PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26132046-0	2015	Structure-Based Assignment of Ile, Leu, and Val Methyl Groups in the Active and Inactive Forms of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 2.	Leucine	35-38	mitogen-activated protein kinase 1	Homo sapiens	135-174	
32610117-0	2020	The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation.	Leucine	4-11	mitogen-activated protein kinase 1	Homo sapiens	66-69	
21289294-6	2011	The results also suggest that leucine-induced stimulation of mTORC1 signaling occurs through a mechanism distinct from TSC2 and the Akt and ERK signaling pathways.	Leucine	30-37	mitogen-activated protein kinase 1	Homo sapiens	140-143	
24646332-8	2014	Leucine is also shown to increase the magnitude of insulin-mediated extracellularly regulated kinase (ERK) phosphorylation; however, differently from AKT and GSK3beta, ERK shows a transient behavior, with an early peak response, followed by a return to the baseline condition.	Leucine	0-7	mitogen-activated protein kinase 1	Homo sapiens	102-105	
24646332-8	2014	Leucine is also shown to increase the magnitude of insulin-mediated extracellularly regulated kinase (ERK) phosphorylation; however, differently from AKT and GSK3beta, ERK shows a transient behavior, with an early peak response, followed by a return to the baseline condition.	Leucine	0-7	mitogen-activated protein kinase 1	Homo sapiens	168-171	
24550275-3	2014	NMR data for the methyl side chains on Ile, Leu, and Val residues showed changes in conformational exchange dynamics in the microsecond-to-millisecond time regime between the different activity states of ERK2.	Leucine	44-47	mitogen-activated protein kinase 1	Homo sapiens	204-208	
23178880-2	2012	Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1.	Leucine	76-79	mitogen-activated protein kinase 1	Homo sapiens	40-44	
23178880-2	2012	Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1.	Leucine	76-79	mitogen-activated protein kinase 1	Homo sapiens	96-100	
22009140-0	2012	L-Leucine induces growth arrest and persistent ERK activation in glioma cells.	Leucine	0-9	mitogen-activated protein kinase 1	Homo sapiens	47-50	
25248562-6	2015	Moreover, the Erk-mediated metastatic action was abolished by the mutation of leucine into arginine within the heptad leucine repeat region, which affects protein-protein interactions.	Leucine	78-85	mitogen-activated protein kinase 1	Homo sapiens	14-17	
24253382-7	2014	The PPME1 gene knockdown also led to a consistent decrease in PP2A demethylation at leucine 309, which was correlated with the downregulation of cellular Erk and AKT phosphorylation.	Leucine	84-91	mitogen-activated protein kinase 1	Homo sapiens	154-157	
16897753-0	2006	Leucine stimulates procollagen alpha1(I) translation on hepatic stellate cells through ERK and PI3K/Akt/mTOR activation.	Leucine	0-7	mitogen-activated protein kinase 1	Homo sapiens	87-90	
16897753-5	2006	Leucine also induced mTOR, ERK, and Akt phosphorylation in HSC, without affecting p38 and JNK activation.	Leucine	0-7	mitogen-activated protein kinase 1	Homo sapiens	27-30	
21494553-7	2011	The computer-generated model was used to guide mutagenesis experiments, which support the notion that Leu-11 and possibly Ile-13 and Ile-14 of Ets-1 1-138 (Ets) make contributions through binding to the hydrophobic groove of the ERK2 D-recruiting site (DRS).	Leucine	102-105	mitogen-activated protein kinase 1	Homo sapiens	229-233	
17707924-6	2007	However, preincubation with glutathione prevented ERK, Akt and mTOR phosphorylation caused by treatment with leucine.	Leucine	109-116	mitogen-activated protein kinase 1	Homo sapiens	50-53	
17194451-5	2007	The covalent bond motif in the ERK2/FR148083 complex assures that the inhibitor has high activity for ERK2 and no activity for other MAPKs such as JNK1 and p38MAPKalpha/beta/gamma/delta which have leucine residues at the site corresponding to Cys166 in ERK2.	Leucine	197-204	mitogen-activated protein kinase 1	Homo sapiens	31-35	
17194451-5	2007	The covalent bond motif in the ERK2/FR148083 complex assures that the inhibitor has high activity for ERK2 and no activity for other MAPKs such as JNK1 and p38MAPKalpha/beta/gamma/delta which have leucine residues at the site corresponding to Cys166 in ERK2.	Leucine	197-204	mitogen-activated protein kinase 1	Homo sapiens	102-106	
17194451-5	2007	The covalent bond motif in the ERK2/FR148083 complex assures that the inhibitor has high activity for ERK2 and no activity for other MAPKs such as JNK1 and p38MAPKalpha/beta/gamma/delta which have leucine residues at the site corresponding to Cys166 in ERK2.	Leucine	197-204	mitogen-activated protein kinase 1	Homo sapiens	102-106