PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10917203-2	2000	As demonstrated recently, the novel prodrug activating gene coding for rabbit cytochrome P450 4B1 (CYP4B1) is able to induce tumor cell death at low micromolar concentrations in glioblastoma cells after treatment with the prodrug 4-ipomeanol (4-IM) in vitro and in vivo.	4-ipomeanol	230-241	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	99-105	
12894565-0	2003	Combined radiation and cytochrome CYP4B1/4-ipomeanol gene therapy using the EGR1 promoter.	4-ipomeanol	43-52	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	34-42	
12894565-1	2003	BACKGROUND: Cytochrome p450 isozyme CYP4B1 converts the inert prodrug 4-ipomeanol (4-IM) into toxic alkylating metabolites.	4-ipomeanol	70-81	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	36-42	
12894565-1	2003	BACKGROUND: Cytochrome p450 isozyme CYP4B1 converts the inert prodrug 4-ipomeanol (4-IM) into toxic alkylating metabolites.	4-ipomeanol	83-87	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	36-42	
10917203-2	2000	As demonstrated recently, the novel prodrug activating gene coding for rabbit cytochrome P450 4B1 (CYP4B1) is able to induce tumor cell death at low micromolar concentrations in glioblastoma cells after treatment with the prodrug 4-ipomeanol (4-IM) in vitro and in vivo.	4-ipomeanol	243-247	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	99-105	
7503758-6	1995	Cytochrome P450 4B1 activity was assessed by the cytotoxicity of 4-ipomeanol, a known substrate for P450 4B1 and a model compound for chemical-induced injury to the lung.	4-ipomeanol	65-76	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	0-19	
23748241-0	2013	Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.	4-ipomeanol	112-121	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	37-43	
23748241-0	2013	Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.	4-ipomeanol	112-121	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	71-77	
23748241-2	2013	CYP4B1 is a pulmonary enzyme that has been shown, in vitro, to have a high capacity for bioactivating IPO.	4-ipomeanol	102-105	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	0-6	
23748241-5	2013	Pulmonary and renal microsomes prepared from male Cyp4b1 (-/-) mice exhibited no detectable expression of the protein and catalyzed the in vitro bioactivation of IPO at < 10% of the rates observed in tissue microsomes from Cyp4b1 (+/+) animals.	4-ipomeanol	162-165	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	50-56	
23748241-5	2013	Pulmonary and renal microsomes prepared from male Cyp4b1 (-/-) mice exhibited no detectable expression of the protein and catalyzed the in vitro bioactivation of IPO at < 10% of the rates observed in tissue microsomes from Cyp4b1 (+/+) animals.	4-ipomeanol	162-165	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	226-232	
23748241-6	2013	Administration of IPO (20mg/kg) to Cyp4b1 (+/+) mice resulted in characteristic lesions in the lung, and to a lesser extent in the kidney, which were completely absent in Cyp4b1 (-/-) mice.	4-ipomeanol	18-21	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	35-41	
23748241-6	2013	Administration of IPO (20mg/kg) to Cyp4b1 (+/+) mice resulted in characteristic lesions in the lung, and to a lesser extent in the kidney, which were completely absent in Cyp4b1 (-/-) mice.	4-ipomeanol	18-21	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	171-177	
23748241-7	2013	We conclude that CYP4B1 is a critical enzyme for the bioactivation of IPO in vivo and that the Cyp4b1 (-/-) mouse is a useful model for studying CYP4B1-dependent metabolism and toxicity.	4-ipomeanol	70-73	cytochrome P450, family 4, subfamily b, polypeptide 1	Mus musculus	17-23