PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15473697-5 2004 Although the overall structural topology between BACE1 and BACE2 protease domains is quite similar, the former contains 3 disulfide bonds but the latter only two. Disulfides 122-131 beta-secretase 2 Homo sapiens 59-64 10965118-5 2000 In addition, and similarly to BACE, BACE2 differs from the other members of the human aspartic protease family in the number and distribution of putative disulfide bonds and in the presence of an extended C-terminal region which contains a predicted transmembrane segment. Disulfides 154-163 beta-secretase 2 Homo sapiens 36-41