PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29050211-9 2017 Irradiating intestinal epithelial cells increased TGF-beta1 levels, but silibinin suppressed TGF-beta1 expression by inhibiting Smad2/3 phosphorylation. Silybin 72-81 SMAD family member 2 Mus musculus 128-135 34250649-9 2021 Moreover, SB harnessed the tissue architecture, improved diffusive scattering of x-ray signals, and modulated epithelial-mesenchymal phenotypic alterations, including TGF-beta, p-smad2/3, and collagen-I. Silybin 10-12 SMAD family member 2 Mus musculus 179-186 28602599-0 2017 Silibinin inhibits the fibrotic responses induced by cigarette smoke via suppression of TGF-beta1/Smad 2/3 signaling. Silybin 0-9 SMAD family member 2 Mus musculus 98-106 28602599-8 2017 Additionally, silibinin effectively inhibited CS + LPS-mediated expression of transforming growth factor-beta1 (TGF-beta1) and Smad 2/3 phosphorylation. Silybin 14-23 SMAD family member 2 Mus musculus 127-135 28602599-9 2017 Taken together, our data indicate that silibinin effectively inhibits the fibrotic response induced by CS + LPS exposure, possibly via suppression of TGF-beta1/Smad 2/3 signaling, which results in reduced collagen deposition. Silybin 39-48 SMAD family member 2 Mus musculus 160-168