PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21602882-2 2011 Phosphorylation of p53 at S46, an apoptosis-specific p53 posttranslational modification, is the most characterized HIPK2 function in response to lethal doses of ultraviolet (UV), ionizing radiation or different anticancer drugs, such as cisplatin, roscovitine and doxorubicin (DOX). Doxorubicin 264-275 homeodomain interacting protein kinase 2 Homo sapiens 115-120 28060750-0 2017 HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation. Doxorubicin 64-75 homeodomain interacting protein kinase 2 Homo sapiens 0-5 28060750-0 2017 HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation. Doxorubicin 64-75 homeodomain interacting protein kinase 2 Homo sapiens 84-89 28060750-6 2017 Next, we assessed cell response following UV-irradiation or treatment with doxorubicin, two well-known HIPK2 activators, by evaluating cell number and viability, p53-Ser46 phosphorylation, p21 induction, and caspase cleavage. Doxorubicin 75-86 homeodomain interacting protein kinase 2 Homo sapiens 103-108 28060750-7 2017 Interestingly, cells expressing HIPK2-T566P mutant did not respond to UV-irradiation, while behaved similarly to wt HIPK2 upon doxorubicin-treatment. Doxorubicin 127-138 homeodomain interacting protein kinase 2 Homo sapiens 32-37 28060750-8 2017 Evaluation of HIPK2-T566 phosphorylation status by a T566-phospho-specific antibody showed constitutive phosphorylation in unstressed cells, which was maintained after doxorubicin-treatment but inhibited by UV-irradiation. Doxorubicin 168-179 homeodomain interacting protein kinase 2 Homo sapiens 14-19 21602882-2 2011 Phosphorylation of p53 at S46, an apoptosis-specific p53 posttranslational modification, is the most characterized HIPK2 function in response to lethal doses of ultraviolet (UV), ionizing radiation or different anticancer drugs, such as cisplatin, roscovitine and doxorubicin (DOX). Doxorubicin 277-280 homeodomain interacting protein kinase 2 Homo sapiens 115-120 21602882-9 2011 In DOX-treated cells, we show that HIPK2 depletion interferes with DeltaNp63alpha degradation, and expression of a HIPK2-resistant DeltaNp63alpha-Delta390 mutant induces chemoresistance. Doxorubicin 3-6 homeodomain interacting protein kinase 2 Homo sapiens 35-40 21602882-9 2011 In DOX-treated cells, we show that HIPK2 depletion interferes with DeltaNp63alpha degradation, and expression of a HIPK2-resistant DeltaNp63alpha-Delta390 mutant induces chemoresistance. Doxorubicin 3-6 homeodomain interacting protein kinase 2 Homo sapiens 115-120 19828042-5 2009 RESULTS: Knockdown of HIPK2 inhibited both adriamycin-induced Ser46 phosphorylation and Lys382 acetylation in p53 protein; however, while combination of ADR and zinc restored Ser46 phosphorylation it did not recover Lys382 acetylation. Doxorubicin 43-53 homeodomain interacting protein kinase 2 Homo sapiens 22-27 20980392-7 2010 Furthermore, DNA-damage-inducing agents doxorubicin, etoposide and sodium arsenite induced ferritin H mRNA expression in HIPK2(+/+) MEF cells, whereas it was significantly impaired in HIPK2(-/-) MEF cells. Doxorubicin 40-51 homeodomain interacting protein kinase 2 Homo sapiens 121-126 20980392-7 2010 Furthermore, DNA-damage-inducing agents doxorubicin, etoposide and sodium arsenite induced ferritin H mRNA expression in HIPK2(+/+) MEF cells, whereas it was significantly impaired in HIPK2(-/-) MEF cells. Doxorubicin 40-51 homeodomain interacting protein kinase 2 Homo sapiens 184-189 18395248-8 2008 RESULTS: HIPK2 was expressed differently in sensitive versus chemoresistant cells in response to different chemotherapeutic drugs (i.e., cisplatin and adriamycin), though the p53Ser46 apoptotic pathway was not defective in chemoresistant 2008C13 cells. Doxorubicin 151-161 homeodomain interacting protein kinase 2 Homo sapiens 9-14 18395248-9 2008 Thus, 2008C13 cells were resistant to cisplatin but sensitive to adriamycin-induced apoptosis through activation of the HIPK2/p53Ser46 pathway. Doxorubicin 65-75 homeodomain interacting protein kinase 2 Homo sapiens 120-125 18395248-10 2008 HIPK2 knock-down inhibited the adriamycin-induced apoptosis in 2008C13 cells. Doxorubicin 31-41 homeodomain interacting protein kinase 2 Homo sapiens 0-5 18483253-5 2008 We present evidence that zinc supplementation to HIPK2i cells increased p53 reactivity to conformation-sensitive PAb1620 (wild-type conformation) antibody and restored p53 sequence-specific DNA binding in vivo and transcription of target genes in response to Adriamycin treatment. Doxorubicin 259-269 homeodomain interacting protein kinase 2 Homo sapiens 49-54 18093972-10 2008 The ubiquitination and degradation of HIPK2 by WSB-1 was inhibited completely via the administration of DNA damage reagents, including Adriamycin and cisplatin. Doxorubicin 135-145 homeodomain interacting protein kinase 2 Homo sapiens 38-43 11925430-9 2002 Stable expression of HIPK2 in U2OS cells enhanced the cisplatin response of sub-G(1) and G(2)/M populations, and it also increased the apoptotic response to cisplatin and adriamycin as demonstrated by fluorescence-activated cell sorter and 4",6-diamidino-2-phenylindole-staining analyses. Doxorubicin 171-181 homeodomain interacting protein kinase 2 Homo sapiens 21-26 11532197-4 2001 Overexpression of HIPK2 leads to an increase of p53 protein expression or stability, which becomes enhanced further in the presence of the DNA damaging drug doxorubicin. Doxorubicin 157-168 homeodomain interacting protein kinase 2 Homo sapiens 18-23 30217455-0 2018 4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway. Doxorubicin 87-97 homeodomain interacting protein kinase 2 Homo sapiens 141-146 30217455-7 2018 4-HBA significantly promoted the anticancer effect of ADM on apoptosis induction, as evidenced by the increased expressions of Caspase-3 and PARP cleavage, which was associated with the promotion p53 and homeodomain interacting protein kinase-2 (HIPK2) expressions in ADM-resistant breast cancer cells. Doxorubicin 54-57 homeodomain interacting protein kinase 2 Homo sapiens 204-244 30217455-7 2018 4-HBA significantly promoted the anticancer effect of ADM on apoptosis induction, as evidenced by the increased expressions of Caspase-3 and PARP cleavage, which was associated with the promotion p53 and homeodomain interacting protein kinase-2 (HIPK2) expressions in ADM-resistant breast cancer cells. Doxorubicin 54-57 homeodomain interacting protein kinase 2 Homo sapiens 246-251