PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33829974-5 2021 Free bilirubin can also function as an agonist for the aryl hydrocarbon receptor (AhR); this may explain its ability to promote protective Treg activity in cellular and rodent models of inflammatory disease. Bilirubin 5-14 aryl hydrocarbon receptor Homo sapiens 55-80 19356098-0 2008 Induction of human UGT1A1 by bilirubin through AhR dependent pathway. Bilirubin 29-38 aryl hydrocarbon receptor Homo sapiens 47-50 19356098-2 2008 In this report, we show findings of the induction of the reporter gene (-3475/+14) of UGT1A1 in HepG2 cells by bilirubin at 50 microM, 100 microM, with human aryl hydrocarbon receptor (hAhR). Bilirubin 111-120 aryl hydrocarbon receptor Homo sapiens 158-183 19356098-2 2008 In this report, we show findings of the induction of the reporter gene (-3475/+14) of UGT1A1 in HepG2 cells by bilirubin at 50 microM, 100 microM, with human aryl hydrocarbon receptor (hAhR). Bilirubin 111-120 aryl hydrocarbon receptor Homo sapiens 185-189 19356098-6 2008 These results indicate that the induction of UGT1A1 by bilirubin-AhR did not depend on the elevation of AhR but on ligand binding. Bilirubin 55-64 aryl hydrocarbon receptor Homo sapiens 65-68 19356098-8 2008 This is the first report showing direct induction of UGT1A1 by a bilirubin through AhR pathway. Bilirubin 65-74 aryl hydrocarbon receptor Homo sapiens 83-86 20370320-0 2010 Contributions of the Ah receptor to bilirubin homeostasis and its antioxidative and atheroprotective functions. Bilirubin 36-45 aryl hydrocarbon receptor Homo sapiens 21-32 20370320-1 2010 Abstract The homeostasis and atheroprotective function of bilirubin could be an appealing model to investigate one of the many physiologic functions of the human aryl hydrocarbon receptor (AhR). Bilirubin 58-67 aryl hydrocarbon receptor Homo sapiens 162-187 20370320-1 2010 Abstract The homeostasis and atheroprotective function of bilirubin could be an appealing model to investigate one of the many physiologic functions of the human aryl hydrocarbon receptor (AhR). Bilirubin 58-67 aryl hydrocarbon receptor Homo sapiens 189-192 20370320-2 2010 Several clinical and epidemiological studies have been carried out on key enzymes generating and eliminating bilirubin (heme oxygenase-1 and UDP-glucuronosyltransferase UGT1A1, respectively) and their regulation by the AhR. Bilirubin 109-118 aryl hydrocarbon receptor Homo sapiens 219-222 20370320-5 2010 The strong antioxidant and activator of AhR bilirubin is generated in vascular endothelial cells, smooth muscles and macrophages. Bilirubin 44-53 aryl hydrocarbon receptor Homo sapiens 40-43 20370320-7 2010 In conclusion, the atheroprotective functions of bilirubin might not only provide models to study physiologic functions of the human AhR but also provide opportunities to improve prevention and treatment of a major life-threatening disease. Bilirubin 49-58 aryl hydrocarbon receptor Homo sapiens 133-136 19831498-7 2010 In addition and similar to observations with CYPs, UGTs may be responsible for homeostatic control of AhR ligands, such as bilirubin, a fruitful area to be studied in the future. Bilirubin 123-132 aryl hydrocarbon receptor Homo sapiens 102-105 19831728-5 2010 In the present review, we will discuss i) how bilirubin reduces its circulating levels by activating AhR in the liver; ii) how bile acids modulate their hepatic glucuronidation via PXR- and FXR-dependent processes in enterohepatic tissues; and iii) how androgens inhibit their cellular metabolism in prostate cancer cells through an AR-dependent mechanism. Bilirubin 46-55 aryl hydrocarbon receptor Homo sapiens 101-104 19747074-6 2009 Homeostatic feedback loops might not only include CYP1A1 but also Phase II enzymes such as UGT1A1 which controls the antioxidant AhR ligand bilirubin. Bilirubin 140-149 aryl hydrocarbon receptor Homo sapiens 129-132 33829974-5 2021 Free bilirubin can also function as an agonist for the aryl hydrocarbon receptor (AhR); this may explain its ability to promote protective Treg activity in cellular and rodent models of inflammatory disease. Bilirubin 5-14 aryl hydrocarbon receptor Homo sapiens 82-85 31693091-9 2020 Administration of APT102 in vivo enhanced the beneficial effects of endogenous Cd39 boosted by the administration of the aryl-hydrocarbon-receptor (AhR) ligand unconjugated bilirubin (UCB). Bilirubin 173-182 aryl hydrocarbon receptor Homo sapiens 121-146 31693091-9 2020 Administration of APT102 in vivo enhanced the beneficial effects of endogenous Cd39 boosted by the administration of the aryl-hydrocarbon-receptor (AhR) ligand unconjugated bilirubin (UCB). Bilirubin 173-182 aryl hydrocarbon receptor Homo sapiens 148-151 30508524-7 2019 On the other hand, numerous anti-inflammatory AHR agonists have been identified including bilirubin and quercetin. Bilirubin 90-99 aryl hydrocarbon receptor Homo sapiens 46-49 28547076-11 2017 As a recent example, upregulation of CD39 is dependent upon ligation of the aryl hydrocarbon receptor (AHR), as with natural ligands such as bilirubin and 2-(1" H-indole-3"-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE). Bilirubin 141-150 aryl hydrocarbon receptor Homo sapiens 76-101 28547076-11 2017 As a recent example, upregulation of CD39 is dependent upon ligation of the aryl hydrocarbon receptor (AHR), as with natural ligands such as bilirubin and 2-(1" H-indole-3"-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE). Bilirubin 141-150 aryl hydrocarbon receptor Homo sapiens 103-106 24837423-3 2014 The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1. Bilirubin 351-360 aryl hydrocarbon receptor Homo sapiens 161-164 24837423-3 2014 The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1. Bilirubin 351-360 aryl hydrocarbon receptor Homo sapiens 209-212 24837423-4 2014 In the latter case the AhR is one of multiple transcription factors contributing to bilirubin homeostasis. Bilirubin 84-93 aryl hydrocarbon receptor Homo sapiens 23-26 22820246-2 2012 For examples: (i) bilirubin is solely conjugated by UGT1A1 and activates its transcription factors Ah receptor, PXR and CAR. Bilirubin 18-27 aryl hydrocarbon receptor Homo sapiens 99-110