PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16112192-4 2006 Therefore, the present study was performed to evaluate whether stem cell factor-antibody (anti-SCF) can enhance the efficacy of the two main chemotherapeutic drugs used in AML therapy: cytarabine and daunorubicin at low doses in human-resistant CD34+ AML cells, in an attempt to identify a novel effective regimen with tolerable side-effects for elderly AML patients. Daunorubicin 200-212 KIT ligand Homo sapiens 95-98 16112192-6 2006 Anti-SCF has significantly enhanced the low dose cytarabine- and daunorubicin-induced apoptosis+necrosis in KG1a CD34+ AML cells from 12.0+/-1.7 to 40.9+/-5.9% and from 16.3+/-0.9 to 48.9+/-1.0%, respectively, p<0.01. Daunorubicin 65-77 KIT ligand Homo sapiens 5-8 16112192-7 2006 It has also exerted its significant enhancement activity on the low dose cytarabine- and daunorubicin-induced apoptosis+necrosis in KG1a CD34+ AML cells in the presence of SCF, p<0.05. Daunorubicin 89-101 KIT ligand Homo sapiens 172-175 16112192-8 2006 Anti-SCF has significantly enhanced the low dose cytarabine- and daunorubicin-induced bcl-2 reduction in KG1a CD34+ AML cells from 26.7+/-0.6 to 64.6+/-1.0% and from 59.8+/-3.1 to 80.1+/-7.9%, respectively, p<0.01. Daunorubicin 65-77 KIT ligand Homo sapiens 5-8 16112192-10 2006 Anti-SCF has also significantly enhanced the low dose cytarabine- and daunorubicin-induced bcl-2 reduction in KG1a CD34+ AML cells in the presence of SCF, p<0.05. Daunorubicin 70-82 KIT ligand Homo sapiens 5-8 16112192-10 2006 Anti-SCF has also significantly enhanced the low dose cytarabine- and daunorubicin-induced bcl-2 reduction in KG1a CD34+ AML cells in the presence of SCF, p<0.05. Daunorubicin 70-82 KIT ligand Homo sapiens 150-153