PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29446867-0 2018 Epigallocatechin Gallate Reduces Amyloid beta-Induced Neurotoxicity via Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis. epigallocatechin gallate 0-24 amyloid beta precursor protein Homo sapiens 33-45 29658548-4 2018 Here, we discuss recent advancements in solution NMR that have been instrumental in overcoming these limitations and we provide two representative examples of Abeta inhibitors from our work to demonstrate the applications of such experiments, i.e. EGCG and human serum albumin. epigallocatechin gallate 248-252 amyloid beta precursor protein Homo sapiens 159-164 29031698-5 2017 The multiple-ring compounds, EGCG, resveratrol, and curcumin, redirect Abeta(17-36) from a fibrillar aggregate to an unstructured oligomer. epigallocatechin gallate 29-33 amyloid beta precursor protein Homo sapiens 71-76 29031698-8 2017 The rank order of inhibitory effectiveness of Abeta(17-36) aggregation is as follows: EGCG > resveratrol > curcumin > vanillin, consistent with experimental findings on inhibiting full-length Abeta fibrillation. epigallocatechin gallate 86-90 amyloid beta precursor protein Homo sapiens 46-51 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 0-28 amyloid beta precursor protein Homo sapiens 100-120 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 0-28 amyloid beta precursor protein Homo sapiens 122-127 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 0-28 amyloid beta precursor protein Homo sapiens 161-166 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 0-28 amyloid beta precursor protein Homo sapiens 161-166 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 30-34 amyloid beta precursor protein Homo sapiens 100-120 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 30-34 amyloid beta precursor protein Homo sapiens 122-127 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 30-34 amyloid beta precursor protein Homo sapiens 161-166 28841302-1 2017 (-)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer"s disease beta-amyloid peptide (Abeta) by remodeling seeding-competent Abeta oligomers into off-pathway seeding-incompetent Abeta assemblies. epigallocatechin gallate 30-34 amyloid beta precursor protein Homo sapiens 161-166 28841302-3 2017 Here we combine 15N and 1H dark-state exchange saturation transfer (DEST), relaxation, and chemical shift projection NMR analyses with fluorescence, dynamic light scattering, and electron microscopy to elucidate how EGCG remodels Abeta oligomers. epigallocatechin gallate 216-220 amyloid beta precursor protein Homo sapiens 230-235 28841302-4 2017 We show that the remodeling adheres to a Hill-Scatchard model whereby the Abeta(1-40) self-association occurs cooperatively and generates Abeta(1-40) oligomers with multiple independent binding sites for EGCG with a Kd ~10-fold lower than that for the Abeta(1-40) monomers. epigallocatechin gallate 204-208 amyloid beta precursor protein Homo sapiens 74-79 28841302-4 2017 We show that the remodeling adheres to a Hill-Scatchard model whereby the Abeta(1-40) self-association occurs cooperatively and generates Abeta(1-40) oligomers with multiple independent binding sites for EGCG with a Kd ~10-fold lower than that for the Abeta(1-40) monomers. epigallocatechin gallate 204-208 amyloid beta precursor protein Homo sapiens 138-143 28841302-4 2017 We show that the remodeling adheres to a Hill-Scatchard model whereby the Abeta(1-40) self-association occurs cooperatively and generates Abeta(1-40) oligomers with multiple independent binding sites for EGCG with a Kd ~10-fold lower than that for the Abeta(1-40) monomers. epigallocatechin gallate 204-208 amyloid beta precursor protein Homo sapiens 138-143 28841302-5 2017 Upon binding to EGCG, the Abeta(1-40) oligomers become less solvent exposed, and the beta-regions, which are involved in direct monomer-protofibril contacts in the absence of EGCG, undergo a direct-to-tethered contact shift. epigallocatechin gallate 16-20 amyloid beta precursor protein Homo sapiens 26-31 28841302-6 2017 This switch toward less engaged monomer-protofibril contacts explains the seeding incompetency observed upon EGCG remodeling and suggests that EGCG interferes with secondary nucleation events known to generate toxic Abeta assemblies. epigallocatechin gallate 143-147 amyloid beta precursor protein Homo sapiens 216-221 28841302-7 2017 Unexpectedly, the N-terminal residues experience an opposite EGCG-induced shift from tethered to direct contacts, explaining why EGCG remodeling occurs without release of Abeta(1-40) monomers. epigallocatechin gallate 61-65 amyloid beta precursor protein Homo sapiens 171-176 28841302-8 2017 We also show that upon binding Abeta(1-40) oligomers the relative positions of the EGCG B and D rings change with respect to that of ring A. epigallocatechin gallate 83-87 amyloid beta precursor protein Homo sapiens 31-36 28841302-9 2017 These distinct structural changes occurring in both Abeta(1-40) oligomers and EGCG during remodeling offer a foundation for understanding the molecular mechanism of EGCG as a neurotoxicity inhibitor. epigallocatechin gallate 165-169 amyloid beta precursor protein Homo sapiens 52-57 28049055-9 2017 Kinetic studies with Abeta40 revealed that the two inhibitors functioned in different Abeta assembling stages: NP10 mainly inhibited primary nucleation, while EGCG suppressed fibril elongation and changed the fibril structure to make it show less seeding activities in the secondary nucleation. epigallocatechin gallate 159-163 amyloid beta precursor protein Homo sapiens 21-26 27507654-3 2017 However, previous studies indicated that as histone deacetylase inhibitors, both (-)-epigallocatechin-3-gallate and valproic acid presented the effects of downregulation of amyloid precursor protein expression, which resulted in the induction of apoptosis. epigallocatechin gallate 81-111 amyloid beta precursor protein Homo sapiens 173-198 28658644-3 2017 It has been found that EGCG prevents the formation of Abeta oligomer through two different ways by either accelerating the Abeta oligomerization or reducing the beta-content of the hexamer. epigallocatechin gallate 23-27 amyloid beta precursor protein Homo sapiens 54-59 28658644-3 2017 It has been found that EGCG prevents the formation of Abeta oligomer through two different ways by either accelerating the Abeta oligomerization or reducing the beta-content of the hexamer. epigallocatechin gallate 23-27 amyloid beta precursor protein Homo sapiens 123-128 28658644-7 2017 As a result, the binding free energy of the EGCG to the Abeta peptides is slightly larger than that of the curcumin. epigallocatechin gallate 44-48 amyloid beta precursor protein Homo sapiens 56-61 28049055-10 2017 NP10 might also help EGCG binding to Abeta, leading to its enhanced inhibitory effects on fibril elongation and secondary nucleation. epigallocatechin gallate 21-25 amyloid beta precursor protein Homo sapiens 37-42 24131107-5 2013 Here, ion mobility methods are utilized to deduce the modulation of peptide self-assembly pathways in the amyloid-beta protein fragment Abeta(25-35) by two amyloid inhibitors (epigallocatechin gallate and scyllo-inositol) that are currently in clinical trials for Alzheimer"s Disease. epigallocatechin gallate 176-200 amyloid beta precursor protein Homo sapiens 136-141 24195102-3 2014 In this report, the interaction of amyloid-beta (Abeta) with well-described modulators, (-)epigallocatechin-3-gallate (EGCG) and Zn(ii), was detected using a LED-based interferometric reflectance imaging sensor (LED-IRIS) in a high-throughput and real-time format. epigallocatechin gallate 88-117 amyloid beta precursor protein Homo sapiens 49-54 24195102-3 2014 In this report, the interaction of amyloid-beta (Abeta) with well-described modulators, (-)epigallocatechin-3-gallate (EGCG) and Zn(ii), was detected using a LED-based interferometric reflectance imaging sensor (LED-IRIS) in a high-throughput and real-time format. epigallocatechin gallate 119-123 amyloid beta precursor protein Homo sapiens 49-54 24195102-4 2014 Nucleation-based fibril growth strategy was employed, as the "seeds" of Abeta were prepared in the presence of EGCG and Zn(ii). epigallocatechin gallate 111-115 amyloid beta precursor protein Homo sapiens 72-77 22860214-13 2012 Exploration of the binding of EGCG and CLR01 to Abeta using heteronuclear solution-state NMR showed that whereas CLR01 bound to the two Lys and single Arg residues in Abeta monomers, only weak, nonspecific binding was detected for EGCG, leaving the binding mode of the latter unresolved. epigallocatechin gallate 30-34 amyloid beta precursor protein Homo sapiens 48-53 23537203-2 2013 The polyphenol (-)-epigallocatechin gallate (EGCG) was recently reported to inhibit Abeta fibrillization and redirect Abeta aggregation into unstructured, off-pathway oligomers. epigallocatechin gallate 15-43 amyloid beta precursor protein Homo sapiens 84-89 23537203-2 2013 The polyphenol (-)-epigallocatechin gallate (EGCG) was recently reported to inhibit Abeta fibrillization and redirect Abeta aggregation into unstructured, off-pathway oligomers. epigallocatechin gallate 15-43 amyloid beta precursor protein Homo sapiens 118-123 23537203-2 2013 The polyphenol (-)-epigallocatechin gallate (EGCG) was recently reported to inhibit Abeta fibrillization and redirect Abeta aggregation into unstructured, off-pathway oligomers. epigallocatechin gallate 45-49 amyloid beta precursor protein Homo sapiens 84-89 23537203-2 2013 The polyphenol (-)-epigallocatechin gallate (EGCG) was recently reported to inhibit Abeta fibrillization and redirect Abeta aggregation into unstructured, off-pathway oligomers. epigallocatechin gallate 45-49 amyloid beta precursor protein Homo sapiens 118-123 23537203-3 2013 Given the experimental challenge to characterize the structures of Abeta/EGCG complexes, we performed extensive atomistic replica exchange molecular dynamics simulations of Abeta1-42 dimer in the present and absence of EGCG in explicit solvent. epigallocatechin gallate 73-77 amyloid beta precursor protein Homo sapiens 67-72 23537203-4 2013 Our equilibrium Abeta dimeric structures free of EGCG are consistent with the collision cross section from ion-mobility mass spectrometry and the secondary structure composition from circular dichroism experiment. epigallocatechin gallate 49-53 amyloid beta precursor protein Homo sapiens 16-21 23537203-5 2013 In the presence of EGCG, the Abeta structures are characterized by increased inter-center-of-mass distances, reduced interchain and intrachain contacts, reduced beta-sheet content, and increased coil and alpha-helix contents. epigallocatechin gallate 19-23 amyloid beta precursor protein Homo sapiens 29-34 23537203-6 2013 Analysis of the free energy surfaces reveals that the Abeta dimer with EGCG adopts new conformations, affecting therefore its propensity to adopt fibril-prone states. epigallocatechin gallate 71-75 amyloid beta precursor protein Homo sapiens 54-59 23537203-7 2013 Overall, this study provides, for the first time, insights on the equilibrium structures of Abeta1-42 dimer in explicit aqueous solution and an atomic picture of the EGCG-mediated conformational change on Abeta dimer. epigallocatechin gallate 166-170 amyloid beta precursor protein Homo sapiens 92-97 23276205-0 2013 Surface plasmon resonance imaging of amyloid-beta aggregation kinetics in the presence of epigallocatechin gallate and metals. epigallocatechin gallate 90-114 amyloid beta precursor protein Homo sapiens 37-49 23426629-4 2013 We found that EGCG interacted with metal-Abeta species and formed small, unstructured Abeta aggregates more noticeably than in metal-free conditions in vitro. epigallocatechin gallate 14-18 amyloid beta precursor protein Homo sapiens 41-46 23426629-4 2013 We found that EGCG interacted with metal-Abeta species and formed small, unstructured Abeta aggregates more noticeably than in metal-free conditions in vitro. epigallocatechin gallate 14-18 amyloid beta precursor protein Homo sapiens 86-91 23426629-5 2013 In addition, upon incubation with EGCG, the toxicity presented by metal-free Abeta and metal-Abeta was mitigated in living cells. epigallocatechin gallate 34-38 amyloid beta precursor protein Homo sapiens 77-82 23426629-5 2013 In addition, upon incubation with EGCG, the toxicity presented by metal-free Abeta and metal-Abeta was mitigated in living cells. epigallocatechin gallate 34-38 amyloid beta precursor protein Homo sapiens 93-98 23426629-7 2013 These studies indicated that (i) EGCG was bound to Abeta monomers and dimers, generating more compact peptide conformations than those from EGCG-untreated Abeta species; and (ii) ternary EGCG-metal-Abeta complexes were produced. epigallocatechin gallate 33-37 amyloid beta precursor protein Homo sapiens 51-56 23426629-7 2013 These studies indicated that (i) EGCG was bound to Abeta monomers and dimers, generating more compact peptide conformations than those from EGCG-untreated Abeta species; and (ii) ternary EGCG-metal-Abeta complexes were produced. epigallocatechin gallate 33-37 amyloid beta precursor protein Homo sapiens 155-160 23426629-7 2013 These studies indicated that (i) EGCG was bound to Abeta monomers and dimers, generating more compact peptide conformations than those from EGCG-untreated Abeta species; and (ii) ternary EGCG-metal-Abeta complexes were produced. epigallocatechin gallate 33-37 amyloid beta precursor protein Homo sapiens 155-160 23426629-8 2013 Thus, we demonstrate the distinct antiamyloidogenic reactivity of EGCG toward metal-Abeta species with a structure-based mechanism. epigallocatechin gallate 66-70 amyloid beta precursor protein Homo sapiens 84-89 23443273-3 2013 We have demonstrated here the electrochemical properties of a green tea component, (-)-epigallocatechin-3-gallate (EGCG), and its potent activity on Abeta peptides. epigallocatechin gallate 83-113 amyloid beta precursor protein Homo sapiens 149-154 23443273-3 2013 We have demonstrated here the electrochemical properties of a green tea component, (-)-epigallocatechin-3-gallate (EGCG), and its potent activity on Abeta peptides. epigallocatechin gallate 115-119 amyloid beta precursor protein Homo sapiens 149-154 23443273-4 2013 Characterization of early interactions (<=48 h) between EGCG and Abeta was conducted using square wave voltammetry (SWV). epigallocatechin gallate 59-63 amyloid beta precursor protein Homo sapiens 68-73 23276205-4 2013 In this surface plasmon resonance imaging (SPRi) study, we have shown that the fibril seeds formed with the incubation of Abeta in the presence of metals are better at promoting monomer elongation compared to Abeta alone or in the presence of a well-described polyphenol, (-)-epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 272-302 amyloid beta precursor protein Homo sapiens 122-127 23276205-4 2013 In this surface plasmon resonance imaging (SPRi) study, we have shown that the fibril seeds formed with the incubation of Abeta in the presence of metals are better at promoting monomer elongation compared to Abeta alone or in the presence of a well-described polyphenol, (-)-epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 304-308 amyloid beta precursor protein Homo sapiens 122-127 22300765-0 2012 Structural properties of EGCG-induced, nontoxic Alzheimer"s disease Abeta oligomers. epigallocatechin gallate 25-29 amyloid beta precursor protein Homo sapiens 68-73 22300765-1 2012 The green tea compound epigallocatechin-3-gallate (EGCG) inhibits Alzheimer"s disease beta-amyloid peptide (Abeta) neurotoxicity. epigallocatechin gallate 23-49 amyloid beta precursor protein Homo sapiens 86-106 22300765-1 2012 The green tea compound epigallocatechin-3-gallate (EGCG) inhibits Alzheimer"s disease beta-amyloid peptide (Abeta) neurotoxicity. epigallocatechin gallate 23-49 amyloid beta precursor protein Homo sapiens 108-113 22300765-1 2012 The green tea compound epigallocatechin-3-gallate (EGCG) inhibits Alzheimer"s disease beta-amyloid peptide (Abeta) neurotoxicity. epigallocatechin gallate 51-55 amyloid beta precursor protein Homo sapiens 86-106 22300765-1 2012 The green tea compound epigallocatechin-3-gallate (EGCG) inhibits Alzheimer"s disease beta-amyloid peptide (Abeta) neurotoxicity. epigallocatechin gallate 51-55 amyloid beta precursor protein Homo sapiens 108-113 22300765-2 2012 Solution-state NMR allows probing initial EGCG-Abeta interactions. epigallocatechin gallate 42-46 amyloid beta precursor protein Homo sapiens 47-52 22300765-3 2012 We show that EGCG-induced Abeta oligomers adopt a well-defined structure and are amenable for magic angle spinning solid-state NMR investigations. epigallocatechin gallate 13-17 amyloid beta precursor protein Homo sapiens 26-31 22300765-4 2012 We find that EGCG interferes with the aromatic hydrophobic core of Abeta. epigallocatechin gallate 13-17 amyloid beta precursor protein Homo sapiens 67-72 21434871-8 2011 Furthermore, Abeta-induced mitochondrial dysfunction, impairment of NMDA Ca2+ influx and ROS production were prevented by pre-treatment of neurons with EGCG [(-)-epigallocatechin-3-gallate], a major polyphenolic component of green tea. epigallocatechin gallate 152-156 amyloid beta precursor protein Homo sapiens 13-18 22029866-0 2012 670 nm laser light and EGCG complementarily reduce amyloid-beta aggregates in human neuroblastoma cells: basis for treatment of Alzheimer"s disease? epigallocatechin gallate 23-27 amyloid beta precursor protein Homo sapiens 51-63 21605053-5 2011 In particular, we have reported that polyphenols extracted from green tea (i.e. epigallocatechin gallate or EGCG) and red wine (i.e. resveratrol) block Abeta-induced hippocampal cell death, by at least partially inhibiting Abeta fibrillisation. epigallocatechin gallate 80-104 amyloid beta precursor protein Homo sapiens 152-157 21605053-5 2011 In particular, we have reported that polyphenols extracted from green tea (i.e. epigallocatechin gallate or EGCG) and red wine (i.e. resveratrol) block Abeta-induced hippocampal cell death, by at least partially inhibiting Abeta fibrillisation. epigallocatechin gallate 80-104 amyloid beta precursor protein Homo sapiens 223-228 21605053-5 2011 In particular, we have reported that polyphenols extracted from green tea (i.e. epigallocatechin gallate or EGCG) and red wine (i.e. resveratrol) block Abeta-induced hippocampal cell death, by at least partially inhibiting Abeta fibrillisation. epigallocatechin gallate 108-112 amyloid beta precursor protein Homo sapiens 152-157 21605053-5 2011 In particular, we have reported that polyphenols extracted from green tea (i.e. epigallocatechin gallate or EGCG) and red wine (i.e. resveratrol) block Abeta-induced hippocampal cell death, by at least partially inhibiting Abeta fibrillisation. epigallocatechin gallate 108-112 amyloid beta precursor protein Homo sapiens 223-228 21434871-8 2011 Furthermore, Abeta-induced mitochondrial dysfunction, impairment of NMDA Ca2+ influx and ROS production were prevented by pre-treatment of neurons with EGCG [(-)-epigallocatechin-3-gallate], a major polyphenolic component of green tea. epigallocatechin gallate 158-188 amyloid beta precursor protein Homo sapiens 13-18 21434871-9 2011 Taken together, these results support a role for NADPH oxidase-mediated ROS production in the cytotoxic effects of Abeta, and demonstrate the therapeutic potential of EGCG and other dietary polyphenols in delaying onset or retarding the progression of AD. epigallocatechin gallate 167-171 amyloid beta precursor protein Homo sapiens 115-120 16177050-3 2005 Here, we report that (-)-epigallocatechin-3-gallate (EGCG), the main polyphenolic constituent of green tea, reduces Abeta generation in both murine neuron-like cells (N2a) transfected with the human "Swedish" mutant amyloid precursor protein (APP) and in primary neurons derived from Swedish mutant APP-overexpressing mice (Tg APPsw line 2576). epigallocatechin gallate 23-51 amyloid beta precursor protein Homo sapiens 216-241 16539659-0 2006 Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer"s disease. epigallocatechin gallate 82-112 amyloid beta precursor protein Homo sapiens 28-53 16539659-0 2006 Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer"s disease. epigallocatechin gallate 82-112 amyloid beta precursor protein Homo sapiens 58-78 17590240-5 2009 We demonstrated that treatment with EGCG reduced the A beta levels by enhancing endogenous APP nonamyloidogenic proteolytic processing. epigallocatechin gallate 36-40 amyloid beta precursor protein Homo sapiens 53-59 16539659-7 2006 Furthermore, EGCG reduced toxic beta-amyloid peptide generation in Chinese hamster ovary cells overexpressing the APP "Swedish" mutation. epigallocatechin gallate 13-17 amyloid beta precursor protein Homo sapiens 32-52 16177050-3 2005 Here, we report that (-)-epigallocatechin-3-gallate (EGCG), the main polyphenolic constituent of green tea, reduces Abeta generation in both murine neuron-like cells (N2a) transfected with the human "Swedish" mutant amyloid precursor protein (APP) and in primary neurons derived from Swedish mutant APP-overexpressing mice (Tg APPsw line 2576). epigallocatechin gallate 53-57 amyloid beta precursor protein Homo sapiens 216-241 34884584-3 2021 Abeta fibrils were reported to be disaggregated by treatment with small compounds, such as epigallocatechin gallate (EGCG) and dopamine (DA), and a loss of fibril shape and decrease in cytotoxicity were observed. epigallocatechin gallate 91-115 amyloid beta precursor protein Homo sapiens 0-5 12670874-3 2003 The present study shows that EGCG enhances (approximately 6-fold) the release of the non-amyloidogenic soluble form of the amyloid precursor protein (sAPPalpha) into the conditioned media of human SH-SY5Y neuroblastoma and rat pheochromocytoma PC12 cells. epigallocatechin gallate 29-33 amyloid beta precursor protein Homo sapiens 123-148 34884584-3 2021 Abeta fibrils were reported to be disaggregated by treatment with small compounds, such as epigallocatechin gallate (EGCG) and dopamine (DA), and a loss of fibril shape and decrease in cytotoxicity were observed. epigallocatechin gallate 117-121 amyloid beta precursor protein Homo sapiens 0-5 34884584-6 2021 A cytotoxicity assay revealed that Abeta fibrils incubated with a low concentration of EGCG and DA showed higher cytotoxicity than Abeta fibrils alone. epigallocatechin gallate 87-91 amyloid beta precursor protein Homo sapiens 35-40 34225874-4 2021 The triple targeting liposomes boosted the capability of CURC, QU, EGCG and RA for crossing the BBB with the assistance of grafted GSH and ApoE and docking Abeta around SK-N-MC cells using ApoE and PC. epigallocatechin gallate 67-71 amyloid beta precursor protein Homo sapiens 156-161 34554735-6 2021 Various Abeta fibril samples that differed by their length were produced by sonication of fibrils obtained in the presence of epigallocatechin gallate. epigallocatechin gallate 126-150 amyloid beta precursor protein Homo sapiens 8-13 34594185-7 2021 There is evidence for EGCG"s ability to inhibit the aggregation of alpha-synuclein, amyloid-beta, and huntingtin proteins, respectively associated with PD, AD, and HD. epigallocatechin gallate 22-26 amyloid beta precursor protein Homo sapiens 84-96 34065606-3 2021 Several studies have shown that EGCG interacts with misfolded proteins such as amyloid beta-peptide (Abeta), linked to Alzheimer"s disease (AD), and alpha-synuclein, linked to Parkinson"s disease (PD). epigallocatechin gallate 32-36 amyloid beta precursor protein Homo sapiens 101-106 35380783-1 2022 Epigallocatechin-3-gallate (EGCG) has been widely recognized as a potent inhibitor of Alzheimer"s amyloid-beta (Abeta) fibrillogenesis. epigallocatechin gallate 0-26 amyloid beta precursor protein Homo sapiens 98-110 35380783-1 2022 Epigallocatechin-3-gallate (EGCG) has been widely recognized as a potent inhibitor of Alzheimer"s amyloid-beta (Abeta) fibrillogenesis. epigallocatechin gallate 0-26 amyloid beta precursor protein Homo sapiens 112-117 35380783-1 2022 Epigallocatechin-3-gallate (EGCG) has been widely recognized as a potent inhibitor of Alzheimer"s amyloid-beta (Abeta) fibrillogenesis. epigallocatechin gallate 28-32 amyloid beta precursor protein Homo sapiens 98-110 35380783-1 2022 Epigallocatechin-3-gallate (EGCG) has been widely recognized as a potent inhibitor of Alzheimer"s amyloid-beta (Abeta) fibrillogenesis. epigallocatechin gallate 28-32 amyloid beta precursor protein Homo sapiens 112-117 32579965-3 2020 In this study, we investigate the interactions of epigallocatechin-3-gallate (EGCG), found in green tea, with Abeta polypeptides, using a combination of in vitro immuno-infrared sensor measurements, docking, molecular dynamics simulations, and ab initio calculations. epigallocatechin gallate 50-76 amyloid beta precursor protein Homo sapiens 110-115 35068066-0 2022 Epigallocatechin Gallate Reduces Amyloid beta-Induced Neurotoxicity via Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis. epigallocatechin gallate 0-24 amyloid beta precursor protein Homo sapiens 33-45 32905372-3 2020 Epigallocatechin gallate (EGCG), the main polyphenol in green tea, has been generally considered an inhibitor of Abeta aggregation. epigallocatechin gallate 0-24 amyloid beta precursor protein Homo sapiens 113-118 32905372-3 2020 Epigallocatechin gallate (EGCG), the main polyphenol in green tea, has been generally considered an inhibitor of Abeta aggregation. epigallocatechin gallate 26-30 amyloid beta precursor protein Homo sapiens 113-118 32751722-4 2020 The central core region of the amyloid-beta (Abeta(1-40)) fibril is found to have a high affinity to EGCG and CUR due to the presence of hydrophobic residues. epigallocatechin gallate 101-105 amyloid beta precursor protein Homo sapiens 31-43 32579965-3 2020 In this study, we investigate the interactions of epigallocatechin-3-gallate (EGCG), found in green tea, with Abeta polypeptides, using a combination of in vitro immuno-infrared sensor measurements, docking, molecular dynamics simulations, and ab initio calculations. epigallocatechin gallate 78-82 amyloid beta precursor protein Homo sapiens 110-115 32579965-4 2020 We find that the interactions of EGCG are dominated by only a few residues in the fibrils, including hydrophobic pi-pi interactions with aromatic rings of side chains and hydrophilic interactions with the backbone of Abeta, as confirmed by extended (1-mus-long) molecular dynamics simulations. epigallocatechin gallate 33-37 amyloid beta precursor protein Homo sapiens 217-222 32579965-5 2020 Immuno-infrared sensor data are consistent with degradation of Abeta fibril induced by EGCG and inhibition of Abeta fibril and oligomer formation, as manifested by the recovery of the amide-I band of monomeric Abeta, which is red-shifted by 26 cm-1 when compared to the amide-I band of the fibrillar form. epigallocatechin gallate 87-91 amyloid beta precursor protein Homo sapiens 63-68 32441920-3 2020 Increasing evidence shows that green tea extracts, epigallocatechin-3-gallate (EGCG, containing an extra gallic acid ester group compared to EGC) and epigallocatechin (EGC), can disassociate Abeta fibrils and attenuate Abeta toxicity. epigallocatechin gallate 51-77 amyloid beta precursor protein Homo sapiens 191-196 32441920-3 2020 Increasing evidence shows that green tea extracts, epigallocatechin-3-gallate (EGCG, containing an extra gallic acid ester group compared to EGC) and epigallocatechin (EGC), can disassociate Abeta fibrils and attenuate Abeta toxicity. epigallocatechin gallate 79-83 amyloid beta precursor protein Homo sapiens 191-196 32441920-9 2020 This study demonstrates the pivotal role of gallic acid ester group of EGCG in disrupting Abeta42 protofibril and provides atomic-level insights into the distinct mechanism by which EGCG and EGC disrupt Abeta protofibril, which could be useful for designing amyloid inhibitors. epigallocatechin gallate 71-75 amyloid beta precursor protein Homo sapiens 90-95 32441920-9 2020 This study demonstrates the pivotal role of gallic acid ester group of EGCG in disrupting Abeta42 protofibril and provides atomic-level insights into the distinct mechanism by which EGCG and EGC disrupt Abeta protofibril, which could be useful for designing amyloid inhibitors. epigallocatechin gallate 182-186 amyloid beta precursor protein Homo sapiens 90-95 30660780-3 2019 Among the isolates, three tea polyphenols, including (-)-catechin gallate (CG), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), significantly decreased Abeta aggregation at a concentration of 10 mug ml-1, compared to the positive control, Abeta alone. epigallocatechin gallate 115-143 amyloid beta precursor protein Homo sapiens 176-181