PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27082452-0 2016 Estradiol and corticosterone stimulate the proliferation of a GH cell line, MtT/S: Proliferation of growth hormone cells. monooxyethylene trimethylolpropane tristearate 76-79 gonadotropin releasing hormone receptor Rattus norvegicus 62-64 27082452-0 2016 Estradiol and corticosterone stimulate the proliferation of a GH cell line, MtT/S: Proliferation of growth hormone cells. monooxyethylene trimethylolpropane tristearate 76-79 gonadotropin releasing hormone receptor Rattus norvegicus 100-114 27082452-2 2016 In this study, the involvement of these steroid hormones in the regulation of proliferation was examined in the MtT/S cells, secreting growth hormone (GH). monooxyethylene trimethylolpropane tristearate 112-115 gonadotropin releasing hormone receptor Rattus norvegicus 135-149 27082452-2 2016 In this study, the involvement of these steroid hormones in the regulation of proliferation was examined in the MtT/S cells, secreting growth hormone (GH). monooxyethylene trimethylolpropane tristearate 112-115 gonadotropin releasing hormone receptor Rattus norvegicus 151-153 20723537-8 2010 Our findings indicate that glucocorticoid regulate the expression of Syx11 and facilitate the biogenesis and the trafficking of GH-containing granules in the MtT/S cells. monooxyethylene trimethylolpropane tristearate 158-161 gonadotropin releasing hormone receptor Rattus norvegicus 128-130 22026435-3 2012 The treatment of MtT/E cells with retinoic acid resulted in a significant increase in GH mRNA and subsequently GH. monooxyethylene trimethylolpropane tristearate 17-20 gonadotropin releasing hormone receptor Rattus norvegicus 86-88 22026435-3 2012 The treatment of MtT/E cells with retinoic acid resulted in a significant increase in GH mRNA and subsequently GH. monooxyethylene trimethylolpropane tristearate 17-20 gonadotropin releasing hormone receptor Rattus norvegicus 111-113 24428719-1 2014 The regulation of transcription of the growth hormone (GH) gene by glucocorticoids was studied in MtT/S cells, a cell line derived from an oestrogen-induced mammotrophic tumour in the rat, and in the primary culture of the anterior pituitary gland of adult mice. monooxyethylene trimethylolpropane tristearate 98-101 gonadotropin releasing hormone receptor Rattus norvegicus 39-53 24428719-1 2014 The regulation of transcription of the growth hormone (GH) gene by glucocorticoids was studied in MtT/S cells, a cell line derived from an oestrogen-induced mammotrophic tumour in the rat, and in the primary culture of the anterior pituitary gland of adult mice. monooxyethylene trimethylolpropane tristearate 98-101 gonadotropin releasing hormone receptor Rattus norvegicus 55-57 24868423-10 2013 The effect of GH on cultured neuronal cells was a decrease in the MTT absorbance, suggesting a lower number of cells in a dose dependent pattern. monooxyethylene trimethylolpropane tristearate 66-69 gonadotropin releasing hormone receptor Rattus norvegicus 14-16 20723537-1 2010 Recent studies have suggested that treatment of glucocorticoid to immature growth hormone (GH)-producing cell line, MtT/S cells, dramatically induced the accumulation of GH-containing secretory granules in the cytosol and differentiated into mature GH-producing cells. monooxyethylene trimethylolpropane tristearate 116-119 gonadotropin releasing hormone receptor Rattus norvegicus 75-89 20723537-1 2010 Recent studies have suggested that treatment of glucocorticoid to immature growth hormone (GH)-producing cell line, MtT/S cells, dramatically induced the accumulation of GH-containing secretory granules in the cytosol and differentiated into mature GH-producing cells. monooxyethylene trimethylolpropane tristearate 116-119 gonadotropin releasing hormone receptor Rattus norvegicus 91-93 20723537-1 2010 Recent studies have suggested that treatment of glucocorticoid to immature growth hormone (GH)-producing cell line, MtT/S cells, dramatically induced the accumulation of GH-containing secretory granules in the cytosol and differentiated into mature GH-producing cells. monooxyethylene trimethylolpropane tristearate 116-119 gonadotropin releasing hormone receptor Rattus norvegicus 170-172 20723537-1 2010 Recent studies have suggested that treatment of glucocorticoid to immature growth hormone (GH)-producing cell line, MtT/S cells, dramatically induced the accumulation of GH-containing secretory granules in the cytosol and differentiated into mature GH-producing cells. monooxyethylene trimethylolpropane tristearate 116-119 gonadotropin releasing hormone receptor Rattus norvegicus 170-172 20723537-2 2010 However, the molecular mechanism of glucocorticoid-induced GH-containing secretory granule biogenesis in the MtT/S cells remains unknown. monooxyethylene trimethylolpropane tristearate 109-112 gonadotropin releasing hormone receptor Rattus norvegicus 59-61 20723537-5 2010 We found that the artificial elevation of GH expression in the cells did not accumulate the secretory granules in the cytosol, whereas glucocorticoid-induced the biogenesis of granules in GH-GFP-expressing MtT/S cells. monooxyethylene trimethylolpropane tristearate 206-209 gonadotropin releasing hormone receptor Rattus norvegicus 188-194 20723537-7 2010 Immunocytochemical analysis further demonstrated that Syx11 positive structures were well colocalized with GH-containing granules in both MtT/S cells and rat anterior pituitary gland. monooxyethylene trimethylolpropane tristearate 138-141 gonadotropin releasing hormone receptor Rattus norvegicus 107-109 15240998-0 2004 Effects of hormones targeting nuclear receptors on transcriptional regulation of the growth hormone gene in the MtT/S rat somatotrope cell line. monooxyethylene trimethylolpropane tristearate 112-115 gonadotropin releasing hormone receptor Rattus norvegicus 85-99 19180878-0 2008 Effect of interleukin-1 beta on growth hormone gene expression and its possible molecular mechanism in rat MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 107-110 gonadotropin releasing hormone receptor Rattus norvegicus 32-46 18058266-5 2007 In addition, GH and insulin-like growth factor I (IGF-I) stimulated the growth of MtT/E cells. monooxyethylene trimethylolpropane tristearate 82-85 gonadotropin releasing hormone receptor Rattus norvegicus 13-15 18058266-6 2007 The messenger RNAs (mRNAs) of receptors for IGF-I and GH were expressed in the MtT/E cells. monooxyethylene trimethylolpropane tristearate 79-82 gonadotropin releasing hormone receptor Rattus norvegicus 54-56 18058266-8 2007 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate 43-46 gonadotropin releasing hormone receptor Rattus norvegicus 102-104 18058266-8 2007 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate 83-86 gonadotropin releasing hormone receptor Rattus norvegicus 102-104 17090972-6 2006 In MtT/E cells, DEX, RA and 9cRA showed similar effect as observed in MtT/S cells on both GH and GHRH-receptor promoter activity. monooxyethylene trimethylolpropane tristearate 70-73 gonadotropin releasing hormone receptor Rattus norvegicus 90-92 11165046-0 2001 GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line. monooxyethylene trimethylolpropane tristearate 98-101 gonadotropin releasing hormone receptor Rattus norvegicus 0-2 11448119-0 2001 Leukaemia inhibitory factor and interleukin 6 inhibit secretion of prolactin and growth hormone by rat pituitary MtT/SM cells. monooxyethylene trimethylolpropane tristearate 113-116 gonadotropin releasing hormone receptor Rattus norvegicus 81-95 11165046-1 2001 The MtT/S somatotroph cell line should be a growth hormone-releasing hormone (GHRH)-responsive model system for the study of physiological control of growth hormone (GH) transcription because GH secretion from these cells is stimulated by GHRH. monooxyethylene trimethylolpropane tristearate 4-7 gonadotropin releasing hormone receptor Rattus norvegicus 44-58 11165046-1 2001 The MtT/S somatotroph cell line should be a growth hormone-releasing hormone (GHRH)-responsive model system for the study of physiological control of growth hormone (GH) transcription because GH secretion from these cells is stimulated by GHRH. monooxyethylene trimethylolpropane tristearate 4-7 gonadotropin releasing hormone receptor Rattus norvegicus 78-80 11165046-1 2001 The MtT/S somatotroph cell line should be a growth hormone-releasing hormone (GHRH)-responsive model system for the study of physiological control of growth hormone (GH) transcription because GH secretion from these cells is stimulated by GHRH. monooxyethylene trimethylolpropane tristearate 4-7 gonadotropin releasing hormone receptor Rattus norvegicus 166-168 11165046-10 2001 Taken together, these data indicate that although MtT/S cells express the GHRH-R, GHRH cannot stimulate adenylate cyclase to increase GH transcription due to constitutive elevation of cAMP levels, by a means that may be similar to that in cases of acromegaly not caused by oncogenic gsp mutations. monooxyethylene trimethylolpropane tristearate 50-53 gonadotropin releasing hormone receptor Rattus norvegicus 74-76 2055276-1 1991 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate 47-50 gonadotropin releasing hormone receptor Rattus norvegicus 81-95 11051049-0 2000 Insulin-like growth factor-1 causes a switch-like reduction of endogenous growth hormone mRNA in rat MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 101-104 gonadotropin releasing hormone receptor Rattus norvegicus 74-88 9886844-0 1999 Molecular mechanisms of the negative effect of insulin-like growth factor-I on growth hormone gene expression in MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 113-116 gonadotropin releasing hormone receptor Rattus norvegicus 79-93 7559079-4 1995 and Group III rats were implanted with pituitary tumors (MtT) secreting growth hormone while Group I received no further treatment after MNU. monooxyethylene trimethylolpropane tristearate 57-60 gonadotropin releasing hormone receptor Rattus norvegicus 72-86 1310694-7 1992 Four of the five MTT complexes and both in vitro Pit-1/GHF-1 complexes were reduced or eliminated by excess of an unlabeled Pit-1/GHF-1 DNA-binding site from the rat growth hormone gene, but not a mutated version of the same DNA fragment, suggesting that Pit-1/GHF-1 or a closely related thyrotroph protein binds to these DNA sequences. monooxyethylene trimethylolpropane tristearate 17-20 gonadotropin releasing hormone receptor Rattus norvegicus 166-180 1908849-2 1991 The main difference between these tumor types is that MtT/F84 secretes both growth hormone (GH) and prolactin (PRL) whereas MtT/Se secretes only GH. monooxyethylene trimethylolpropane tristearate 54-57 gonadotropin releasing hormone receptor Rattus norvegicus 76-90 1908849-2 1991 The main difference between these tumor types is that MtT/F84 secretes both growth hormone (GH) and prolactin (PRL) whereas MtT/Se secretes only GH. monooxyethylene trimethylolpropane tristearate 54-57 gonadotropin releasing hormone receptor Rattus norvegicus 92-94 1908849-2 1991 The main difference between these tumor types is that MtT/F84 secretes both growth hormone (GH) and prolactin (PRL) whereas MtT/Se secretes only GH. monooxyethylene trimethylolpropane tristearate 124-127 gonadotropin releasing hormone receptor Rattus norvegicus 145-147 2055276-1 1991 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate 47-50 gonadotropin releasing hormone receptor Rattus norvegicus 158-172 2055276-1 1991 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate 47-50 gonadotropin releasing hormone receptor Rattus norvegicus 174-176 2055276-1 1991 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate 47-50 gonadotropin releasing hormone receptor Rattus norvegicus 187-189 2055276-1 1991 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate 47-50 gonadotropin releasing hormone receptor Rattus norvegicus 187-189 2055276-6 1991 These results show that insulin and IGF-1 stimulate conversion of MtT/S cell line GH cells to PRL cells. monooxyethylene trimethylolpropane tristearate 66-69 gonadotropin releasing hormone receptor Rattus norvegicus 82-84 2055276-7 1991 This suggests that the MtT/S cell line is an excellent model system which shows the GH-cell/PRL-cell lineage. monooxyethylene trimethylolpropane tristearate 23-26 gonadotropin releasing hormone receptor Rattus norvegicus 84-86 2246332-1 1990 A Nonidet P-40 extract of growth hormone-producing rat pituitary MtT/S cells was found to contain peptidylarginine deiminase (EC 3.5.3.15), which was indistinguishable from an enzyme preparation from rat muscle in Western immunoblotting and immunoprecipitation. monooxyethylene trimethylolpropane tristearate 65-68 gonadotropin releasing hormone receptor Rattus norvegicus 26-40 2124415-4 1990 MtT/F-DMBA tumors expressed prolactin (PRL), growth hormone (GH), and adrenocorticotropin (ACTH) mRNAs. monooxyethylene trimethylolpropane tristearate 0-3 gonadotropin releasing hormone receptor Rattus norvegicus 45-59 2124415-4 1990 MtT/F-DMBA tumors expressed prolactin (PRL), growth hormone (GH), and adrenocorticotropin (ACTH) mRNAs. monooxyethylene trimethylolpropane tristearate 0-3 gonadotropin releasing hormone receptor Rattus norvegicus 61-63 2602387-0 1989 Estrogen stimulates both prolactin and growth hormone mRNAs expression in the MtT/F4 transplantable pituitary tumor. monooxyethylene trimethylolpropane tristearate 78-81 gonadotropin releasing hormone receptor Rattus norvegicus 39-53 2362633-1 1990 Intense proteinuria in rats bearing a functioning pituitary tumor MtT SA5 was considered to be evoked by overproduction of albumin due to elevated serum growth hormone (GH). monooxyethylene trimethylolpropane tristearate 66-69 gonadotropin releasing hormone receptor Rattus norvegicus 153-167 2362633-1 1990 Intense proteinuria in rats bearing a functioning pituitary tumor MtT SA5 was considered to be evoked by overproduction of albumin due to elevated serum growth hormone (GH). monooxyethylene trimethylolpropane tristearate 66-69 gonadotropin releasing hormone receptor Rattus norvegicus 169-171 2602387-3 1989 The expression of both PRL and growth hormone mRNA levels was increased in the MtT/F4 tumors. monooxyethylene trimethylolpropane tristearate 79-82 gonadotropin releasing hormone receptor Rattus norvegicus 31-45 2602387-6 1989 E2 also stimulated both growth hormone and PRL mRNA expression in the MtT/F4 transplantable tumor. monooxyethylene trimethylolpropane tristearate 70-73 gonadotropin releasing hormone receptor Rattus norvegicus 24-38 2917354-5 1989 There was a significant decrease in PRL mRNA and an increase in GH mRNA expression in cultured MtT/W15 tumor cells by immunocytochemistry and in situ hybridization analyses. monooxyethylene trimethylolpropane tristearate 95-98 gonadotropin releasing hormone receptor Rattus norvegicus 64-66 2917354-6 1989 The percentage of cells producing both PRL and GH or mammosomatotropic cells analyzed by two different techniques declined after one week in culture in normal pituitary cells and in cultured MtT/W15 tumor cells after E17 beta treatment. monooxyethylene trimethylolpropane tristearate 191-194 gonadotropin releasing hormone receptor Rattus norvegicus 47-49 194684-0 1977 Effect of somatostatin on growth hormone release by MtT-F4 rat pituitary tumor in vitro. monooxyethylene trimethylolpropane tristearate 52-55 gonadotropin releasing hormone receptor Rattus norvegicus 26-40 6540621-2 1984 MtT SA5 tumor produces prolactin (PRL), growth hormone, and adrenocorticotropic hormone, and MtT SA6 tumor secretes PRL and growth hormone. monooxyethylene trimethylolpropane tristearate 0-3 gonadotropin releasing hormone receptor Rattus norvegicus 40-54 7017214-5 1981 In the MtT.W10 tumor, both immunoreactive prolactin and growth hormone were observed in the same cell and in separate cell types. monooxyethylene trimethylolpropane tristearate 7-10 gonadotropin releasing hormone receptor Rattus norvegicus 56-70 6409174-1 1983 Inoculation of cyclic female rats with the prolactin (Prl)/growth hormone-secreting pituitary tumor, MtT.W15, resulted in a cessation of estrous cyclicity within 5--10 days. monooxyethylene trimethylolpropane tristearate 101-104 gonadotropin releasing hormone receptor Rattus norvegicus 59-73 178673-7 1976 The results suggest that growth hormone and prolactin are produced by a single cell type in the MtT/F4 tumor. monooxyethylene trimethylolpropane tristearate 96-99 gonadotropin releasing hormone receptor Rattus norvegicus 25-39