PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Leucine	78-81	membrane metalloendopeptidase	Homo sapiens	9-19	
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Leucine	87-90	membrane metalloendopeptidase	Homo sapiens	9-19	
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Leucine	87-90	membrane metalloendopeptidase	Homo sapiens	9-19	
9218437-5	1997	The predominant amino acids detected by protein sequence analysis following cleavage of insoluble elastin with HME, MME, and 92-kDa gelatinase were Leu, Ile, Ala, Gly, and Val.	Leucine	148-151	membrane metalloendopeptidase	Homo sapiens	116-119	
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Leucine	199-202	membrane metalloendopeptidase	Homo sapiens	398-401	
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Leucine	199-202	membrane metalloendopeptidase	Homo sapiens	403-430	
15134871-5	2004	NEP cleaved substance P (SP) at Gln(6)-Phe(7), Phe(7)[see text]-Phe(8), and Gly(9)-Leu(10) and neurotensin (NT) at Pro(10)-Tyr(11) and Tyr(11)-Ile(12).	Leucine	83-86	membrane metalloendopeptidase	Homo sapiens	0-3	
9218437-6	1997	HME and MME were similar in their substrate specificity and showed a stronger preference for Leu/Ile than did the 92-kDa enzyme.	Leucine	93-96	membrane metalloendopeptidase	Homo sapiens	8-11	
3909153-9	1985	Kinetic studies with pure human renal NEP showed that the chemotactic peptide fMet-Leu-Phe was one of the best biologically active substrates (Km, 59 X 10(-6) M; kcat, 3654 min-1).	Leucine	83-86	membrane metalloendopeptidase	Homo sapiens	38-41	
1935939-5	1991	By using inhibitors of distinct classes of endoproteases, this particular fMet-Leu-Phe degradation was attributed exclusively to an exoplasmic metalloendoprotease that matches the ubiquitous neutral endopeptidase (NEP).	Leucine	79-82	membrane metalloendopeptidase	Homo sapiens	191-212	
1935939-5	1991	By using inhibitors of distinct classes of endoproteases, this particular fMet-Leu-Phe degradation was attributed exclusively to an exoplasmic metalloendoprotease that matches the ubiquitous neutral endopeptidase (NEP).	Leucine	79-82	membrane metalloendopeptidase	Homo sapiens	214-217	
1935939-9	1991	Based on these and previously reported results, a novel model is proposed in which the fMet-Leu-Phe-induced inflammatory stimulation of PMN involves both NEP and the fMet-Leu-Phe receptor.	Leucine	92-95	membrane metalloendopeptidase	Homo sapiens	154-157	
8587470-5	1995	Interchange between Leu and Trp abolished the inhibitory activities for ECE and NEP, but the compound remained active for ACE.	Leucine	20-23	membrane metalloendopeptidase	Homo sapiens	80-83	
2145213-2	1990	The concentration of NEP was quantified in detergent extracts of synovial tissues by the percentage hydrolysis of [3H-D-Ala]-Leu enkephalin/hr/100 mg of tissue.	Leucine	125-128	membrane metalloendopeptidase	Homo sapiens	21-24	
3288636-9	1988	First, we confirm that NEP present on the plasma membrane cleaves fMLP at the Met-Leu bond; then the dipeptide Leu-Phe is cleaved by a dipeptidase.	Leucine	82-85	membrane metalloendopeptidase	Homo sapiens	23-26	
3288636-9	1988	First, we confirm that NEP present on the plasma membrane cleaves fMLP at the Met-Leu bond; then the dipeptide Leu-Phe is cleaved by a dipeptidase.	Leucine	111-114	membrane metalloendopeptidase	Homo sapiens	23-26