared that DQCARII*194/DRB1*0405/TNFa*117 was part of the extended haplotype predisposed to RA, whereas DRB1*0901/D6S273*128 contributed to susceptibility to RA to a lesser degree in Singaporean Chinese.	Radium	98-100	tumor necrosis factor	Homo sapiens	39-43	
12889993-4	2003	It appeared that DQCARII*194/DRB1*0405/TNFa*117 was part of the extended haplotype predisposed to RA, whereas DRB1*0901/D6S273*128 contributed to susceptibility to RA to a lesser degree in Singaporean Chinese.	Radium	164-166	tumor necrosis factor	Homo sapiens	39-43	
11694593-7	2001	TNF-alpha, sphingomyelinase, and C(2)-ceramide translocated Cdc42, Rac, and RhoA to membranes, and stimulated p21-activated protein kinase downstream of Ras-GTP, PI 3-K, and SK.	Radium	153-156	tumor necrosis factor	Homo sapiens	0-9	
15695534-2	2005	MATERIALS AND METHODS: The South Swedish Arthritis Treatment Group register (SSATG) comprises over 90% of anti-TNF treated patients with RA in the area.	Radium	137-139	tumor necrosis factor	Homo sapiens	111-114	
12810424-6	2003	Serum concentrations of TNFalpha were, within the RA group, inversely correlated with blood flow responses to both SNP (r=-0.67, p=0.002) and ACh (r=-0.64, p<0.005).	Radium	50-52	tumor necrosis factor	Homo sapiens	24-32	
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	tumor necrosis factor	Homo sapiens	51-60	
7805163-3	1994	The results showed that IL-1 Growth Index (GI) and TNF-alpha Killing Rate (KR) in RA group are higher than in non-synovitis group (negative control) with statistically significant difference and that the cultured time of the IL-1 highest value is consistent with TNF-alpha.	Radium	82-84	tumor necrosis factor	Homo sapiens	263-272	
34474187-13	2021	In addition, 29 signaling pathways were found to be involved in RA-RRM-induced amelioration, including the NF-kappaB, TNF, TGF-beta, VEGF, and HIF-1 signaling pathways, using KEGG analysis.	Radium	64-66	tumor necrosis factor	Homo sapiens	118-121