PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33351694-10 2020 The interactions among circ_0002060, miR-198, and ABCB1 in DOX-resistant OS cells were confirmed by dual-luciferase reporter assay, RNA immunoprecipitation assay, or RNA pull-down assay. Doxorubicin 59-62 microRNA 198 Homo sapiens 37-44 33351694-11 2020 Results: circ_0002060 and ABCB1 were upregulated, while miR-198 was downregulated in OS tissues and DOX-resistant OS cells. Doxorubicin 100-103 microRNA 198 Homo sapiens 56-63 33351694-13 2020 Moreover, circ_0002060 enhanced DOX resistance by sponging miR-198. Doxorubicin 32-35 microRNA 198 Homo sapiens 59-66 33351694-14 2020 Besides, miR-198 decreased DOX resistance by binding to ABCB1. Doxorubicin 27-30 microRNA 198 Homo sapiens 9-16 33351694-16 2020 Conclusions: circ_0002060 promoted DOX resistance and OS progression by regulating the miR-198/ABCB1 axis, suggesting that circ_0002060 might be a promising biomarker for OS therapy. Doxorubicin 35-38 microRNA 198 Homo sapiens 87-94