PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31020694-6	2019	We used human CC cell line JEG-3 to establish cell lines resistant to methotrexate and 5-fluorouracil (JEG-3/MTX and JEG-3/5-FU) and detected the expression of H19 in JEG-3, JEG-3/MTX, JEG-3/5-FU cells, JEG-3 with MTX, and JEG-3 with 5-FU.	Methotrexate	180-183	H19 imprinted maternally expressed transcript	Homo sapiens	160-163	
33667788-5	2021	Paclitaxel, doxorubicin, tamoxifen, erlotinib, gefitinib, temozolomide, and methotrexate are among therapeutic agents whose efficacy is influenced by the expression of H19.	Methotrexate	76-88	H19 imprinted maternally expressed transcript	Homo sapiens	168-171	
31020694-6	2019	We used human CC cell line JEG-3 to establish cell lines resistant to methotrexate and 5-fluorouracil (JEG-3/MTX and JEG-3/5-FU) and detected the expression of H19 in JEG-3, JEG-3/MTX, JEG-3/5-FU cells, JEG-3 with MTX, and JEG-3 with 5-FU.	Methotrexate	180-183	H19 imprinted maternally expressed transcript	Homo sapiens	160-163	
31020694-7	2019	We found that the expression of H19 in the JEG-3/MTX and JEG-3/5-FU cells were significantly higher than that in JEG-3 cells.	Methotrexate	49-52	H19 imprinted maternally expressed transcript	Homo sapiens	32-35	
31020694-8	2019	JEG-3 cells were treated with MTX or 5-FU for and quantitative real-time polymerase chain reaction assay revealed that H19 messenger RNA expression increased.	Methotrexate	30-33	H19 imprinted maternally expressed transcript	Homo sapiens	119-122	
31020694-9	2019	Furthermore, after H19 was knocked out, the drug resistance index of the JEG-3/MTX and JEG-3/5-FU cells decreased; the proliferation, migration, and invasion ability diminished significantly; and apoptosis increased significantly.	Methotrexate	79-82	H19 imprinted maternally expressed transcript	Homo sapiens	19-22	
27919747-0	2017	H19 mediates methotrexate resistance in colorectal cancer through activating Wnt/beta-catenin pathway.	Methotrexate	13-25	H19 imprinted maternally expressed transcript	Homo sapiens	0-3	
27919747-9	2017	Further investigation showed that H19 knockdown sensitized the MTX resistance in HT-29-R cells while its overexpression improved the MTX resistance in the parental cells, suggesting that H19 mediate MTX resistance.	Methotrexate	63-66	H19 imprinted maternally expressed transcript	Homo sapiens	34-37	
27919747-11	2017	In conclusion, H19 mediated MTX resistance via activating Wnt/beta-catenin signaling, which help to develop H19 as a promising therapeutic target for MTX resistant CRC.	Methotrexate	28-31	H19 imprinted maternally expressed transcript	Homo sapiens	15-18	
27919747-11	2017	In conclusion, H19 mediated MTX resistance via activating Wnt/beta-catenin signaling, which help to develop H19 as a promising therapeutic target for MTX resistant CRC.	Methotrexate	28-31	H19 imprinted maternally expressed transcript	Homo sapiens	108-111	
27919747-11	2017	In conclusion, H19 mediated MTX resistance via activating Wnt/beta-catenin signaling, which help to develop H19 as a promising therapeutic target for MTX resistant CRC.	Methotrexate	150-153	H19 imprinted maternally expressed transcript	Homo sapiens	15-18	
27919747-11	2017	In conclusion, H19 mediated MTX resistance via activating Wnt/beta-catenin signaling, which help to develop H19 as a promising therapeutic target for MTX resistant CRC.	Methotrexate	150-153	H19 imprinted maternally expressed transcript	Homo sapiens	108-111