PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32770567-0 2021 Epigallocatechin gallate and theaflavin gallate interaction in SARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study. epigallocatechin gallate 0-24 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 74-79 32770567-7 2021 Moreover, out of three distinct binding sites (I, II and III) of spike core when HCQ binds only with site III (farthest from the nCoV-RBD of ACE2 contact), epigallocatechin gallate and theaflavin gallate bind all three sites. epigallocatechin gallate 156-180 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 65-70 32770567-6 2021 In the current study we demonstrated by bioinformatics (CASTp: computed atlas of surface topography of protein, PyMol: molecular visualization) and molecular docking (PatchDock and Autodock) experiments that tea flavonoids catechin products mainly epigallocatechin gallate or other like theaflavin gallate demonstrated higher atomic contact energy (ACE) value, binding energy, Ki value, ligand efficiency, surface area and more amino acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike protein. epigallocatechin gallate 248-272 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 527-532 34461999-0 2021 Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. epigallocatechin gallate 0-24 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 114-119 33425427-7 2020 The results showed that hesperidin, nabiximols, pectolinarin, epigallocatechin gallate, and rhoifolin had better poses than nelfinavir, chloroquine, and hydroxychloroquine sulfate as spike glycoprotein inhibitors. epigallocatechin gallate 62-86 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 183-188 33149560-8 2020 However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78. epigallocatechin gallate 31-55 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 137-142 33149560-8 2020 However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78. epigallocatechin gallate 57-61 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 137-142 34243689-8 2021 Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid. epigallocatechin gallate 125-129 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 49-54 34243689-11 2021 SAR analysis revealed that isomeldenin, tinosporaside, EGCG and ellagic acid bind to viral spike glycoproteins via H-bond, Pi-Pi, Pi-sigma and Pi-alkyl type interactions. epigallocatechin gallate 55-59 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 91-96 35382132-8 2022 Conclusion: EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly Mpro protein and spike glycoprotein of SARS-CoV-2. epigallocatechin gallate 12-16 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 145-150 35475273-8 2022 Conclusion: EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly Mpro protein and spike glycoprotein of SARS-CoV-2. epigallocatechin gallate 12-16 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 145-150