PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16877261-3 2006 CYP4B1 also participates in the metabolism of certain xenobiotics that are protoxic, including valproic acid, 3-methylindole, 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and numerous aromatic amines. 4-ipomeanol 126-137 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 0-6 12639503-1 2003 CYP4B1 isoforms from rodents and other common laboratory animals are involved in the bioactivation of a range of protoxins, including 2-aminofluorene, 4-ipomeanol, and valproic acid. 4-ipomeanol 151-162 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 0-6 31799839-0 2019 Structure-Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates. 4-ipomeanol 61-72 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 37-43 10830728-3 2000 Ganciclovir and 4-ipomeanol sensitivity was comparable with that achieved with the native HSV-TK and CYP4B1 proteins. 4-ipomeanol 16-27 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 101-107 1651809-6 1991 CYP2F1 and CYP4B1, two enzymes that are expressed in lung, display only modest 3- and 2-fold respective increased abilities to metabolically activate 4-ipomeanol. 4-ipomeanol 150-161 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 11-17 31801692-2 2020 A prominent CYP4B1 substrate is the furan pro-toxin 4-ipomeanol (IPO). 4-ipomeanol 65-68 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 12-18 10917203-7 2000 4-IM rapidly induced tumor cell death in CYP4B1-EGFP-expressing clones at low concentrations (a 50% lethal dose of between 0.5 and 2 microg/mL). 4-ipomeanol 0-4 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 41-47 31799839-1 2019 Cytochrome P450 4B1 (CYP4B1) has been explored as a candidate enzyme in suicide gene systems for its ability to bioactivate the natural product 4-ipomeanol (IPO) to a reactive species that causes cytotoxicity. 4-ipomeanol 144-155 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 0-19 31799839-1 2019 Cytochrome P450 4B1 (CYP4B1) has been explored as a candidate enzyme in suicide gene systems for its ability to bioactivate the natural product 4-ipomeanol (IPO) to a reactive species that causes cytotoxicity. 4-ipomeanol 144-155 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 21-27 31799839-1 2019 Cytochrome P450 4B1 (CYP4B1) has been explored as a candidate enzyme in suicide gene systems for its ability to bioactivate the natural product 4-ipomeanol (IPO) to a reactive species that causes cytotoxicity. 4-ipomeanol 157-160 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 0-19 31799839-1 2019 Cytochrome P450 4B1 (CYP4B1) has been explored as a candidate enzyme in suicide gene systems for its ability to bioactivate the natural product 4-ipomeanol (IPO) to a reactive species that causes cytotoxicity. 4-ipomeanol 157-160 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 21-27 31799839-2 2019 However, metabolic limitations of IPO necessitate discovery of new "pro-toxicant" substrates for CYP4B1. 4-ipomeanol 34-37 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 97-103 30409834-1 2019 A potential CYP4B1 suicide gene application in engineered T-cell treatment of blood cancers has revived interest in the use of 4-ipomeanol (IPO) in gene-directed enzyme prodrug therapy, in which disposition of the administered compound may be critical. 4-ipomeanol 127-138 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 12-18 30409834-1 2019 A potential CYP4B1 suicide gene application in engineered T-cell treatment of blood cancers has revived interest in the use of 4-ipomeanol (IPO) in gene-directed enzyme prodrug therapy, in which disposition of the administered compound may be critical. 4-ipomeanol 140-143 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 12-18 30409834-2 2019 IPO contains one chiral center at the carbon bearing a secondary alcohol group; it was of interest to determine the effect of stereochemistry on 1) CYP4B1-mediated bioactivation and 2) (UGT)-mediated glucuronidation. 4-ipomeanol 0-3 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 148-154 28073960-1 2017 Human CYP4B1, a cytochrome P450 monooxygenase predominantly expressed in the lung, inefficiently metabolizes classical CYP4B1 substrates, such as the naturally occurring furan pro-toxin 4-ipomeanol (4-IPO). 4-ipomeanol 186-197 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 6-12 28073960-1 2017 Human CYP4B1, a cytochrome P450 monooxygenase predominantly expressed in the lung, inefficiently metabolizes classical CYP4B1 substrates, such as the naturally occurring furan pro-toxin 4-ipomeanol (4-IPO). 4-ipomeanol 186-197 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 119-125 28073960-1 2017 Human CYP4B1, a cytochrome P450 monooxygenase predominantly expressed in the lung, inefficiently metabolizes classical CYP4B1 substrates, such as the naturally occurring furan pro-toxin 4-ipomeanol (4-IPO). 4-ipomeanol 199-204 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 6-12 28073960-1 2017 Human CYP4B1, a cytochrome P450 monooxygenase predominantly expressed in the lung, inefficiently metabolizes classical CYP4B1 substrates, such as the naturally occurring furan pro-toxin 4-ipomeanol (4-IPO). 4-ipomeanol 199-204 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 119-125 28073960-3 2017 By substitution of 13 amino acids, we restored the enzymatic activity of human CYP4B1 toward 4-IPO and this modified cDNA is potentially valuable as a suicide gene for adoptive T-cell therapies. 4-ipomeanol 93-98 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 79-85 27092941-6 2016 Finally, 4-ipomeanol efficiently induced apoptosis in primary T cells that co-express mutant CYP4B1 and the divergently located MACS selection and CAR genes. 4-ipomeanol 9-20 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 93-99 25247810-0 2015 Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. 4-ipomeanol 88-99 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 45-51 25247810-1 2015 Mammalian CYP4B1 enzymes are cytochrome P450 mono-oxygenases that are responsible for the bioactivation of several exogenous pro-toxins including 4-ipomeanol (4-IPO). 4-ipomeanol 146-157 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 10-16 25247810-1 2015 Mammalian CYP4B1 enzymes are cytochrome P450 mono-oxygenases that are responsible for the bioactivation of several exogenous pro-toxins including 4-ipomeanol (4-IPO). 4-ipomeanol 159-164 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 10-16 25247810-2 2015 In contrast with the orthologous rabbit enzyme, we show here that native human CYP4B1 with a serine residue at position 427 is unable to bioactivate 4-IPO and does not cause cytotoxicity in HepG2 cells and primary human T-cells that overexpress these enzymes. 4-ipomeanol 149-154 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 79-85 25247810-3 2015 We also demonstrate that a proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-IPO bioactivation of the human enzyme, but is not essential for the catalytic activity of the rabbit CYP4B1 protein. 4-ipomeanol 173-178 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 90-96 25247810-4 2015 Systematic substitution of native and p.S427P human CYP4B1 with peptide regions from the highly active rabbit enzyme reveals that 18 amino acids in the wild-type rabbit CYP4B1 protein are key for conferring high 4-IPO metabolizing activity. 4-ipomeanol 212-217 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 52-58 25247810-7 2015 Finally, by minimally re-engineering the human CYP4B1 enzyme for efficient activation of 4-IPO, we have developed a novel human suicide gene system that is a candidate for adoptive cellular therapies in humans. 4-ipomeanol 89-94 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 47-53