PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26957211-0 2016 Epigallocatechin-3-gallate ameliorates autoimmune arthritis by reciprocal regulation of T helper-17 regulatory T cells and inhibition of osteoclastogenesis by inhibiting STAT3 signaling. epigallocatechin gallate 0-26 signal transducer and activator of transcription 3 Mus musculus 170-175 28967875-0 2017 Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway. epigallocatechin gallate 25-55 signal transducer and activator of transcription 3 Mus musculus 131-136 28967875-9 2017 Here, we found that curcumin combination with EGCG attenuated the tumor CM-induced transition of NECs toward TECs by inhibiting JAK/STAT3 signaling pathway. epigallocatechin gallate 46-50 signal transducer and activator of transcription 3 Mus musculus 132-137 26957211-7 2016 The expression of cytokines, oxidative stress proteins, and phosphorylated-signal transducer and activator of transcription-3, 705 and 727, were significantly less in mice treated with epigallocatechin-3-gallate than it was in controls. epigallocatechin gallate 185-211 signal transducer and activator of transcription 3 Mus musculus 75-125 26957211-12 2016 At the molecular level, the antiarthritic effects of epigallocatechin-3-gallate may be due to induction of phosphorylated-extracellular signal-regulated kinase, nuclear respiratory factor 2, and heme oxygenase-1 and inhibition of signal transducer and activator of transcription-3 activation. epigallocatechin gallate 53-79 signal transducer and activator of transcription 3 Mus musculus 230-280 21372039-6 2011 EGCG inhibited the phosphorylation of the IGF-1R, ERK (extracellular signal-regulated kinase), Akt, GSK-3beta (glycogen synthase kinase-3beta), Stat3, and JNK (c-Jun NH(2)-terminal kinase) proteins in the livers of experimental mice. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 144-149 26929598-7 2016 EGCG also exhibited an antiapoptotic and antiautophagic effect by inhibiting BNIP3 via the IL-6/JAKs/STAT3 pathway. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 101-106 26929598-8 2016 CONCLUSION: EGCG attenuated liver injury in ConA-induced hepatitis by downregulating IL-6/JAKs/STAT3/BNIP3-mediated apoptosis and autophagy. epigallocatechin gallate 12-16 signal transducer and activator of transcription 3 Mus musculus 95-100 26668622-8 2015 EGCG could reduce the release of IL-6 and IL-17 and regulate the mouse splenic regulatory T-cell (Treg)/T helper 17 cell (Th17) ratio, while increasing the plasma levels of IL-10 and TGF-beta1 and decreasing the HIF-1alpha and STAT3 protein expression in the colon. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 227-232 24558360-0 2014 EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 54-59 24558360-5 2014 The expression of pro-inflammatory cytokines, oxidative stress proteins, and p-STAT3 (Y705) and p-STAT3 (S727), mTOR and HIF-1alpha were significantly lower in mice treated with EGCG. epigallocatechin gallate 178-182 signal transducer and activator of transcription 3 Mus musculus 79-84 24558360-5 2014 The expression of pro-inflammatory cytokines, oxidative stress proteins, and p-STAT3 (Y705) and p-STAT3 (S727), mTOR and HIF-1alpha were significantly lower in mice treated with EGCG. epigallocatechin gallate 178-182 signal transducer and activator of transcription 3 Mus musculus 98-103 24558360-8 2014 In vitro, p-STAT3 (Y705) and p-STAT3 (S727), HIF1alpha and glycolytic pathway molecules were decreased by EGCG. epigallocatechin gallate 106-110 signal transducer and activator of transcription 3 Mus musculus 12-17 24558360-8 2014 In vitro, p-STAT3 (Y705) and p-STAT3 (S727), HIF1alpha and glycolytic pathway molecules were decreased by EGCG. epigallocatechin gallate 106-110 signal transducer and activator of transcription 3 Mus musculus 31-36 24239847-6 2014 EGCG also induced a higher Treg/Th17 cell ratio in CD4(+) T-cell differentiation by decreasing the ratio of STAT3/STAT5 expression in DIO mice. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 108-113 24239847-9 2014 Thus, EGCG has an anti-inflammatory effect by suppressing STAT3 proteins and Th17-cell differentiation. epigallocatechin gallate 6-10 signal transducer and activator of transcription 3 Mus musculus 58-63 24239847-10 2014 EGCG thus shows promise for treating autoimmune conditions related to STAT3 or Th17 cells, such as metabolic syndrome, inflammatory arthritis, and some neoplastic diseases. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 70-75 23064699-5 2013 These effects, in turn, may be mediated by EGCG-induced downregulation of transducers p-STAT1 and p-STAT4 for Th1, and p-STAT3 for Th17. epigallocatechin gallate 43-47 signal transducer and activator of transcription 3 Mus musculus 121-126 23064699-6 2013 EGCG-induced change in Th17/Treg balance may be mediated by its inhibition of IL-6 signaling because EGCG inhibited soluble IL-6R, membrane gp130, and IL-6-induced phosphorylation of STAT3. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 183-188 23064699-6 2013 EGCG-induced change in Th17/Treg balance may be mediated by its inhibition of IL-6 signaling because EGCG inhibited soluble IL-6R, membrane gp130, and IL-6-induced phosphorylation of STAT3. epigallocatechin gallate 101-105 signal transducer and activator of transcription 3 Mus musculus 183-188 22819551-6 2013 In addition, EGCG also attenuated TNF-alpha-induced oxidative stress, p47(phox) translocation, MAPKs activation, and STAT-3 and activating transcription factor (ATF)2 phosphorylation. epigallocatechin gallate 13-17 signal transducer and activator of transcription 3 Mus musculus 117-123 31614951-5 2019 In conclusion, EGCG can attenuate high-fat-induced hypothalamic inflammation via inhibiting the JAK2/STAT3 signaling pathways in microglia. epigallocatechin gallate 15-19 signal transducer and activator of transcription 3 Mus musculus 101-106 17348027-4 2007 At a concentration of 20 microM, EGCG decreased the migratory potential of bladder carcinoma cells with concomitant activation of p42/44 MAPK and STAT3 and inactivation of Akt. epigallocatechin gallate 33-37 signal transducer and activator of transcription 3 Mus musculus 146-151 34564613-0 2021 Effect of (-)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A. Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130. epigallocatechin gallate 10-38 signal transducer and activator of transcription 3 Mus musculus 60-64 34564613-6 2021 Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3. epigallocatechin gallate 75-79 signal transducer and activator of transcription 3 Mus musculus 151-156 34564613-7 2021 It was thought that the hydroxyl group at position 3 of the galloyl group in the EGCG was responsible for binding to SEA and suppressing SEA-induced phosphorylation of STAT3. epigallocatechin gallate 81-85 signal transducer and activator of transcription 3 Mus musculus 168-173 34564613-8 2021 Through protein thermal shift assay in vitro, the binding of the gp130 receptor to SEA and the phosphorylation of STAT3 were inhibited by the interaction between EGCG and SEA. epigallocatechin gallate 162-166 signal transducer and activator of transcription 3 Mus musculus 114-119 34564613-9 2021 As far as we know, this is the first report to document that EGCG inhibits the binding of the gp130 receptor to SEA and the associated phosphorylation of STAT3. epigallocatechin gallate 61-65 signal transducer and activator of transcription 3 Mus musculus 154-159 34269008-4 2021 Results indicated that EGCG and metformin exhibited a synergistic effect on cell viability, migration, and proliferation, as well as signal transducer and activator of transcription 3/nuclear factor-kappaB (STAT3/NF-kappaB) pathway signaling and the production of inflammation cytokines. epigallocatechin gallate 23-27 signal transducer and activator of transcription 3 Mus musculus 207-212 32290071-6 2020 EGCG down-regulated the canonical pathways in MDSCs, mainly through the Arg-1/iNOS/Nox2/NF-kappaB/STAT3 signaling pathway. epigallocatechin gallate 0-4 signal transducer and activator of transcription 3 Mus musculus 98-103 19145512-12 2009 Stat3 activation was dose-dependently suppressed by EGCG in tumor cells, and an average of 53.5% reduction was observed in tumor tissues, but EGCG treatment did not change total Stat3 expression. epigallocatechin gallate 52-56 signal transducer and activator of transcription 3 Mus musculus 0-5 19145512-12 2009 Stat3 activation was dose-dependently suppressed by EGCG in tumor cells, and an average of 53.5% reduction was observed in tumor tissues, but EGCG treatment did not change total Stat3 expression. epigallocatechin gallate 142-146 signal transducer and activator of transcription 3 Mus musculus 0-5 19145512-13 2009 CONCLUSION: EGCG reduces expression of VEGF in gastric cancer by inhibiting activation of Stat3, thereby inhibits tumor growth and angiogenesis of gastric cancer. epigallocatechin gallate 12-16 signal transducer and activator of transcription 3 Mus musculus 90-95 34227806-0 2021 Promotion Effect of EGCG on the Raised Expression of IL-23 through the Signaling of STAT3-BATF2-c-JUN/ATF2. epigallocatechin gallate 20-24 signal transducer and activator of transcription 3 Mus musculus 84-89 34227806-11 2021 The results indicated that EGCG inhibits the phosphorylation of STAT3 to facilitate the decreased level of BATF2, which contributed to the increased level of IL-23 by the enhancing heterodimerization of c-JUN and ATF2. epigallocatechin gallate 27-31 signal transducer and activator of transcription 3 Mus musculus 64-69 32545266-0 2020 Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression. epigallocatechin gallate 0-26 signal transducer and activator of transcription 3 Mus musculus 59-64 32545266-0 2020 Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression. epigallocatechin gallate 28-32 signal transducer and activator of transcription 3 Mus musculus 59-64 30400620-7 2018 Experimental results demonstrated that dietary supplementation of EGCG significantly inhibited HFD-induced obesity by enhancing BAT thermogenesis, and attenuated the hypothalamic inflammation and microglia overactivation by regulating the NF-kappaB and STAT3 signaling pathways. epigallocatechin gallate 66-70 signal transducer and activator of transcription 3 Mus musculus 253-258