PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8248926-4	1993	A polyclonal antibody raised against CYP4B1 prevented the covalent binding of [14C]-ipomeanol to lung microsomal protein in vitro.	4-ipomeanol	84-93	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	37-43	
8248926-0	1993	CYP4B1 activates 4-ipomeanol in rat lung.	4-ipomeanol	17-28	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	0-6	
8248926-1	1993	Inhibition of pulmonary CYP4B1 activity by pretreatment of rats with p-xylene decreased the ability of lung microsomes to N-hydroxylate 2-aminofluorene and prevented the lung damage normally seen after dosing with ipomeanol.	4-ipomeanol	214-223	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	24-30	
8248926-7	1993	The CYP4B1 substrate 2-aminofluorene, when dosed to rats, caused a sixfold decrease in ipomeanol toxicity.	4-ipomeanol	87-96	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	4-10	
24899949-1	2010	OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy.	4-ipomeanol	92-103	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	53-72	
23682585-0	2013	Synthesis and evaluation of a 18F-labeled 4-ipomeanol as an imaging agent for CYP4B1 gene prodrug activation therapy.	4-ipomeanol	42-53	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	78-84	
23682585-1	2013	We report the development of a (18)F-labeled 4-ipomeanol (4-IM), which is metabolized by the CYP4B1 enzyme, to image tumors and monitor enzyme-activating anticancer prodrugs.	4-ipomeanol	45-56	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	93-99	
23682585-1	2013	We report the development of a (18)F-labeled 4-ipomeanol (4-IM), which is metabolized by the CYP4B1 enzyme, to image tumors and monitor enzyme-activating anticancer prodrugs.	4-ipomeanol	58-62	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	93-99	
24899949-1	2010	OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy.	4-ipomeanol	105-110	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	53-72	
24899949-1	2010	OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy.	4-ipomeanol	105-110	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	74-80	
24899949-1	2010	OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy.	4-ipomeanol	92-103	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	74-80	
24899949-1	2010	OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy.	4-ipomeanol	92-97	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	53-72	
24899949-1	2010	OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy.	4-ipomeanol	92-97	cytochrome P450, family 4, subfamily b, polypeptide 1	Rattus norvegicus	74-80