PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30598040-6	2018	DHS diminished interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion but induced the significant upregulation of IL-8 mRNA associated with NF-kappaB and AP-1 activation.	Silybin	0-3	interleukin 6	Homo sapiens	15-28	
33822421-6	2021	Moreover, HUVECs pretreatment with silibinin reduced TNF-alpha-induced gene expression of the proinflammatory genes IL-6 and MCP-1, as well as of PAI-1, a critical factor in coagulopathy and thrombosis, and of ET-1, a peptide involved in hemostatic vasoconstriction.	Silybin	35-44	interleukin 6	Homo sapiens	116-120	
33045562-5	2020	The results showed that the in vitro treatment of monocytes from preeclamptic women with Sb downregulated the endogenous activation of NF-kappaB and the expression of surface receptors TLR4 and CD64, and reduced the synthesis of the pro-inflammatory cytokines interleukin 1 (IL-1beta), IL-6, IL-8, IL-12p70, IL-23, and tumour necrosis factor alpha (TNF-alpha) compared with cultures not treated with Sb.	Silybin	89-91	interleukin 6	Homo sapiens	286-290	
32164364-5	2020	In SiONPs-stimulated NCI-H292 airway epithelial cells, silibinin treatment effectively suppressed the elevation of the mRNA expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta, which was accompanied by the reduction in the expression of TXNIP, MAPKs, and activator protein-1 (AP-1).	Silybin	55-64	interleukin 6	Homo sapiens	179-197	
31631701-9	2019	The levels of inflammatory factors (TNF-alpha, IL-1beta, IL-6 and IL-10) were significantly regulated by silibinin treatment.	Silybin	105-114	interleukin 6	Homo sapiens	57-61	
31287731-5	2020	Results: Obesity increased the expression of proliferative signaling including COX-2, IL-6, AKT, ERK, and AR, which was attenuated with silibinin.	Silybin	136-145	interleukin 6	Homo sapiens	86-90	
30598040-6	2018	DHS diminished interleukin-6 (IL-6) and interleukin-8 (IL-8) secretion but induced the significant upregulation of IL-8 mRNA associated with NF-kappaB and AP-1 activation.	Silybin	0-3	interleukin 6	Homo sapiens	30-34	
17116726-6	2007	Silibinin also inhibited interleukin-6-induced ERK 1/2 and c-Jun phosphorylation, and cell invasiveness.	Silybin	0-9	interleukin 6	Homo sapiens	25-38	
24045679-8	2013	RESULTS: Silibinin suppressed the growth of HMC-1 cells and also reduced the production and mRNA expression of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-8.	Silybin	9-18	interleukin 6	Homo sapiens	157-161	
29660364-2	2018	Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705).	Silybin	0-9	interleukin 6	Homo sapiens	18-22	
24647589-7	2014	Fetal brains were collected after 6 h. In human fetal membranes, silibinin significantly decreased LPS-stimulated expression of IL-6 and IL-8, COX-2, and prostaglandins PGE2 and PGF2alpha.	Silybin	65-74	interleukin 6	Homo sapiens	128-132	
24647589-9	2014	Preterm fetal membranes with active infection treated with silibinin showed a decrease in IL-6, IL-8 and MMP-9 expression.	Silybin	59-68	interleukin 6	Homo sapiens	90-94	
23210512-0	2012	Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro.	Silybin	0-9	interleukin 6	Homo sapiens	35-39	
23210512-2	2012	This study investigated silibinin inhibition of cell invasion by down-regulating matrix metalloproteinase-2 (MMP-2) expression, via attenuation of activator protein-1 (AP-1) in IL-6-stimulated LoVo colon cancer cells.	Silybin	24-33	interleukin 6	Homo sapiens	177-181	
23210512-6	2012	Finally, a [(3)H]-thymidine incorporation proliferation assay and cell migration assay demonstrated that silibinin inhibited IL-6-stimulated LoVo cell proliferation and invasion.	Silybin	105-114	interleukin 6	Homo sapiens	125-129