PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22933628-0	2012	Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus.	pristane	74-82	interferon regulatory factor 5	Mus musculus	15-19	
22933628-4	2012	In the present study, we examined the mechanisms by which loss of Irf5 protects mice from pristane-induced lupus at early time points of disease development.	pristane	90-98	interferon regulatory factor 5	Mus musculus	66-70	
22933628-6	2012	Chemotaxis assays using peritoneal lavage from pristane-injected Irf5(+/+) and Irf5(-/-) littermates support an intrinsic defect in Irf5(-/-) monocytes.	pristane	47-55	interferon regulatory factor 5	Mus musculus	65-69	
22678902-0	2012	Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching.	pristane	39-47	interferon regulatory factor 5	Mus musculus	0-4	
22678902-3	2012	Here, we demonstrate that IRF5 is required for pristane-induced SLE via its ability to control multiple facets of autoimmunity.	pristane	47-55	interferon regulatory factor 5	Mus musculus	26-30	
22422888-2	2012	In this study, we examined the role of IRF5 in the pathogenesis of pristane-induced lupus in mice.	pristane	67-75	interferon regulatory factor 5	Mus musculus	39-43	
22422888-3	2012	The pathological response to pristane in IRF5(-/-) mice shared many features with type I IFN receptor (IFNAR)(-/-) and TLR7(-/-) mice: production of anti-Sm/RNP autoantibodies, glomerulonephritis, generation of Ly6C(hi) monocytes, and IFN-I production all were greatly attenuated.	pristane	29-37	interferon regulatory factor 5	Mus musculus	41-45	
22422888-4	2012	Lymphocyte activation following pristane injection was greatly diminished in IRF5(-/-) mice, and Th cell differentiation was deviated from Th1 in wild-type mice toward Th2 in IRF5(-/-) mice.	pristane	32-40	interferon regulatory factor 5	Mus musculus	77-81	
22933628-8	2012	Bone marrow reconstitution experiments further supported an intrinsic defect in Irf5(-/-) monocytes because Irf5(+/+) monocytes were preferentially recruited to the peritoneal cavity in response to pristane.	pristane	198-206	interferon regulatory factor 5	Mus musculus	108-112	
22933628-9	2012	Taken together, these findings demonstrate an intrinsic role for IRF5 in the response of monocytes to pristane and their recruitment to the primary site of inflammation that is thought to trigger lupus onset in this experimental model of SLE.	pristane	102-110	interferon regulatory factor 5	Mus musculus	65-69	
22422888-9	2012	Collectively, these data indicate that altered production of IFN-I and other cytokines in IRF5(-/-) mice prevents pristane from inducing lupus pathology by broadly affecting T and B lymphocyte activation/differentiation.	pristane	114-122	interferon regulatory factor 5	Mus musculus	90-94