PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25750273-0	2015	The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines.	Silybin	14-23	phosphatase and tensin homolog	Homo sapiens	87-91	
30370304-5	2018	Treatment with SM or SB was found to significantly reduce the genotoxicity of MMS, upregulate the expression of PTEN and BCL2, and downregulate the expression of BAX and ABL1.	Silybin	21-23	phosphatase and tensin homolog	Homo sapiens	112-116	
28321778-6	2017	Compared to silibinin, miR-21 mimic transfection in combination with silibinin caused a slight modulation in some of the examined silibinin effects including apoptosis, Bcl2 mRNA and PTEN mRNA and protein levels.	Silybin	69-78	phosphatase and tensin homolog	Homo sapiens	183-187	
28321778-6	2017	Compared to silibinin, miR-21 mimic transfection in combination with silibinin caused a slight modulation in some of the examined silibinin effects including apoptosis, Bcl2 mRNA and PTEN mRNA and protein levels.	Silybin	69-78	phosphatase and tensin homolog	Homo sapiens	183-187	
27268647-4	2016	The effect of silibinin on PTEN, Bcl-2, P21, and P27 mRNAs expression was also investigated by real-time RT-PCR.	Silybin	14-23	phosphatase and tensin homolog	Homo sapiens	27-31	
27268647-7	2016	Silibinin upregulated PTEN in MCF-7 and caused slightly increased P21 mRNA expression in T47D cells and slightly increased PTEN and P21 expression in MCF-10A cells.	Silybin	0-9	phosphatase and tensin homolog	Homo sapiens	22-26	
27268647-7	2016	Silibinin upregulated PTEN in MCF-7 and caused slightly increased P21 mRNA expression in T47D cells and slightly increased PTEN and P21 expression in MCF-10A cells.	Silybin	0-9	phosphatase and tensin homolog	Homo sapiens	123-127	
25750273-4	2015	In this project, we evaluated the effects of silibinin, a natural plant component of milk thistle seeds, to potentiate toxic effects of chemotherapy drugs such as temozolomide, etoposide and irinotecan on LN229, U87 and A172 (P53 and phosphatase and tensin homolog (PTEN) -tumor suppressor-mutated) glioma cell lines.	Silybin	45-54	phosphatase and tensin homolog	Homo sapiens	266-270	
17879397-8	2007	We found that silibinin-reduced growth of HuH7 cells was associated with increased activity of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and decreased p-Akt production, indicating the role of PTEN/PI(3)K/Akt pathway in silibinin-mediated anti-HCC effects.	Silybin	14-23	phosphatase and tensin homolog	Homo sapiens	153-157	
17879397-8	2007	We found that silibinin-reduced growth of HuH7 cells was associated with increased activity of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and decreased p-Akt production, indicating the role of PTEN/PI(3)K/Akt pathway in silibinin-mediated anti-HCC effects.	Silybin	14-23	phosphatase and tensin homolog	Homo sapiens	214-218