PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28253265-3	2017	One impediment to the development of CA4 is an inherent conformational instability about the ethylene linker, which joins two aromatic rings.	ethylene	93-101	carbonic anhydrase 4	Homo sapiens	37-40	
28253265-4	2017	We have previously published preliminary data regarding structurally simplified biphenyl derivatives of CA4, lacking an ethylene linker, which retain anti-proliferative and pro-apoptotic activity, albeit at higher doses.	ethylene	120-128	carbonic anhydrase 4	Homo sapiens	104-107	
27156516-4	2017	One common strategy has been the incorporation of the ethylene linker into a ring system, thus preventing the isomerization of CA4 into the virtually inactive trans-isomer.	ethylene	54-62	carbonic anhydrase 4	Homo sapiens	127-130	
26845138-1	2016	Combretastatin A-4 (CA-4) is a natural product, which consists of two phenyl rings, linked by an ethylene bridge.	ethylene	97-105	carbonic anhydrase 4	Homo sapiens	20-24	
23564200-4	2013	Substitution of the ethylene bridge of CA-4 with the beta-lactam ring together with the aforementioned aryl substitutions improved the therapeutic efficacy of CA-4 up to 300-fold in the combretastatin refractory HT-29 cells.	ethylene	20-28	carbonic anhydrase 4	Homo sapiens	39-43	
23564200-4	2013	Substitution of the ethylene bridge of CA-4 with the beta-lactam ring together with the aforementioned aryl substitutions improved the therapeutic efficacy of CA-4 up to 300-fold in the combretastatin refractory HT-29 cells.	ethylene	20-28	carbonic anhydrase 4	Homo sapiens	159-163	
23232969-3	2013	However, the stilbenoid structure of CA-4, consisting of two phenyl rings linked by an ethylene bridge, renders the compound readily susceptible to isomerisation from its biologically active cis-conformation to its more thermodynamically stable but inactive trans-isomer.	ethylene	87-95	carbonic anhydrase 4	Homo sapiens	37-41