PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26349994-0	2015	Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells.	Silybin	38-47	cyclin dependent kinase 1	Homo sapiens	123-127	
26349994-7	2015	Moreover, treatment with TSA and silibinin resulted in a profound reduction in the expression of cyclinA2, cyclinB1/Cdk1 and survivin.	Silybin	33-42	cyclin dependent kinase 1	Homo sapiens	116-120	
25169527-8	2014	Silibinin caused G2/M phage arrest accompanied by a decrease in CDK1 and Cyclin B1 at protein and mRNA levels..	Silybin	0-9	cyclin dependent kinase 1	Homo sapiens	64-68	
25169527-9	2014	CONCLUSIONS: These results suggest that silibinin inhibits the proliferation of MGC803 cells, and it induces apoptosis and causes cell cycle arrest by down-regulating CDK1, cyclinB1, survivin, Bcl-xl, Mcl-1 and activating caspase 3 and caspase 9, potentially via the STAT3 pathway.	Silybin	40-49	cyclin dependent kinase 1	Homo sapiens	167-171	
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Silybin	82-91	cyclin dependent kinase 1	Homo sapiens	132-136	
22619007-5	2013	In mechanistic studies, Silibinin decreased the protein level of p34cdc2, which might be the possible molecular mechanism of Silibinin efficacy on the growth inhibition in SGC-7901 cells.	Silybin	24-33	cyclin dependent kinase 1	Homo sapiens	65-72	
22619007-5	2013	In mechanistic studies, Silibinin decreased the protein level of p34cdc2, which might be the possible molecular mechanism of Silibinin efficacy on the growth inhibition in SGC-7901 cells.	Silybin	125-134	cyclin dependent kinase 1	Homo sapiens	65-72	
20554189-4	2010	Silibinin decreased the basal level of cyclin B1 and cdc2 expression, which is involved in S phase and G2/M transition.	Silybin	0-9	cyclin dependent kinase 1	Homo sapiens	53-57	
20554189-6	2010	Under the same conditions, TPA-induced down-regulation of cyclin B1 and cdc2 was decreased by silibinin.	Silybin	94-103	cyclin dependent kinase 1	Homo sapiens	72-76	
19147767-6	2009	Decreased levels of cyclin-dependent kinases 2, 4, and 6, CDC2, and cyclins D1, D3, E, and A were observed, indicating an inhibitory effect of silibinin on cell cycle progression.	Silybin	143-152	cyclin dependent kinase 1	Homo sapiens	58-62	
16205633-5	2006	The G2-M arrest by silibinin and silymarin was associated with decreased levels of cyclin B1, cyclin A, pCdc2 (Tyr15), Cdc2, and an inhibition of Cdc2 kinase activity.	Silybin	19-28	cyclin dependent kinase 1	Homo sapiens	105-109	
16205633-5	2006	The G2-M arrest by silibinin and silymarin was associated with decreased levels of cyclin B1, cyclin A, pCdc2 (Tyr15), Cdc2, and an inhibition of Cdc2 kinase activity.	Silybin	19-28	cyclin dependent kinase 1	Homo sapiens	119-123	
14614451-5	2003	In other studies, we observed that G2/M arrest by silibinin was associated with a decrease in cdc25C, cdc2/p34 and cyclin B1 protein levels, as well as cdc2/p34 kinase activity.	Silybin	50-59	cyclin dependent kinase 1	Homo sapiens	94-98	
14614451-5	2003	In other studies, we observed that G2/M arrest by silibinin was associated with a decrease in cdc25C, cdc2/p34 and cyclin B1 protein levels, as well as cdc2/p34 kinase activity.	Silybin	50-59	cyclin dependent kinase 1	Homo sapiens	102-106	
15117815-6	2004	In other studies, silibinin treatment strongly induced the expression of Cip1/p21 and Kip1/p27, but resulted in a decrease in cyclin-dependent kinases (CDKs) and cyclins involved in G(1) progression.	Silybin	18-27	cyclin dependent kinase 1	Homo sapiens	152-156	
15117815-7	2004	Silibinin treatment also showed an increased interaction between cyclin-dependent kinase inhibitors (CDKIs)-CDKs and a decreased CDK kinase activity.	Silybin	0-9	cyclin dependent kinase 1	Homo sapiens	108-112	
15117815-8	2004	Further, the G(2)/M arrest by silibinin in TCC-SUP cells was associated with a decrease in pCdc25c (Ser216), Cdc25c, pCdc2 (Tyr15), Cdc2 and cyclin B1 protein levels.	Silybin	30-39	cyclin dependent kinase 1	Homo sapiens	92-96