PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23760395-0	2013	Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling.	Mefloquine	0-10	AKT serine/threonine kinase 1	Homo sapiens	94-97	
26780727-0	2016	Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway.	Mefloquine	0-10	AKT serine/threonine kinase 1	Homo sapiens	101-104	
26780727-6	2016	In addition, mefloquine potently decreased phosphorylation of PI3K, Akt, mTOR and rS6.	Mefloquine	13-23	AKT serine/threonine kinase 1	Homo sapiens	68-71	
26780727-7	2016	Overexpression of constitutively active Akt significantly restored mefloquine-mediated inhibition of mTOR phosphorylation and growth, and induction of apoptosis, suggesting that mefloquine acts on gastric cancer cells via suppressing PI3K/Akt/mTOR pathway.	Mefloquine	67-77	AKT serine/threonine kinase 1	Homo sapiens	40-43	
26780727-7	2016	Overexpression of constitutively active Akt significantly restored mefloquine-mediated inhibition of mTOR phosphorylation and growth, and induction of apoptosis, suggesting that mefloquine acts on gastric cancer cells via suppressing PI3K/Akt/mTOR pathway.	Mefloquine	67-77	AKT serine/threonine kinase 1	Homo sapiens	239-242	
26780727-7	2016	Overexpression of constitutively active Akt significantly restored mefloquine-mediated inhibition of mTOR phosphorylation and growth, and induction of apoptosis, suggesting that mefloquine acts on gastric cancer cells via suppressing PI3K/Akt/mTOR pathway.	Mefloquine	178-188	AKT serine/threonine kinase 1	Homo sapiens	40-43	
26780727-7	2016	Overexpression of constitutively active Akt significantly restored mefloquine-mediated inhibition of mTOR phosphorylation and growth, and induction of apoptosis, suggesting that mefloquine acts on gastric cancer cells via suppressing PI3K/Akt/mTOR pathway.	Mefloquine	178-188	AKT serine/threonine kinase 1	Homo sapiens	239-242	
26780727-8	2016	We further show that mefloquine-mediated inhibition of Akt/mTOR singaling is phosphatase-dependent as pretreatment with calyculin A does-dependently reversed mefloquine-mediated inhibition of Akt/mTOR phosphorylation.	Mefloquine	21-31	AKT serine/threonine kinase 1	Homo sapiens	55-58	
26780727-8	2016	We further show that mefloquine-mediated inhibition of Akt/mTOR singaling is phosphatase-dependent as pretreatment with calyculin A does-dependently reversed mefloquine-mediated inhibition of Akt/mTOR phosphorylation.	Mefloquine	21-31	AKT serine/threonine kinase 1	Homo sapiens	192-195	
26780727-8	2016	We further show that mefloquine-mediated inhibition of Akt/mTOR singaling is phosphatase-dependent as pretreatment with calyculin A does-dependently reversed mefloquine-mediated inhibition of Akt/mTOR phosphorylation.	Mefloquine	158-168	AKT serine/threonine kinase 1	Homo sapiens	55-58	
26780727-8	2016	We further show that mefloquine-mediated inhibition of Akt/mTOR singaling is phosphatase-dependent as pretreatment with calyculin A does-dependently reversed mefloquine-mediated inhibition of Akt/mTOR phosphorylation.	Mefloquine	158-168	AKT serine/threonine kinase 1	Homo sapiens	192-195	
23760395-11	2013	Moreover, we observed that MQ-mediated ROS simultaneously downregulated Akt phosphorylation and activated extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and adenosine monophosphate-activated protein kinase (AMPK) signaling in PC3 cells.	Mefloquine	27-29	AKT serine/threonine kinase 1	Homo sapiens	72-75