PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11294244-5 2001 The BK channel was inhibited reversibly by external tetraethylammonium (TEA) ions, charybdotoxin, and quinine and was resistant to block by 4-aminopyridine and apamin. Charybdotoxin 83-96 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 4-14 12558995-4 2003 The patch-clamp recording found that martentoxin at the applied dose of 100 nm could strongly block large-conductance Ca2+-activated K+ (BKCa) currents in adrenal medulla chromaffin cells, and BKCa currents blocked by martentoxin could be fully recovered within 30 seconds after washing, which is at least 10 times faster than recovery after charybdotoxin. Charybdotoxin 342-355 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 193-197 21557879-4 2012 We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX). Charybdotoxin 238-251 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 217-221 21996476-1 2011 Recently, we have reported electropharmacological properties of a charybdotoxin (ChTx)- and ATP-insensitive-iberiotoxin (IbTx)-sensitive large conductance Ca+2-activated potassium (BKCa) channel in almost purified brain mitochondrial inner membrane vesicles. Charybdotoxin 66-79 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 181-185 21996476-1 2011 Recently, we have reported electropharmacological properties of a charybdotoxin (ChTx)- and ATP-insensitive-iberiotoxin (IbTx)-sensitive large conductance Ca+2-activated potassium (BKCa) channel in almost purified brain mitochondrial inner membrane vesicles. Charybdotoxin 81-85 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 181-185 21356332-4 2011 Blockade of MaxiK channels with charybdotoxin (100 nM) in both older (P16-P18) and younger (P2-P3) animals resulted in no significant change in AP activity, but increased nerve conduction speed in the older animals. Charybdotoxin 32-45 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 12-17 16151435-5 2005 This increased BKCa current activity was abolished by charybdotoxin (100 nM) and iberiotoxin (100 nM). Charybdotoxin 54-67 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 15-19 15680257-4 2005 Charybdotoxin, a blocker of large-conductance Ca(2+)-activated K+ (BK(Ca)) channels, also augmented ischemic injury, whereas AM 92016, a blocker of delayed rectifier K+ channels, and dequalinium, a blocker of small-conductance Ca(2+)-activated K+ channels, had no significant effect. Charybdotoxin 0-13 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 67-73 14691049-9 2004 Charybdotoxin (ChTX), which blocks large-conductance calcium-activated potassium channels (BK(Ca)) and intermediate-conductance calcium-activated potassium channels (IK(Ca)), plus apamin, which blocks small-conductance calcium-activated potassium channels (SK(Ca)), but not iberiotoxin, which only blocks BK(Ca), attenuated endothelium-dependent relaxation of aortae from daidzein or 17beta-oestradiol-treated rats. Charybdotoxin 0-13 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 91-97 14691049-9 2004 Charybdotoxin (ChTX), which blocks large-conductance calcium-activated potassium channels (BK(Ca)) and intermediate-conductance calcium-activated potassium channels (IK(Ca)), plus apamin, which blocks small-conductance calcium-activated potassium channels (SK(Ca)), but not iberiotoxin, which only blocks BK(Ca), attenuated endothelium-dependent relaxation of aortae from daidzein or 17beta-oestradiol-treated rats. Charybdotoxin 15-19 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 91-97 12842920-5 2003 Blockade of calcium-sensitive voltage-gated K+ channels (BKCa) with charybdotoxin or iberiotoxin inhibited 89% and 82% of the current, respectively. Charybdotoxin 68-81 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 57-61 9146898-2 1997 In the rat hepatic artery, the acetylcholine-induced relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF) is abolished by a combination of apamin and charybdotoxin, inhibitors of small (SKCa) and large (BKCa) conductance calcium-sensitive potassium (K)-channels, respectively, but not by each toxin alone. Charybdotoxin 170-183 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 223-227 10612692-5 2000 Charybdotoxin as well as paxilline, well known blockers of MaxiK channels, were able to reduce current through MaxiK channels in our cell preparation. Charybdotoxin 0-13 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 59-64 10612692-5 2000 Charybdotoxin as well as paxilline, well known blockers of MaxiK channels, were able to reduce current through MaxiK channels in our cell preparation. Charybdotoxin 0-13 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 111-116 2110977-5 1990 BRL 34915 and P 1060 specifically increase the open-state probability of the Ca+(+)-activated K+ (maxi-K+) channel, and these actions are blocked by glyburide and also by charybdotoxin. Charybdotoxin 171-184 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 98-114 28000721-7 2016 BDL significantly promoted the charybdotoxin sensitive MaxiK current and KATP current in isolated aortic smooth muscle cells. Charybdotoxin 31-44 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 55-60 28018918-7 2016 The relaxation response of colonic SM strips to stretch was attenuated by charybdotoxin (ChTX), a nonspecific BKCa blocker (P < 0.05). Charybdotoxin 74-87 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 110-114 28018918-9 2016 Still, ChTX and iberiotoxin (IbTX, a specific BKCa blocker) attenuated the relaxation of the colonic muscle strips enduring stretch (P < 0.05). Charybdotoxin 7-11 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 46-50 25128173-6 2014 In contrast, when small-conductance calcium-activated potassium (KCa) channels and intermediate- and large-conductance KCa (I/BKCa) are inhibited with apamin and charybdotoxin, NO is able to compensate for ACh-induced relaxation in control but not in diabetic vessels. Charybdotoxin 162-175 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 126-130