PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22618201-6 2012 The p38 inhibitor SB203580 and the STAT1 inhibitor EGCG blocked CM-induced IL-8 production at both early and late time periods. epigallocatechin gallate 51-55 signal transducer and activator of transcription 1 Homo sapiens 35-40 22020144-11 2012 We further demonstrated that EGCG inhibited Th1 and Th17 differentiation by downregulating their corresponding transcription factors (STAT1 and T-bet for Th1, and STAT3 and RORgammat for Th17). epigallocatechin gallate 29-33 signal transducer and activator of transcription 1 Homo sapiens 134-139 23741252-7 2012 Phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by IFN-gamma was also significantly inhibited by EGCG. epigallocatechin gallate 135-139 signal transducer and activator of transcription 1 Homo sapiens 19-69 23741252-7 2012 Phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by IFN-gamma was also significantly inhibited by EGCG. epigallocatechin gallate 135-139 signal transducer and activator of transcription 1 Homo sapiens 71-76 23741252-8 2012 Reporter assays indicated that EGCG inhibited the transcriptional activities of IDO promoters, IFN-stimulated response element and IFN-gamma activation sequence, activated by STAT1 phosphorylation. epigallocatechin gallate 31-35 signal transducer and activator of transcription 1 Homo sapiens 175-180 23741252-9 2012 These findings suggest that EGCG may exert antitumor effects on CRC, at least in part, by inhibiting the expression and function of IDO through the suppression of STAT1 activation. epigallocatechin gallate 28-32 signal transducer and activator of transcription 1 Homo sapiens 163-168 18678988-10 2008 Epigallocatechin gallate (EGCG), an inhibitor of STAT1-mediated signaling, and AG490, a Janus kinase (JAK) inhibitor, impaired P2X4-receptor mRNA up-regulation by IFN-gamma. epigallocatechin gallate 26-30 signal transducer and activator of transcription 1 Homo sapiens 49-54 20812906-4 2011 Among them, epigallocatechin-3-gallate (EGCG), the main polyphenol present in green tea leaves, efficiently protects heart from I/R injury and this action is strictly correlated to its anti-STAT1 property. epigallocatechin gallate 12-38 signal transducer and activator of transcription 1 Homo sapiens 190-195 20812906-4 2011 Among them, epigallocatechin-3-gallate (EGCG), the main polyphenol present in green tea leaves, efficiently protects heart from I/R injury and this action is strictly correlated to its anti-STAT1 property. epigallocatechin gallate 40-44 signal transducer and activator of transcription 1 Homo sapiens 190-195 19928918-0 2010 Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells. epigallocatechin gallate 75-105 signal transducer and activator of transcription 1 Homo sapiens 161-166 19928918-8 2010 The study results demonstrate that EGCG can inhibit translocation of STAT1 into nucleus in IFN-gamma-stimulated human oral cancer cells. epigallocatechin gallate 35-39 signal transducer and activator of transcription 1 Homo sapiens 69-74 19928918-9 2010 In addition, both tyrosine and serine phosphorylation of STAT1 are revealed to be suppressed by EGCG. epigallocatechin gallate 96-100 signal transducer and activator of transcription 1 Homo sapiens 57-62 19928918-10 2010 Moreover, phosphorylation of PKC-delta, JAK-1, and JAK-2, which are the upstream event for the activation of STAT1, are also inhibited by EGCG in IFN-gamma-stimulated human oral cancer cells. epigallocatechin gallate 138-142 signal transducer and activator of transcription 1 Homo sapiens 109-114 19928918-11 2010 These data show that EGCG inhibited IDO expression by blocking the IFN-gamma-induced JAK-PKC-delta-STAT1 signaling pathway. epigallocatechin gallate 21-25 signal transducer and activator of transcription 1 Homo sapiens 99-104 18784813-3 2008 We show HIV-1 Tat protein inhibits microglial uptake of Abeta1-42 peptide, a process that is enhanced by interferon-gamma (IFN-gamma) and rescued by the STAT1 inhibitor (-)-epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 169-199 signal transducer and activator of transcription 1 Homo sapiens 153-158 18784813-3 2008 We show HIV-1 Tat protein inhibits microglial uptake of Abeta1-42 peptide, a process that is enhanced by interferon-gamma (IFN-gamma) and rescued by the STAT1 inhibitor (-)-epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 201-205 signal transducer and activator of transcription 1 Homo sapiens 153-158 18850185-3 2007 Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). epigallocatechin gallate 123-127 signal transducer and activator of transcription 1 Homo sapiens 206-256 18850185-0 2007 Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid. epigallocatechin gallate 21-47 signal transducer and activator of transcription 1 Homo sapiens 103-108 18850185-3 2007 Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). epigallocatechin gallate 95-121 signal transducer and activator of transcription 1 Homo sapiens 206-256 18850185-3 2007 Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). epigallocatechin gallate 95-121 signal transducer and activator of transcription 1 Homo sapiens 258-263 18850185-3 2007 Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). epigallocatechin gallate 123-127 signal transducer and activator of transcription 1 Homo sapiens 258-263 15601580-11 2004 Recently, we reported that the polyphenolic agent epigallocatechin-3-gallate (EGCG), a major constituent of green tea and a potent inhibitor of STAT-1 activation, protects the myocardium against I/R injury. epigallocatechin gallate 78-82 signal transducer and activator of transcription 1 Homo sapiens 144-150 16174516-6 2005 Inhibition of signal transducer and activator transcription factor 1 (STAT1) with epigallocatechin-3-gallate (EGCG) prevented the inhibitory effect of IFN-gamma. epigallocatechin gallate 82-108 signal transducer and activator of transcription 1 Homo sapiens 14-68 16174516-6 2005 Inhibition of signal transducer and activator transcription factor 1 (STAT1) with epigallocatechin-3-gallate (EGCG) prevented the inhibitory effect of IFN-gamma. epigallocatechin gallate 82-108 signal transducer and activator of transcription 1 Homo sapiens 70-75 16174516-6 2005 Inhibition of signal transducer and activator transcription factor 1 (STAT1) with epigallocatechin-3-gallate (EGCG) prevented the inhibitory effect of IFN-gamma. epigallocatechin gallate 110-114 signal transducer and activator of transcription 1 Homo sapiens 14-68 15231486-8 2004 Thus, as a potential adjunct anti-inflammatory agent, EGCG can block STAT1-dependent events in gut epithelia and monocytes and prevent IFN-gamma-induced increased epithelial permeability. epigallocatechin gallate 54-58 signal transducer and activator of transcription 1 Homo sapiens 69-74 16174516-6 2005 Inhibition of signal transducer and activator transcription factor 1 (STAT1) with epigallocatechin-3-gallate (EGCG) prevented the inhibitory effect of IFN-gamma. epigallocatechin gallate 110-114 signal transducer and activator of transcription 1 Homo sapiens 70-75 16174516-7 2005 Treatment with IFN-gamma activated phospho-STAT1 was markedly attenuated by EGCG. epigallocatechin gallate 76-80 signal transducer and activator of transcription 1 Homo sapiens 43-48 15723092-7 2005 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate 77-103 signal transducer and activator of transcription 1 Homo sapiens 4-58 15723092-7 2005 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate 77-103 signal transducer and activator of transcription 1 Homo sapiens 60-65 15723092-7 2005 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate 105-109 signal transducer and activator of transcription 1 Homo sapiens 4-58 15723092-7 2005 The signal transducer and activator transcription factor 1 (STAT1) inhibitor epigallocatechin-3-gallate (EGCG) prevented inhibition of NHE activity by long- but not the short-term treatment with IFN-gamma. epigallocatechin gallate 105-109 signal transducer and activator of transcription 1 Homo sapiens 60-65 15723092-8 2005 Treatment with IFN-gamma activated phospho-p38 MAPK, this effect being detected as early as 1 h, persisting over 3 h and decreasing after 24 h. IFN-gamma produced a sustained action of phospho-STAT1 that was prevented by EGCG and partially attenuated by SB 203580 and insensitive to downregulation of PKC. epigallocatechin gallate 221-225 signal transducer and activator of transcription 1 Homo sapiens 193-198 15319365-5 2004 Moreover, EGCG reduced the expression of a known STAT-1 pro-apoptotic target gene, Fas receptor. epigallocatechin gallate 10-14 signal transducer and activator of transcription 1 Homo sapiens 49-55 15277314-8 2004 Inhibition of Raf-1, mitogen-activated protein kinase kinase (MAPKK/MEK), p38 MAPK and STAT1 with, respectively, GW 5074, PD 98059, SB 203580 and epigallocatechin gallate prevented inhibition of Na(+)-K(+)-ATPase activity by IFN-gamma. epigallocatechin gallate 146-170 signal transducer and activator of transcription 1 Homo sapiens 87-92 15277314-10 2004 Activation of phospho-STAT1 by IFN-gamma was almost abolished by epigallocatechin gallate and markedly reduced by SB 203580, but insensitive to downregulation of PKC. epigallocatechin gallate 65-89 signal transducer and activator of transcription 1 Homo sapiens 22-27 12485906-0 2002 Antiinflammatory action of EGCG, the main component of green tea, through STAT-1 inhibition. epigallocatechin gallate 27-31 signal transducer and activator of transcription 1 Homo sapiens 74-80 34649540-9 2021 Finally, genistein, daidzein, kaempferol, resveratrol, rosmarinic acid, triptolide, quercetin and (-)-epigallocatechin-3-gallate were selected from the TCMSP database, and both of them is the STAT-1 inhibitor. epigallocatechin gallate 98-128 signal transducer and activator of transcription 1 Homo sapiens 192-198 34832863-0 2021 EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses. epigallocatechin gallate 0-4 signal transducer and activator of transcription 1 Homo sapiens 56-60 34832863-4 2021 In vitro experiments revealed that EGCG treatment inhibited interferon-gamma (IFN-gamma)-induced PD-L1 and PD-L2 expression and JAK-STAT signaling. epigallocatechin gallate 35-39 signal transducer and activator of transcription 1 Homo sapiens 132-136 34832863-8 2021 Dissimilar to anti-PD-1 treatment that blocks PD-1/PD-L1 interaction, EGCG inhibited JAK/STAT signaling and PD-L1 expression in tumor cells, leading to the re-activation of T cells. epigallocatechin gallate 70-74 signal transducer and activator of transcription 1 Homo sapiens 89-93 34832863-9 2021 In summary, we demonstrate that EGCG enhances anti-tumor immune responses by inhibiting JAK-STAT signaling in melanoma. epigallocatechin gallate 32-36 signal transducer and activator of transcription 1 Homo sapiens 92-96 11344123-0 2001 Anti-interferon gamma action of epigallocatechin-3-gallate mediated by specific inhibition of STAT1 activation. epigallocatechin gallate 32-58 signal transducer and activator of transcription 1 Homo sapiens 94-99 34649540-10 2021 The results of reverse molecular docking suggest that in addition to triptolide, (-)-Epigallocatechin-3-gallate and resveratrol, the other 5 compounds (flavonoids) with similar structures may bind to the same position of STAT1 protein with different docking score. epigallocatechin gallate 81-111 signal transducer and activator of transcription 1 Homo sapiens 221-226 32708322-4 2020 Indeed, many studies registered that EGCG inhibits signal transducer and activator of transcription (STAT)1/3 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) transcription factors, whose activities are crucial in a multiplicity of downstream pro-inflammatory signaling pathways. epigallocatechin gallate 37-41 signal transducer and activator of transcription 1 Homo sapiens 51-109 30558329-0 2018 Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients. epigallocatechin gallate 0-26 signal transducer and activator of transcription 1 Homo sapiens 36-42 30558329-5 2018 In vitro treatment of HaCat and Jurkat cells with 40 mum EGCG for 48 h was performed to measure the level of phosphorylation of signal transducer and activator of transcription protein STAT1, and replicated in ex vivo model using PBMCs of AA patients. epigallocatechin gallate 57-61 signal transducer and activator of transcription 1 Homo sapiens 185-190 30558329-6 2018 RESULTS: Interestingly, 40 mum EGCG is capable of completely inhibiting phosphorylation of STAT1 after 48 h in HaCat and Jurkat cells and ex vivo in PBMCs of AA patients. epigallocatechin gallate 31-35 signal transducer and activator of transcription 1 Homo sapiens 91-96 30558329-7 2018 Based on QPCR data, the action of EGCG on p-STAT1 seems to be mediated via downregulation of the expression of JAK2 but not JAK1 leading to the inhibition of human leukocyte antigens (HLA-DR and HLA-B) expression probably via IRF-1. epigallocatechin gallate 34-38 signal transducer and activator of transcription 1 Homo sapiens 44-49 28703809-8 2017 In vitro studies showed that EGCG reduced cisplatin-induced ROS generation and ERK1/2 and signal transducer and activator of transcription-1 (STAT1) activity, but preserved the activity of STAT3 and Bcl-xL. epigallocatechin gallate 29-33 signal transducer and activator of transcription 1 Homo sapiens 90-140 30126206-4 2018 The mRNA and protein levels of IFN-gamma-induced PD-L1 were reduced 40-80% after pretreatment with EGCG and green tea extract (GTE) in A549 cells, via inhibition of JAK2/STAT1 signaling. epigallocatechin gallate 99-103 signal transducer and activator of transcription 1 Homo sapiens 170-175 28703809-8 2017 In vitro studies showed that EGCG reduced cisplatin-induced ROS generation and ERK1/2 and signal transducer and activator of transcription-1 (STAT1) activity, but preserved the activity of STAT3 and Bcl-xL. epigallocatechin gallate 29-33 signal transducer and activator of transcription 1 Homo sapiens 142-147 25261409-0 2014 Epigallocatechin-3-gallate sensitizes IFN-gamma-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1. epigallocatechin gallate 0-26 signal transducer and activator of transcription 1 Homo sapiens 115-120 26345342-5 2015 In primary cultured human melanocytes, EGCG pre-treatment attenuated interferon (IFN)-gamma-induced phosphorylation of JAK2 and its downstream signal transducer and activator of transcription (STAT)1 and STAT3 in a dose-dependent manner. epigallocatechin gallate 39-43 signal transducer and activator of transcription 1 Homo sapiens 143-199 25261409-7 2014 The increases in STAT1 activation and apoptosis induced by EGCG in IFN-gamma-activated CD4(+) T cells were almost completely abolished by a selective Src family kinase inhibitor, SU6656. epigallocatechin gallate 59-63 signal transducer and activator of transcription 1 Homo sapiens 17-22 25261409-9 2014 In conclusion, the present study reports an alternative activation of STAT1 via Src by EGCG in IFN-gamma-activated CD4(+) T cells, which promotes the apoptosis of IFN-gamma-activated CD4(+) T cells and contributes to the improvement of T cell-mediated colitis. epigallocatechin gallate 87-91 signal transducer and activator of transcription 1 Homo sapiens 70-75 23676554-2 2014 The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD. epigallocatechin gallate 63-67 signal transducer and activator of transcription 1 Homo sapiens 182-187 24038588-3 2014 The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin-6 and interferon-gamma in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated-STAT1 and STAT3 proteins in a dose-dependent manner. epigallocatechin gallate 182-186 signal transducer and activator of transcription 1 Homo sapiens 243-248 24255956-1 2014 Our previous studies showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits signal transducer activator of transcription 1 (STAT1) activation. epigallocatechin gallate 33-63 signal transducer and activator of transcription 1 Homo sapiens 80-126 24255956-1 2014 Our previous studies showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits signal transducer activator of transcription 1 (STAT1) activation. epigallocatechin gallate 33-63 signal transducer and activator of transcription 1 Homo sapiens 128-133 24255956-1 2014 Our previous studies showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits signal transducer activator of transcription 1 (STAT1) activation. epigallocatechin gallate 65-69 signal transducer and activator of transcription 1 Homo sapiens 80-126 24255956-1 2014 Our previous studies showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits signal transducer activator of transcription 1 (STAT1) activation. epigallocatechin gallate 65-69 signal transducer and activator of transcription 1 Homo sapiens 128-133 23676554-2 2014 The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD. epigallocatechin gallate 35-61 signal transducer and activator of transcription 1 Homo sapiens 130-180 23676554-2 2014 The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD. epigallocatechin gallate 35-61 signal transducer and activator of transcription 1 Homo sapiens 182-187 23676554-2 2014 The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD. epigallocatechin gallate 63-67 signal transducer and activator of transcription 1 Homo sapiens 130-180 24728078-3 2014 The STAT1 inhibitor EGCG was a more effective inhibitor of the endocrine resistant MCF-7/LCC1 and MCF-7/LCC9 lines than parental MCF-7 cells, while STAT3 inhibitors Stattic and WP1066 were equally effective in endocrine-resistant and parental lines. epigallocatechin gallate 20-24 signal transducer and activator of transcription 1 Homo sapiens 4-9 23158905-3 2013 On the basis of the flavane nature of the isolated compounds and considering the strong anti-STAT1 activity reported for epigallocatechin 3-O-gallate (EGCG), the affinity of compounds 1-3 for STAT1 has been evaluated by Surface Plasmon Resonance. epigallocatechin gallate 151-155 signal transducer and activator of transcription 1 Homo sapiens 93-98 23158905-3 2013 On the basis of the flavane nature of the isolated compounds and considering the strong anti-STAT1 activity reported for epigallocatechin 3-O-gallate (EGCG), the affinity of compounds 1-3 for STAT1 has been evaluated by Surface Plasmon Resonance. epigallocatechin gallate 151-155 signal transducer and activator of transcription 1 Homo sapiens 192-197