PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7351618-2 1980 Although it is not yet known whether cytochrome P-450 and benzphetamine demethylase activities are present in substantial amounts in more than one lung cell type in mice or rats, previous studies have indicated that cytochrome P-450 enzymes located in pulmonary bronchiolar Clara cells of these mediate the covalent binding of 4-ipomeanol to lung macromolecules. 4-ipomeanol 327-338 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 216-232 3168078-6 1988 Incubations of the lung, the nasal olfactory mucosa, the hard palate and the liver in CO- or N2-atmospheres or in the presence of the cytochrome P-450-inhibitor metyrapone showed decreased formation of tissue-bound 3H from the 3H-labelled 4-ipomeanol, indicating a role of cytochrome P-450 in the metabolism of 4-ipomeanol in the various tissues. 4-ipomeanol 239-250 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 134-150 3168078-6 1988 Incubations of the lung, the nasal olfactory mucosa, the hard palate and the liver in CO- or N2-atmospheres or in the presence of the cytochrome P-450-inhibitor metyrapone showed decreased formation of tissue-bound 3H from the 3H-labelled 4-ipomeanol, indicating a role of cytochrome P-450 in the metabolism of 4-ipomeanol in the various tissues. 4-ipomeanol 311-322 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 134-150