PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33982799-0 2021 NOXA-mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin-treated human acute myeloid leukemia cells. Daunorubicin 65-77 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 0-4 33982799-3 2021 DNR-induced apoptosis in U937 cells accompanied by downregulation of MCL1 and BCL2L1, upregulation of Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA), and mitochondrial depolarization. Daunorubicin 0-3 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 153-157 33982799-11 2021 Collectively, these results indicate that the upregulation of NOXA expression through the NOX4-ROS-p38 MAPK-GSK3beta-CREB axis results in the degradation of MCL1 and BCL2L1 in DNR-treated U937 and HL-60 cells. Daunorubicin 176-179 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 62-66