PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17596538-8 2007 In contrast, the I134T mutant responds to a known GHSR inverse agonist, [D-Arg(1), D-Phe(5), D-Trp(7,9), Leu(11)]-substance P (SP-analog), albeit with reduced efficacy. Leucine 105-108 growth hormone secretagogue receptor Homo sapiens 50-54 21036226-4 2010 [D-Arg(1), D-Phe(5), D-Trp(7,9), Leu(11)]-substance P was the first inverse agonist to be identified for the ghrelin receptor, and this peptide has been used as a starting point for identification of the structural requirements for inverse agonist properties in the ligand. Leucine 33-36 growth hormone secretagogue receptor Homo sapiens 109-125 17428235-7 2007 Importantly, the GHSR inverse agonist [D-Arg(1) D-Phe(5) D-Trp(7,9) Leu(11)]-Substance P (SP-analogue) blocked the adenosine stimulated calcium release, demonstrating that GHSR is involved. Leucine 68-71 growth hormone secretagogue receptor Homo sapiens 17-21