PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19307502-10 2009 MGST1 expression was associated with doxorubicin chemosensitivity. Doxorubicin 37-48 microsomal glutathione S-transferase 1 Homo sapiens 0-5 21851097-2 2011 Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer resistance against a number of cytostatic drugs, including cisplatin and doxorubicin (DOX). Doxorubicin 246-257 microsomal glutathione S-transferase 1 Homo sapiens 78-83 21851097-2 2011 Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer resistance against a number of cytostatic drugs, including cisplatin and doxorubicin (DOX). Doxorubicin 259-262 microsomal glutathione S-transferase 1 Homo sapiens 78-83 21851097-6 2011 Here we synthesized two derivatives of DOX, 2,4-dinitrobenzenesulfonyl doxorubicin (DNS-DOX) and 4-mononitrobenzenesulfonyl doxorubicin (MNS-DOX) and showed that they are substrates for MGST1 and GSTP (releasing DOX). Doxorubicin 39-42 microsomal glutathione S-transferase 1 Homo sapiens 186-191 21851097-7 2011 MGST1 overexpressing cells are resistant to DOX. Doxorubicin 44-47 microsomal glutathione S-transferase 1 Homo sapiens 0-5 21851097-10 2011 It would appear that, by controlling the reactivity of the prodrug, and thereby the DOX release rate, selective toxicity to MGST1 overexpressing cells can be achieved. Doxorubicin 84-87 microsomal glutathione S-transferase 1 Homo sapiens 124-129 24210875-3 2014 We demonstrate in this work that polyester-based hyperbranched dendritic-linear (HBDL)-based NPs carrying doxorubicin (Dox) can effectively overcome microsomal glutathione transferase 1 (MGST1)-mediated drug resistance in breast cancer cells. Doxorubicin 106-117 microsomal glutathione S-transferase 1 Homo sapiens 187-192 24210875-3 2014 We demonstrate in this work that polyester-based hyperbranched dendritic-linear (HBDL)-based NPs carrying doxorubicin (Dox) can effectively overcome microsomal glutathione transferase 1 (MGST1)-mediated drug resistance in breast cancer cells. Doxorubicin 119-122 microsomal glutathione S-transferase 1 Homo sapiens 187-192 24210875-7 2014 Moreover, we found that Dox-HBDL significantly decreased the expression of MGST1 and enhanced mitochondria-mediated apoptotic cell death compared to free Dox. Doxorubicin 24-27 microsomal glutathione S-transferase 1 Homo sapiens 75-80