PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31204932-6	2019	CONCLUSIONS: Pioglitazone can reverse the adriamycin-resistance in K562/ADR cells that is closely related to the decrease of protein expression of CYP2C8 and CYP2J2.	Doxorubicin	42-52	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	158-164	
29629756-0	2018	An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2.	Doxorubicin	23-34	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	67-73	
29200270-0	2017	Arachidonic Acid Metabolism by Human Cardiovascular CYP2J2 Is Modulated by Doxorubicin.	Doxorubicin	75-86	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	52-58	
29200270-5	2017	Using kinetic analyses, we show that AA metabolism by CYP2J2 is modulated by DOX.	Doxorubicin	77-80	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	54-60	
29200270-6	2017	We show that cytochrome P450 reductase, the redox partner of CYP2J2, metabolizes DOX to 7-deoxydoxorubicin aglycone (7-de-aDOX).	Doxorubicin	81-84	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	61-67	
29200270-11	2017	Altogether, we demonstrate that DOX and 7-de-aDOX inhibit CYP2J2-mediated AA metabolism and 7-de-aDOX binds close to the active site to alter the ratio of cardioprotective EETs.	Doxorubicin	32-35	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	58-64	
29200270-12	2017	These mechanistic studies of CYP2J2 can aid in the design of new alternative DOX derivatives.	Doxorubicin	77-80	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	29-35	
29098037-8	2017	However, the doxorubicin-induced reduction in cell viability was significantly attenuated by enhanced upregulation of CYP2J2 expression.	Doxorubicin	13-24	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	118-124	
29098037-10	2017	In conclusion, CYP2J2 serves important roles in cancer cell proliferation and resistance to the anticancer agent doxorubicin in HepG2 cells.	Doxorubicin	113-124	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	15-21	
19429816-0	2009	Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity.	Doxorubicin	53-64	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	18-24	
19429816-8	2009	However, cardiac function, assessed by measurement of fractional shortening with M-mode transthoracic echocardiography, was significantly higher in CYP2J2 Tr than WT hearts after chronic Dox treatment (WT 37 +/- 2%, CYP2J2 Tr 47 +/- 1%).	Doxorubicin	187-190	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	148-154	
19429816-12	2009	Together, these data suggest that cardiac-specific overexpression of CYP2J2 limited Dox-induced toxicity.	Doxorubicin	84-87	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	69-75