PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11311056-5 2001 Daunorubicin and doxorubicin, two widely used antineoplastic agents in tumor therapy, were covalently linked to NPY via two spacers that differ in stability: an acid-sensitive hydrazone bond at the 13-keto position of daunorubicin and a stable amide bond at the 3"-amino position of daunorubicin and doxorubicin. Daunorubicin 0-12 neuropeptide Y Homo sapiens 112-115 11311056-5 2001 Daunorubicin and doxorubicin, two widely used antineoplastic agents in tumor therapy, were covalently linked to NPY via two spacers that differ in stability: an acid-sensitive hydrazone bond at the 13-keto position of daunorubicin and a stable amide bond at the 3"-amino position of daunorubicin and doxorubicin. Daunorubicin 218-230 neuropeptide Y Homo sapiens 112-115 11311056-5 2001 Daunorubicin and doxorubicin, two widely used antineoplastic agents in tumor therapy, were covalently linked to NPY via two spacers that differ in stability: an acid-sensitive hydrazone bond at the 13-keto position of daunorubicin and a stable amide bond at the 3"-amino position of daunorubicin and doxorubicin. Daunorubicin 283-295 neuropeptide Y Homo sapiens 112-115 11311056-10 2001 We found evidence that the active conjugate [C(15)]-NPY-Dauno-HYD releases daunorubicin, which is localized close to the nucleus, whereas the inactive conjugate [C(15)]-NPY-Dauno-MBS is distributed distantly from the nucleus and does not seem to release the drug within the cell. Daunorubicin 75-87 neuropeptide Y Homo sapiens 52-55