PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24438818-17 2014 (68)Ga-DOTA-NGR could also specifically bind to the APN receptor in vitro and in vivo, and might be a potential molecular probe for the noninvasive detection of APN-positive tumors and neovasculature. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 7-11 alanyl aminopeptidase, membrane Homo sapiens 52-55 24438818-17 2014 (68)Ga-DOTA-NGR could also specifically bind to the APN receptor in vitro and in vivo, and might be a potential molecular probe for the noninvasive detection of APN-positive tumors and neovasculature. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 7-11 alanyl aminopeptidase, membrane Homo sapiens 161-164 23190134-8 2013 For small animal microPET studies, (64)Cu-DOTA-NGR2 displayed more favorable in vivo performance in terms of higher tumor uptake and slower tumor washout in CD13-positive HT-1080 tumor xenografts as compared to (64)Cu-DOTA-NGR1. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 39-46 alanyl aminopeptidase, membrane Homo sapiens 157-161 23190134-9 2013 As expected, significantly lower tumor uptake and poorer tumor/normal organ contrast were observed for both (64)Cu-DOTA-NGR1 and (64)Cu-DOTA-NGR2 in CD13-negative HT-29 tumor xenografts in comparison with those in the HT-1080 tumor xenografts. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 133-140 alanyl aminopeptidase, membrane Homo sapiens 149-153 23190134-10 2013 The CD13-specific tumor activity accumulation of both (64)Cu-DOTA-NGR1 and (64)Cu-DOTA-NGR2 was further demonstrated by significant reduction of tumor uptake in HT-1080 tumor xenografts with a coinjected blocking dose of cyclic NGR peptide [c(CNGRC)]. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 58-65 alanyl aminopeptidase, membrane Homo sapiens 4-8 23190134-10 2013 The CD13-specific tumor activity accumulation of both (64)Cu-DOTA-NGR1 and (64)Cu-DOTA-NGR2 was further demonstrated by significant reduction of tumor uptake in HT-1080 tumor xenografts with a coinjected blocking dose of cyclic NGR peptide [c(CNGRC)]. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 79-86 alanyl aminopeptidase, membrane Homo sapiens 4-8 23190134-12 2013 We concluded that both (64)Cu-DOTA-NGR1 and (64)Cu-DOTA-NGR2 have good and specific tumor uptake in CD13-positive HT-1080 tumor xenografts. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 27-34 alanyl aminopeptidase, membrane Homo sapiens 100-104 23190134-12 2013 We concluded that both (64)Cu-DOTA-NGR1 and (64)Cu-DOTA-NGR2 have good and specific tumor uptake in CD13-positive HT-1080 tumor xenografts. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 48-55 alanyl aminopeptidase, membrane Homo sapiens 100-104 23190134-14 2013 (64)Cu-DOTA-NGR2 is a promising PET probe for noninvasive detection of CD13 receptor expression in vivo. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 4-11 alanyl aminopeptidase, membrane Homo sapiens 71-75