PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35574363-10 2022 Key Findings: PRR and RAC1 expressions increased in DOX-induced HF. Doxorubicin 52-55 Rac family small GTPase 1 Rattus norvegicus 22-26 34459233-0 2021 Exosomal Micro-RNA-96 Derived From Bone Marrow Mesenchymal Stem Cells Inhibits Doxorubicin-Induced Myocardial Toxicity by Inhibiting the Rac1/Nuclear Factor-kappaB Signaling Pathway. Doxorubicin 79-90 Rac family small GTPase 1 Rattus norvegicus 137-141 34459233-11 2021 miR-96 was downregulated, Rac1 was upregulated and the nuclear factor-kappaB signaling pathway was activated in doxorubicin-induced cell and animal models. Doxorubicin 112-123 Rac family small GTPase 1 Rattus norvegicus 26-30 34459233-16 2021 Rac1 inhibition could downregulate the expression of the nuclear factor-kappaB signaling and further reverse the promotion of miR-96 knockdown on doxorubicin-induced myocardial toxicity. Doxorubicin 146-157 Rac family small GTPase 1 Rattus norvegicus 0-4 23012366-6 2012 Both the lipid-lowering drug lovastatin and the Rac1-specific inhibitor NSC23766 attenuated doxorubicin- and etoposide-stimulated H2AX phosphorylation, induction of DNA strand breaks, and topo II-DNA complex formation. Doxorubicin 92-103 Rac family small GTPase 1 Rattus norvegicus 48-52 34047412-0 2021 Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-kappaB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin. Doxorubicin 100-111 Rac family small GTPase 1 Rattus norvegicus 38-42 23012366-12 2012 Pharmacological inhibition of Rac1 signaling counteracts doxorubicin- and etoposide-stimulated DDR by disabling the formation of the topo II-DNA cleavable complex. Doxorubicin 57-68 Rac family small GTPase 1 Rattus norvegicus 30-34