PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25445786-3	2015	In the present work we report the role of one of the least explored Sirtuin viz., SIRT7, under conditions of genomic stress when treated with doxorubicin.	Doxorubicin	142-153	sirtuin 7	Homo sapiens	82-87	
25445786-6	2015	SIRT7 overexpressing cells when treated with low dose of doxorubicin (0.25 microM) showed delayed onset of senescence, lesser accumulation of DNA damage marker gammaH2AX and lowered levels of growth arrest markers viz., p53 and p21 when compared to doxorubicin treated control GFP expressing cells.	Doxorubicin	57-68	sirtuin 7	Homo sapiens	0-5	
25445786-6	2015	SIRT7 overexpressing cells when treated with low dose of doxorubicin (0.25 microM) showed delayed onset of senescence, lesser accumulation of DNA damage marker gammaH2AX and lowered levels of growth arrest markers viz., p53 and p21 when compared to doxorubicin treated control GFP expressing cells.	Doxorubicin	249-260	sirtuin 7	Homo sapiens	0-5	
25445786-8	2015	When treated with higher dose of doxorubicin (>1 microM), SIRT7 conferred resistance to apoptosis by attenuating stress activated kinases (SAPK viz., p38 and JNK) and p53 response thereby shifting the cellular fate towards senescence.	Doxorubicin	33-44	sirtuin 7	Homo sapiens	61-66	
25445786-10	2015	SIRT7 mediated resistance to doxorubicin induced apoptosis and senescence was lost when p53 level was restored by nutlin treatment.	Doxorubicin	29-40	sirtuin 7	Homo sapiens	0-5	
29231244-7	2018	Meanwhile, SIRT7 depletion can increase the sensitivity of breast cancer cells to doxorubicin (DOX).	Doxorubicin	82-93	sirtuin 7	Homo sapiens	11-16	
29231244-7	2018	Meanwhile, SIRT7 depletion can increase the sensitivity of breast cancer cells to doxorubicin (DOX).	Doxorubicin	95-98	sirtuin 7	Homo sapiens	11-16	
29231244-8	2018	Xenograft model studies showed that stable silencing of SIRT7 inhibited tumor growth and enhanced tumor sensitivity to DOX.	Doxorubicin	119-122	sirtuin 7	Homo sapiens	56-61	
29231244-10	2018	Taken together, our results showed that SIRT7 plays a critical role in breast cancer cell survival, migration, and tumor growth, and increased the efficiency of DOX treatment both in vitro and in vivo.	Doxorubicin	161-164	sirtuin 7	Homo sapiens	40-45	
34797559-0	2021	SIRT7 interacts with TEK (TIE2) to promote adriamycin induced metastasis in breast cancer.	Doxorubicin	43-53	sirtuin 7	Homo sapiens	0-5	
31196136-8	2019	Depletion of SIRT7 from multiple liver cancer cell lines significantly increased doxorubicin toxicity while overexpression of SIRT7 largely abolished doxorubicin induced apoptosis.	Doxorubicin	81-92	sirtuin 7	Homo sapiens	13-18	
31196136-8	2019	Depletion of SIRT7 from multiple liver cancer cell lines significantly increased doxorubicin toxicity while overexpression of SIRT7 largely abolished doxorubicin induced apoptosis.	Doxorubicin	150-161	sirtuin 7	Homo sapiens	126-131