PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30827825-9	2019	Apoptosis become found through DNA fragmentation assay and quantification of Caspase 3, Caspase 9, Bcl2 and Cytochrome C. Doxorubicin mediated oxidative stress and apoptosis in testicular milieu is through deregulation of Nrf2, PGC-1alpha, AHR, ARNT, PXR, SUMO-1, UCP2, UCP3, ANX A5, Caspase 3, Caspase 9, Bcl2, Cytochrome C, GR, and GPX.	Doxorubicin	122-133	caspase 9	Rattus norvegicus	88-97	
30827825-9	2019	Apoptosis become found through DNA fragmentation assay and quantification of Caspase 3, Caspase 9, Bcl2 and Cytochrome C. Doxorubicin mediated oxidative stress and apoptosis in testicular milieu is through deregulation of Nrf2, PGC-1alpha, AHR, ARNT, PXR, SUMO-1, UCP2, UCP3, ANX A5, Caspase 3, Caspase 9, Bcl2, Cytochrome C, GR, and GPX.	Doxorubicin	122-133	caspase 9	Rattus norvegicus	295-304	
26318906-10	2016	Treatment with the antioxidant and protein kinase C (PKC-beta) inhibitor hispidin decreased DOX-induced activation of caspase 9 and p66Shc alterations.	Doxorubicin	92-95	caspase 9	Rattus norvegicus	118-127	
28214865-7	2017	RESULTS: In vivo experiment, adriamycin significantly upregulated the protein expression of TGF-beta1, TRPC6, desmin and caspase-9, and decreased nephrin.	Doxorubicin	29-39	caspase 9	Rattus norvegicus	121-130	
21295102-7	2011	Pretreatment with curcumin significantly increased DOX-induced apoptosis of cardiac muscle cells through down regulation of Bcl-2, up-regulation of caspase-8 and caspase-9.	Doxorubicin	51-54	caspase 9	Rattus norvegicus	162-171	
21476075-8	2012	Western blot analysis showed that doxorubicin administration markedly increased the levels of caspase-9, 3, -8, -12, Fas, Bid and disturbed the Bcl-2 family protein balance.	Doxorubicin	34-45	caspase 9	Rattus norvegicus	94-103	
21295553-6	2011	Signal transduction studies showed that doxorubicin increased p53, JNK, p38 and NFkappaB phosphorylation; decreased the levels of phospho ERK and Akt; disturbed the Bcl-2 family protein balance; activated caspase 12, caspase 9 and caspase 3; and induced cleavage of the PARP protein.	Doxorubicin	40-51	caspase 9	Rattus norvegicus	217-226	
18321562-6	2008	The results showed that adriamycin administered to the mother rat before pregnancy subsequently induced changes in fetal kidneys involving both the mitochondrial pathway of apoptosis, with increased labeling of the proteins p53, Bax, Apaf-1 and caspase 9, and the endoplasmic reticulum pathway of apoptosis, with increased labeling of caspase 12.	Doxorubicin	24-34	caspase 9	Rattus norvegicus	245-254	
18926904-3	2008	Activation of caspase-9 and -3 was considerably lower in DOX-treated ARCM as compared with NRCM and H9c2 cardiomyoblasts.	Doxorubicin	57-60	caspase 9	Rattus norvegicus	14-30	
18926904-7	2008	Adenoviral expression of Apaf1 exacerbated the activation of caspase-9 and -3 in DOX-treated NRCM, but did not increase their activities in DOX-treated ARCM.	Doxorubicin	81-84	caspase 9	Rattus norvegicus	61-77	
16902863-8	2006	TMP was found to reduce the adriamycin-stimulated activities of caspase-3, caspase-8 and caspase-9, inhibit adriamycin-induced release of cytochrome C, and elevate the expression of Bcl-x (L).	Doxorubicin	28-38	caspase 9	Rattus norvegicus	89-98	
16343480-6	2006	Ad-COX-1/PGIS transfection was found to reduce the adriamycin-stimulated activities of caspase-3 and caspase-9, inhibit adriamycin-induced release of cytochrome c, elevate the expression of Bcl-x(L), and suppress the activation and translocation of nuclear factor-kappaB (NF-kappaB) in adriamycin-treated renal tubular cells.	Doxorubicin	51-61	caspase 9	Rattus norvegicus	101-110	
34587120-4	2021	RESULTS: DOX increased ROS formation and upregulated proteins expression of AT1R, NOX2, NOX4, caspase-3, caspase-9 and MAPK signaling including p-p38, p-JNK, p-ERK in H9c2 cells.	Doxorubicin	9-12	caspase 9	Rattus norvegicus	105-114	
35571249-5	2022	DOX enhanced the activities of caspase family members in cardiomyocytes, while NaHS attenuated DOX-enhanced caspase-3, caspase-2, and caspase-9 activities by 223.1%, 73.94%, and 52.29%, respectively.	Doxorubicin	95-98	caspase 9	Rattus norvegicus	134-143	
32705166-7	2020	As shown by hypodiploid nuclei and confirmed by western blot analysis, Doxo increased caspase 9 expression and reduced procaspase 3 levels, which induced cell death.	Doxorubicin	71-75	caspase 9	Rattus norvegicus	86-95