PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31070541-7 2018 RESULTS: The 20-week survival rate of DEN-induced liver cancer rats administered with oral 1,4-GL was increased from 45.0 to 70.0% with reduced carcinogenesis of the liver and significantly lowered serum alpha-fetoprotein level (14.28 +- 2.89 ng/mL vs. 18.56 +- 4.65 ng/mL, p = 0.012). Diethylnitrosamine 38-41 alpha-fetoprotein Rattus norvegicus 204-221 89903-5 1979 AFP became elevated after a number of weeks of exposure to diethylnitrosamine. Diethylnitrosamine 59-77 alpha-fetoprotein Rattus norvegicus 0-3 35437842-10 2022 DEN administration caused a significant increase in the levels of glutathione, superoxide dismutase, malondialdehyde, caspase-3, alpha-fetoprotein (AFP), AFPL3, glypican 3, and the expression of BAX. Diethylnitrosamine 0-3 alpha-fetoprotein Rattus norvegicus 129-146 35437842-10 2022 DEN administration caused a significant increase in the levels of glutathione, superoxide dismutase, malondialdehyde, caspase-3, alpha-fetoprotein (AFP), AFPL3, glypican 3, and the expression of BAX. Diethylnitrosamine 0-3 alpha-fetoprotein Rattus norvegicus 148-151 35453384-5 2022 Isatin ameliorated the deleterious effects of DENA/2-AAF on liver function as evidenced by reduced serum levels of AST, ALT, total bilirubin, albumin, and liver tumor biomarkers (CA19.9 and AFP) compared to control DENA/2-AAF-treated rats. Diethylnitrosamine 46-50 alpha-fetoprotein Rattus norvegicus 190-193 6209086-1 1984 The immunohistochemical localization of ligandin (L), A-protein (A) and alpha-fetoprotein (AFP) was studied in the liver of rats treated intraperitoneally with diethylnitrosamine (DENA). Diethylnitrosamine 160-178 alpha-fetoprotein Rattus norvegicus 91-94 34792748-9 2022 The levels of serum tumor markers, viz., alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA), elevated in rats induced with DEN, which then were reduced following Cucumis melo fruit treatment, indicating the anti-cancer activity of the drug. Diethylnitrosamine 131-134 alpha-fetoprotein Rattus norvegicus 41-58 34792748-9 2022 The levels of serum tumor markers, viz., alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA), elevated in rats induced with DEN, which then were reduced following Cucumis melo fruit treatment, indicating the anti-cancer activity of the drug. Diethylnitrosamine 131-134 alpha-fetoprotein Rattus norvegicus 60-63 32302048-5 2020 NDEA-alone-administered group II animals profoundly showed increased tumor incidence, reactive oxygen species, liver marker enzyme levels, serum bilirubin levels, tumor markers of carcinoembryonic antigen, alpha-fetoprotein, proliferative markers of argyrophilic nucleolar organizing regions, proliferating cell nuclear antigen (PCNA) expressions, phase I xenobiotic-metabolic enzymes and simultaneously decreased antioxidants, and phase II enzymes levels. Diethylnitrosamine 0-4 alpha-fetoprotein Rattus norvegicus 206-223 4130939-0 1973 Letter: Enhanced production of alpha-fetoprotein in hepatocarcinogenesis of rats prenatally exposed to diethylnitrosoamine. Diethylnitrosamine 103-122 alpha-fetoprotein Rattus norvegicus 31-48 33911466-7 2021 RESULTS: Cyan administration mitigated the effect of DEN/2-AFF induced PCL, decreased AFP levels, and improved liver function. Diethylnitrosamine 53-56 alpha-fetoprotein Rattus norvegicus 86-89 33193894-7 2020 Moreover, EJD effectively reduced the DEN-induced GST-Pi, AFP, CK19, c-Myc, and Ki67 protein expression in liver precancerous tissues. Diethylnitrosamine 38-41 alpha-fetoprotein Rattus norvegicus 58-61 28501584-6 2017 Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz., interlukin-6 (IL-6), Tumor necrosis factor (TNF-alpha) and Interleukin-1beta (IL-1beta) with decrease in body weight. Diethylnitrosamine 12-15 alpha-fetoprotein Rattus norvegicus 109-125 31665932-6 2022 The treatment of DEN/2AAF-administered rats with quercetin and naringenin significantly prevented the elevations in serum levels of liver function indicators (ALT, AST, ALP, gamma-GT, total bilirubin and albumin) and liver tumor biomarkers including AFP, CEA and CA19.9. Diethylnitrosamine 17-20 alpha-fetoprotein Rattus norvegicus 250-253 31450931-8 2019 Results: DENA induced elevation in liver function enzymeswith significant increase in oxidation and inflammation biomarkers and AFP while decreased levels of Nrf2 in liver,stomach and colon were detected. Diethylnitrosamine 9-13 alpha-fetoprotein Rattus norvegicus 128-131 29923357-8 2018 Furthermore, a significant elevation in alpha-fetoprotein (AFP) and hepatic enzymes was observed in DENA-treated rats in addition to a decrease in the antioxidant status. Diethylnitrosamine 100-104 alpha-fetoprotein Rattus norvegicus 40-57 29923357-8 2018 Furthermore, a significant elevation in alpha-fetoprotein (AFP) and hepatic enzymes was observed in DENA-treated rats in addition to a decrease in the antioxidant status. Diethylnitrosamine 100-104 alpha-fetoprotein Rattus norvegicus 59-62 28810822-5 2017 It was found that treatment of rats with diethylnitrosamine induced hepatic injury and caused significant increase in liver injury markers with a concomitant significant increase in both hepatic oxidative and inflammatory indices: alpha-fetoprotein, interferon gamma, and interleukin 6 in comparison with normal and irradiated beta-glucan-treated groups. Diethylnitrosamine 41-59 alpha-fetoprotein Rattus norvegicus 231-248 31663622-9 2020 Our results showed that tiopronin prevented the DENA-induced elevation of the liver function enzymes and AFP. Diethylnitrosamine 48-52 alpha-fetoprotein Rattus norvegicus 105-108 29204817-12 2018 Administration of combination therapy harmonized the DENA-induced elevation of serum biochemical parameters, including but not limited to, alpha-fetoprotein (AFP), alanine- and aspartate-aminotransferase, alkaline phosphatase, vascular endothelial growth factor (VEGF), and antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and lipid per oxidation (LPO). Diethylnitrosamine 53-57 alpha-fetoprotein Rattus norvegicus 139-156 29204817-12 2018 Administration of combination therapy harmonized the DENA-induced elevation of serum biochemical parameters, including but not limited to, alpha-fetoprotein (AFP), alanine- and aspartate-aminotransferase, alkaline phosphatase, vascular endothelial growth factor (VEGF), and antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and lipid per oxidation (LPO). Diethylnitrosamine 53-57 alpha-fetoprotein Rattus norvegicus 158-161 28501584-6 2017 Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz., interlukin-6 (IL-6), Tumor necrosis factor (TNF-alpha) and Interleukin-1beta (IL-1beta) with decrease in body weight. Diethylnitrosamine 12-15 alpha-fetoprotein Rattus norvegicus 127-130 24632418-2 2014 Hepatocellular carcinoma induced by DENA in male Wistar rats was manifested biochemically by significant elevation of serum alpha-feto protein (AFP) and carcinoembryonic antigen (CEA). Diethylnitrosamine 36-40 alpha-fetoprotein Rattus norvegicus 124-142 28123463-7 2017 Rats injected with DENA for eight weeks showed a high percentage of malignant changes in hepatic tissues, as well as a significant increases in the serum levels of AFP and AFU and significant reductions in the serum levels of IL-2 and IFN-gamma. Diethylnitrosamine 19-23 alpha-fetoprotein Rattus norvegicus 164-167 24632418-2 2014 Hepatocellular carcinoma induced by DENA in male Wistar rats was manifested biochemically by significant elevation of serum alpha-feto protein (AFP) and carcinoembryonic antigen (CEA). Diethylnitrosamine 36-40 alpha-fetoprotein Rattus norvegicus 144-147 17803529-10 2007 NDEA administration inhibited body weight, macro- and microscopically detectable liver tumors and increased levels of plasma AST, ALT and alpha-fetoprotein. Diethylnitrosamine 0-4 alpha-fetoprotein Rattus norvegicus 138-155 24026428-3 2013 Induction of hepatic cancer was confirmed after 7 days of DENA administration by measurement of elevated level of serum alpha-feto protein (AFP). Diethylnitrosamine 58-62 alpha-fetoprotein Rattus norvegicus 120-138 24026428-3 2013 Induction of hepatic cancer was confirmed after 7 days of DENA administration by measurement of elevated level of serum alpha-feto protein (AFP). Diethylnitrosamine 58-62 alpha-fetoprotein Rattus norvegicus 140-143 24026428-4 2013 Administration of DENA in a single dose lofted the levels of serum biochemical parameters like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total protein and AFP. Diethylnitrosamine 18-22 alpha-fetoprotein Rattus norvegicus 206-209 23609474-10 2013 RESULTS: Serum AFP, NO, TNF-alpha, and IL-6 levels and iNOS enzyme activity were significantly increased in rats treated with DENA. Diethylnitrosamine 126-130 alpha-fetoprotein Rattus norvegicus 15-18 22840450-9 2012 The levels of liver cancer markers such as AST, ALT, ALP, gamma-glutamyl transferase, TBL, AFP and carcinoembryonic antigen were substantially increased by NDEA treatment. Diethylnitrosamine 156-160 alpha-fetoprotein Rattus norvegicus 91-94 18629614-7 2008 DEN treatment resulted in increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5"-nucleotidase, bilirubin, alpha-fetoprotein, carcinoembryonic antigen, argyophillic nucleolar organizing regions, and proliferating cell nuclear antigen. Diethylnitrosamine 0-3 alpha-fetoprotein Rattus norvegicus 210-227 18339250-5 2008 NDEA augmented mesor and amplitude of rhythms in AST and ALT activity and plasma alpha-FP levels and mesor values of plasma TBARS, while decreasing mesor values of plasma GSH and erythrocyte SOD, CAT, GPx and GST. Diethylnitrosamine 0-4 alpha-fetoprotein Rattus norvegicus 81-89 11818250-8 2002 Plasma alpha-fetoprotein levels were markedly elevated in DEN-treated rats, while tumor necrosis factor-alpha levels were not. Diethylnitrosamine 58-61 alpha-fetoprotein Rattus norvegicus 7-24