PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Leucine	154-157	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	57-61	
8144631-11	1994	Comparisons between peptide sequences suggest that the N-terminal SH2 domain of SH-PTP2 binds with highest affinity to phosphotyrosine (pY) followed by a beta-branched residue (Val, Ile, Thr) at pY+1 and a hydrophobic residue (Val, Leu, Ile) at pY+3 positions.	Leucine	232-235	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	80-87	
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Leucine	154-157	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	69-73	
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Leucine	162-165	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	57-61	
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Leucine	162-165	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	69-73	
23129808-3	2013	Here we show that the protein tyrosine phosphatase SHP-2 is required for leucine-induced activation of S6K1 in skeletal myoblasts.	Leucine	73-80	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	51-56	
23129808-4	2013	In response to leucine, S6K1 activation is inhibited in myoblasts either lacking SHP-2 expression or overexpressing a catalytically inactive mutant of SHP-2.	Leucine	15-22	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	81-86	
23129808-4	2013	In response to leucine, S6K1 activation is inhibited in myoblasts either lacking SHP-2 expression or overexpressing a catalytically inactive mutant of SHP-2.	Leucine	15-22	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	151-156	
23129808-5	2013	Activation of S6K1 by leucine requires the mobilization of intracellular calcium (Ca(2+)), which we show is mediated by SHP-2 in an inositol-1,4,5-trisphosphate-dependent manner.	Leucine	22-29	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	120-125