PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17483339-1 2007 Doxorubicin treatment was found to augment the expression of the extracellular matrix (ECM) protein fibulin-1 in cultured human breast cancer cell lines and in MDA-MB-361 tumors grown in athymic mice. Doxorubicin 0-11 fibulin 1 Homo sapiens 100-109 17483339-2 2007 Doxorubicin was also found to augment tumor expression of the fibulin-1-binding proteins fibronectin and laminin-1. Doxorubicin 0-11 fibulin 1 Homo sapiens 62-71 17483339-3 2007 Growth of breast cancer cell lines on Matrigel, an ECM extract containing fibulin-1 and laminin-1, resulted in lower levels of doxorubicin-induced apoptosis as compared with controls. Doxorubicin 127-138 fibulin 1 Homo sapiens 74-83 17483339-5 2007 Monoclonal antibodies against fibulin-1 reversed Matrigel-dependent doxorubicin resistance. Doxorubicin 68-79 fibulin 1 Homo sapiens 30-39 17483339-6 2007 Furthermore, small interfering RNA-mediated suppression of fibulin-1 expression in breast cancer cells resulted in a 10-fold increase in doxorubicin sensitivity as compared with control cells. Doxorubicin 137-148 fibulin 1 Homo sapiens 59-68