PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18941247-3 2008 Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I). Poly C 13-31 DExD/H-box helicase 58 Homo sapiens 268-298 22198151-6 2012 Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells. Poly C 60-68 DExD/H-box helicase 58 Homo sapiens 133-138 22198151-8 2012 These results suggest that RIG-I/MDA-5, but not TLR3, signaling triggers poly I:C-induced rapid apoptosis of human CD34(+) cells, which will provide an insight into the mechanisms of dsRNA virus-mediated hematopoietic disorders. Poly C 73-81 DExD/H-box helicase 58 Homo sapiens 27-32 19234166-9 2009 Our studies also show that the ability of RIG-I to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its interaction with HSP90 is inhibited. Poly C 92-110 DExD/H-box helicase 58 Homo sapiens 42-47 18941247-3 2008 Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I). Poly C 13-31 DExD/H-box helicase 58 Homo sapiens 300-305 18471880-5 2008 Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production. Poly C 51-73 DExD/H-box helicase 58 Homo sapiens 5-10 26283481-0 2015 Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8. Poly C 54-72 DExD/H-box helicase 58 Homo sapiens 19-24