PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12061540-0	2002	In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes.	Ketoconazole	55-67	Cytochrome P450 1A1	Canis lupus familiaris	95-111	
12061540-1	2002	OBJECTIVE: To evaluate the inhibitory potency of ketoconazole (KTZ) on the metabolic activities of isozymes of cytochrome P-450 (CYP) in dogs.	Ketoconazole	49-61	Cytochrome P450 1A1	Canis lupus familiaris	111-127	
12061540-1	2002	OBJECTIVE: To evaluate the inhibitory potency of ketoconazole (KTZ) on the metabolic activities of isozymes of cytochrome P-450 (CYP) in dogs.	Ketoconazole	49-61	Cytochrome P450 1A1	Canis lupus familiaris	129-132	
12061540-1	2002	OBJECTIVE: To evaluate the inhibitory potency of ketoconazole (KTZ) on the metabolic activities of isozymes of cytochrome P-450 (CYP) in dogs.	Ketoconazole	63-66	Cytochrome P450 1A1	Canis lupus familiaris	111-127	
12061540-1	2002	OBJECTIVE: To evaluate the inhibitory potency of ketoconazole (KTZ) on the metabolic activities of isozymes of cytochrome P-450 (CYP) in dogs.	Ketoconazole	63-66	Cytochrome P450 1A1	Canis lupus familiaris	129-132	
12061540-4	2002	To investigate the effects of KTZ on CYP metabolic activities, 7-ethoxyresorufin, tolbutamide, bufuralol, and midazolam hydrochloride were used as specific substrates for CYP1A1/2, CYP2C21, CYP2D15, and CYP3A12, respectively.	Ketoconazole	30-33	Cytochrome P450 1A1	Canis lupus familiaris	37-40	
12061540-4	2002	To investigate the effects of KTZ on CYP metabolic activities, 7-ethoxyresorufin, tolbutamide, bufuralol, and midazolam hydrochloride were used as specific substrates for CYP1A1/2, CYP2C21, CYP2D15, and CYP3A12, respectively.	Ketoconazole	30-33	Cytochrome P450 1A1	Canis lupus familiaris	171-177	
1901255-4	1991	The cytochrome P-450 inhibitors ketoconazole (10 and 100 microM) and beta-diethyl-aminoethyldiphenylpropylacetate (SKF 525A, 10 and 100 microM) also inhibited the myogenic response.	Ketoconazole	32-44	Cytochrome P450 1A1	Canis lupus familiaris	4-20