PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31907279-3	2020	Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter.	Poly C	138-145	D-box binding PAR bZIP transcription factor	Homo sapiens	112-115	
31907279-4	2020	Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K.	Poly C	96-103	D-box binding PAR bZIP transcription factor	Homo sapiens	209-212	
31160492-0	2019	The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation.	Poly C	4-11	D-box binding PAR bZIP transcription factor	Homo sapiens	57-79	
31160492-0	2019	The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation.	Poly C	4-11	D-box binding PAR bZIP transcription factor	Homo sapiens	86-89	
31160492-3	2019	Here, we demonstrated that the poly(C) motif within the Dbp proximal promoter, in addition to an E-box element, provoked transcriptional activation.	Poly C	31-38	D-box binding PAR bZIP transcription factor	Homo sapiens	56-59	
31160492-4	2019	Furthermore, we generated a cell line with poly(C) deleted to demonstrate the endogenous effect of the poly(C) motif within the Dbp promoter.	Poly C	103-110	D-box binding PAR bZIP transcription factor	Homo sapiens	128-131	
31160492-6	2019	Next, assay for transposase-accessible chromatin (ATAC)-quantitative PCR (qPCR) showed that the poly(C) motif induced greater chromatin accessibility within the region of the Dbp promoter.	Poly C	96-103	D-box binding PAR bZIP transcription factor	Homo sapiens	175-178	
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-105	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71	
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-105	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208	
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-105	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208	
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-106	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71	
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-106	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208	
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-106	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208