PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19181434-7	2009	The activation of caspase-9 was increased 4.35+/-0.76-fold in MTX-incubated JAR, while there was no obvious change in the activation of caspase-8.	Methotrexate	62-65	caspase 9	Homo sapiens	18-27	
19181434-9	2009	CONCLUSION: Methotrexate in lower concentrations induces apoptosis of human choriocarcinoma cells via mitochondrial-initiated pathways, including reduction of mitochondrial membrane potential, activation of caspase-9, and up-regulation of Bax/Bcl-2 expression.	Methotrexate	12-24	caspase 9	Homo sapiens	207-216	
27435483-12	2017	Protein and gene expression of cleaved caspase-9 were significantly increased after MTX treatment, whereas the expression of Bcl-xL, c-FLIP, NFkappaBp65, pAkt1 significantly downregulated after MTX treatment.	Methotrexate	84-87	caspase 9	Homo sapiens	39-48	
35385883-9	2022	TQ and MTX can induce the expression level of pro-apoptotic factors, Bax and caspase-9 while inhibiting anti-apoptotic protein BCL-2.	Methotrexate	7-10	caspase 9	Homo sapiens	77-86	
33927966-8	2021	Folate receptor targeted MTX-GNPs showed significant cellular uptake in breast cancer cells along with significant down-regulation in expression of anti-apoptotic gene (Bcl-2) and up-regulation in expression of pro-apoptotic genes (Bax, Caspase-3, Caspase-9, APAF-1, p53).	Methotrexate	25-28	caspase 9	Homo sapiens	248-257	
27435483-12	2017	Protein and gene expression of cleaved caspase-9 were significantly increased after MTX treatment, whereas the expression of Bcl-xL, c-FLIP, NFkappaBp65, pAkt1 significantly downregulated after MTX treatment.	Methotrexate	194-197	caspase 9	Homo sapiens	39-48	
24969544-6	2014	The present study showed that MTX induces increases in H2O2 levels and caspase-9/-3 activation leading to cell death in hepatocellular carcinoma Hep3B cells.	Methotrexate	30-33	caspase 9	Homo sapiens	71-80	
23406595-7	2013	RESULTS: MTX-treated NPs contained significantly increased amounts of the active forms of caspase 8, caspase 9, and caspase 3 and displayed increased cleavage of poly(ADP-ribose) polymerase.	Methotrexate	9-12	caspase 9	Homo sapiens	101-110