PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17620346-1 2007 In rats, it has been reported that rofecoxib, a cyclooxygenase-2 (COX-2) inhibitor, reacts with the aldehyde group of allysine in elastin to give a condensation covalent adduct, thereby preventing the formation of cross-linkages in the elastin and causing degradation of the elastic fibers in aortas in vivo. allysine 118-126 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 48-64 17620346-1 2007 In rats, it has been reported that rofecoxib, a cyclooxygenase-2 (COX-2) inhibitor, reacts with the aldehyde group of allysine in elastin to give a condensation covalent adduct, thereby preventing the formation of cross-linkages in the elastin and causing degradation of the elastic fibers in aortas in vivo. allysine 118-126 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 66-71