PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29732121-4 2018 We previously established a bump-&-hole system for the BET bromodomains, pairing a leucine/alanine mutation with an ethyl-derived analogue of an established benzodiazepine scaffold. Leucine 87-94 delta/notch like EGF repeat containing Homo sapiens 59-62 25323695-5 2014 We developed an ethyl derivative of an existing small-molecule inhibitor, I-BET/JQ1, and showed that it binds leucine/alanine mutant bromodomains with nanomolar affinity and achieves up to 540-fold selectivity relative to wild-type bromodomains. Leucine 110-117 delta/notch like EGF repeat containing Homo sapiens 76-79