PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2242072-0	1990	Rescue of interleukin-1 activity by leucovorin following inhibition by methotrexate in a murine in vitro system.	Methotrexate	71-83	interleukin 1 complex	Mus musculus	10-23	
2242072-1	1990	We have recently shown that methotrexate (MTX) inhibits interleukin-1 (IL-1) activity in vitro.	Methotrexate	28-40	interleukin 1 complex	Mus musculus	56-69	
2242072-1	1990	We have recently shown that methotrexate (MTX) inhibits interleukin-1 (IL-1) activity in vitro.	Methotrexate	28-40	interleukin 1 complex	Mus musculus	71-75	
2242072-1	1990	We have recently shown that methotrexate (MTX) inhibits interleukin-1 (IL-1) activity in vitro.	Methotrexate	42-45	interleukin 1 complex	Mus musculus	56-69	
2242072-1	1990	We have recently shown that methotrexate (MTX) inhibits interleukin-1 (IL-1) activity in vitro.	Methotrexate	42-45	interleukin 1 complex	Mus musculus	71-75	
2242072-3	1990	In the present study, we showed that the inhibition of IL-1 activity in vitro by MTX is dependent on folate pathways since, after the addition of leucovorin, the inhibitory effect of MTX was abolished.	Methotrexate	81-84	interleukin 1 complex	Mus musculus	55-59	
2242072-3	1990	In the present study, we showed that the inhibition of IL-1 activity in vitro by MTX is dependent on folate pathways since, after the addition of leucovorin, the inhibitory effect of MTX was abolished.	Methotrexate	183-186	interleukin 1 complex	Mus musculus	55-59	
2784964-0	1989	The effects of methotrexate on the production and activity of interleukin-1.	Methotrexate	15-27	interleukin 1 complex	Mus musculus	62-75	
2784964-1	1989	To explore the possibility that the mechanism of action of methotrexate (MTX) in rheumatoid arthritis (RA) is related to modulation of interleukin-1 (IL-1), the effects of MTX on IL-1 production and activity were evaluated.	Methotrexate	59-71	interleukin 1 complex	Mus musculus	135-148	
2784964-1	1989	To explore the possibility that the mechanism of action of methotrexate (MTX) in rheumatoid arthritis (RA) is related to modulation of interleukin-1 (IL-1), the effects of MTX on IL-1 production and activity were evaluated.	Methotrexate	59-71	interleukin 1 complex	Mus musculus	150-154	
2784964-1	1989	To explore the possibility that the mechanism of action of methotrexate (MTX) in rheumatoid arthritis (RA) is related to modulation of interleukin-1 (IL-1), the effects of MTX on IL-1 production and activity were evaluated.	Methotrexate	59-71	interleukin 1 complex	Mus musculus	179-183	
2784964-1	1989	To explore the possibility that the mechanism of action of methotrexate (MTX) in rheumatoid arthritis (RA) is related to modulation of interleukin-1 (IL-1), the effects of MTX on IL-1 production and activity were evaluated.	Methotrexate	73-76	interleukin 1 complex	Mus musculus	135-148	
2784964-1	1989	To explore the possibility that the mechanism of action of methotrexate (MTX) in rheumatoid arthritis (RA) is related to modulation of interleukin-1 (IL-1), the effects of MTX on IL-1 production and activity were evaluated.	Methotrexate	73-76	interleukin 1 complex	Mus musculus	150-154	
2784964-1	1989	To explore the possibility that the mechanism of action of methotrexate (MTX) in rheumatoid arthritis (RA) is related to modulation of interleukin-1 (IL-1), the effects of MTX on IL-1 production and activity were evaluated.	Methotrexate	73-76	interleukin 1 complex	Mus musculus	179-183	
2784964-4	1989	We did show, however, that MTX had an inhibitory effect on IL-1 activity in 2 assays that demonstrate 2 different functions of IL-1.	Methotrexate	27-30	interleukin 1 complex	Mus musculus	59-63	
2784964-4	1989	We did show, however, that MTX had an inhibitory effect on IL-1 activity in 2 assays that demonstrate 2 different functions of IL-1.	Methotrexate	27-30	interleukin 1 complex	Mus musculus	127-131	
2784964-5	1989	In a 2-step assay using LBRM-33-1A5 (1A5) and CTLD cells, MTX inhibited the secretion of IL-2 by 1A5 lymphoma cells in response to phytohemagglutinin and IL-1.	Methotrexate	58-61	interleukin 1 complex	Mus musculus	154-158	
2784964-6	1989	In an assay using D10.G4.1 (D10) cells, MTX inhibited IL-1-induced proliferation of the D10 T cell clone.	Methotrexate	40-43	interleukin 1 complex	Mus musculus	54-58	
2784964-8	1989	The results demonstrate that MTX is capable of inhibiting some IL-1 activities without affecting IL-1 production or secretion.	Methotrexate	29-32	interleukin 1 complex	Mus musculus	63-67	
2784964-9	1989	We propose that the inhibition of IL-1 activity or IL-1-dependent events may be one of the mechanisms of action of MTX in RA.	Methotrexate	115-118	interleukin 1 complex	Mus musculus	34-38	
2784964-9	1989	We propose that the inhibition of IL-1 activity or IL-1-dependent events may be one of the mechanisms of action of MTX in RA.	Methotrexate	115-118	interleukin 1 complex	Mus musculus	51-55