PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29923357-0	2018	The protective mechanism of Nigella sativa against diethylnitrosamine-induced hepatocellular carcinoma through its antioxidant effect and EGFR/ERK1/2 signaling.	Diethylnitrosamine	51-69	epidermal growth factor receptor	Rattus norvegicus	138-142	
2573415-10	1989	In general, effects on ER, epidermal growth factor receptor, gamma-glutamyl transpeptidase and glucose-6-phosphatase were greater in DEN/EE2-treated animals than in rats receiving only EE2.	Diethylnitrosamine	133-136	epidermal growth factor receptor	Rattus norvegicus	27-59	
33324209-8	2020	In a diethylnitrosamine (DEN)-induced rat model of HCC, we found that the expression of phosphorylated EGFR, PKM2 nuclear expression, H3-Thr11 phosphorylation as well as PD-L1 mRNA and protein was higher in the livers than that in normal rat livers.	Diethylnitrosamine	5-23	epidermal growth factor receptor	Rattus norvegicus	103-107	
33324209-8	2020	In a diethylnitrosamine (DEN)-induced rat model of HCC, we found that the expression of phosphorylated EGFR, PKM2 nuclear expression, H3-Thr11 phosphorylation as well as PD-L1 mRNA and protein was higher in the livers than that in normal rat livers.	Diethylnitrosamine	25-28	epidermal growth factor receptor	Rattus norvegicus	103-107	
29923357-7	2018	DENA administration activated EGFR/ERK1/2 signaling and caused a significant increase in P-EGFR and P-ERK1/2 as well as a significant up-regulation of expression of target genes such as PCNA, c-fos and Bcl2, which indicated the increase in cell proliferation.	Diethylnitrosamine	0-4	epidermal growth factor receptor	Rattus norvegicus	30-34	
29923357-7	2018	DENA administration activated EGFR/ERK1/2 signaling and caused a significant increase in P-EGFR and P-ERK1/2 as well as a significant up-regulation of expression of target genes such as PCNA, c-fos and Bcl2, which indicated the increase in cell proliferation.	Diethylnitrosamine	0-4	epidermal growth factor receptor	Rattus norvegicus	91-95	
29923357-11	2018	These data suggest that NSEE has a chemopreventive role in DENA-induced HCC through the inhibition of the EGFR/ERK1/2 signaling pathway and their target genes in addition to its role as an antioxidant.	Diethylnitrosamine	59-63	epidermal growth factor receptor	Rattus norvegicus	106-110	
15660382-10	2005	In conclusion, the blockade of EGFR activity by gefitinib has an antitumoral effect on the development of HCC in DEN-exposed rats, suggesting that it may provide benefit for the chemoprevention of HCC.	Diethylnitrosamine	113-116	epidermal growth factor receptor	Rattus norvegicus	31-35	
28216890-8	2017	RESULTS: Extensive DNA damage in acute study and a significant increase in levels of p-MAPKs", c-fos, c-jun, and EGFR was observed in N-diethylnitrosamine (200 mg/kg bw) and ferric nitrilotriacetate (9 mg/kg bw) alone treated rats.	Diethylnitrosamine	134-154	epidermal growth factor receptor	Rattus norvegicus	113-117	
17380077-16	2007	CONCLUSIONS: Increased expression of EGF-R and decreased expression of ErbB4, might be related with tumor progression during DEN-induced hepatocarcinogenesis.	Diethylnitrosamine	125-128	epidermal growth factor receptor	Rattus norvegicus	37-42	
2226252-0	1990	[Changes in the epidermal growth factor receptors in the liver cells of rats in N-nitrosodiethylamine-induced hepatic carcinogenesis].	Diethylnitrosamine	80-101	epidermal growth factor receptor	Rattus norvegicus	16-49	
2226252-1	1990	A sharp decrease in the number of epidermal growth factor receptors (EGF-R) in the rat liver plasma membranes had been found at different stages of diethylnitrosamine-induced carcinogenesis.	Diethylnitrosamine	148-166	epidermal growth factor receptor	Rattus norvegicus	34-67	
2226252-1	1990	A sharp decrease in the number of epidermal growth factor receptors (EGF-R) in the rat liver plasma membranes had been found at different stages of diethylnitrosamine-induced carcinogenesis.	Diethylnitrosamine	148-166	epidermal growth factor receptor	Rattus norvegicus	69-74