PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-45 interferon beta 1, fibroblast Mus musculus 267-275 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-44 interferon beta 1, fibroblast Mus musculus 267-275 26659307-6 2015 RESULTS: Polyinosinic:polycytidylic acid transfection led to elevated expression of the genes encoding IFNalpha, IFNbeta, CXCL10, Fas, viral receptors, and IFN-inducible antiviral effectors in MIN6 cells. Poly C 22-40 interferon beta 1, fibroblast Mus musculus 113-120 28411188-3 2017 RKIP deficiency or silencing significantly decreases polyinosinic:polycytidylic acid [Poly(I:C)]-induced IFN-beta, IL-6, and TNF-alpha production without affecting the counterpart induced by LPS or CpG. Poly C 66-84 interferon beta 1, fibroblast Mus musculus 105-113 2826599-13 1988 These results show that the observed conditioned enhancement of NK activity in conditioned animals is not caused by any nociceptive properties of the CS itself and is dependent on the IFN-beta produced after Poly I:C injection in the conditioned paradigm. Poly C 208-216 interferon beta 1, fibroblast Mus musculus 184-192 26646717-5 2015 HBD3 exacerbated the production of type I Interferon-beta in response to the viral ligand mimic polyinosinic:polycytidylic acid (polyI:C) in both human and mouse primary cells, although production of the chemokine CXCL10 was suppressed. Poly C 109-127 interferon beta 1, fibroblast Mus musculus 42-57 24113362-6 2014 The expression of interferon (IFN)-beta was induced by the addition of polyinosinic:polycytidylic acid [poly(I:C)] in TS cells, but not ES cells, although TLR-3 was expressed at the same level in both cell types. Poly C 84-102 interferon beta 1, fibroblast Mus musculus 18-39 21968540-0 2012 Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice. Poly C 80-88 interferon beta 1, fibroblast Mus musculus 0-15 21968540-6 2012 These results suggest that anti-virus cytokine IFN-beta in response to poly I:C might be maintained despite severe stressful exercise. Poly C 71-79 interferon beta 1, fibroblast Mus musculus 47-55 21479492-7 2008 An anti-IFN-beta neu-tralizing antibody partially inhibited poly(I):poly(C)-induced RIG-I expression. Poly C 68-75 interferon beta 1, fibroblast Mus musculus 8-16 21106850-3 2011 Blockade of Akt by a dominant-negative mutant or by short interfering RNA decreased IRF3 activation and IFN-beta expression induced by polyinosinic:polycytidylic acid [poly(I:C)], LPS, TRIF, and TBK1. Poly C 148-166 interferon beta 1, fibroblast Mus musculus 104-112 21540291-5 2011 Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta). Poly C 68-86 interferon beta 1, fibroblast Mus musculus 270-278 21479492-8 2008 These results indicate that RIG-I production is induced by poly(I):poly(C)-provoked IFN-beta in mouse osteoblastic E1 cells. Poly C 67-74 interferon beta 1, fibroblast Mus musculus 84-92 17390082-4 2007 The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Poly C 158-165 interferon beta 1, fibroblast Mus musculus 20-28 18191426-2 2008 Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense. Poly C 61-83 interferon beta 1, fibroblast Mus musculus 116-138 18191426-2 2008 Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense. Poly C 85-93 interferon beta 1, fibroblast Mus musculus 116-138 18191426-4 2008 To determine whether poly I:C-induced IFN-beta production is responsible for reduced spontaneous physical activity, we measured poly I:C-induced changes in voluntary wheel-running activity in mice. Poly C 21-29 interferon beta 1, fibroblast Mus musculus 38-46 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 61-79 interferon beta 1, fibroblast Mus musculus 176-184 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 89-96 interferon beta 1, fibroblast Mus musculus 176-184 17390082-3 2007 Poly(I):poly(C) markedly increased IFN-beta mRNA level in a dose-dependent manner. Poly C 8-15 interferon beta 1, fibroblast Mus musculus 35-43 17390082-4 2007 The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Poly C 90-97 interferon beta 1, fibroblast Mus musculus 20-28 17390082-6 2007 An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation. Poly C 67-74 interferon beta 1, fibroblast Mus musculus 8-16 7969187-3 1994 GM-CSF and IFN-beta genes were expressed in response to PMA/A23187, poly(I):poly(C), IL-1 alpha, forskolin, or LPS stimulation in differentiated P19 cells, whereas IL-3 and IL-4 genes were not expressed. Poly C 76-83 interferon beta 1, fibroblast Mus musculus 11-19