PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15626738-6 2005 Overexpression of Bcl-x(L) was identified as the critical mediator of drug resistance and recapitulates the PTK inhibitor and daunorubicin-resistant phenotype in FLT3-ITD cells. Daunorubicin 126-138 BCL2 like 1 Homo sapiens 18-26 11801602-12 2002 Furthermore, doses of D-e-C(6) ceramide that induce the alternative splicing of both caspase 9 and Bcl-x-sensitized A549 cells to daunorubicin. Daunorubicin 130-142 BCL2 like 1 Homo sapiens 99-104 33982799-0 2021 NOXA-mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin-treated human acute myeloid leukemia cells. Daunorubicin 65-77 BCL2 like 1 Homo sapiens 38-44 33982799-3 2021 DNR-induced apoptosis in U937 cells accompanied by downregulation of MCL1 and BCL2L1, upregulation of Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA), and mitochondrial depolarization. Daunorubicin 0-3 BCL2 like 1 Homo sapiens 78-84 33982799-8 2021 Restoration of MCL1 or BCL2L1 expression alleviated DNR-induced mitochondrial depolarization and cell death. Daunorubicin 52-55 BCL2 like 1 Homo sapiens 23-29 33982799-11 2021 Collectively, these results indicate that the upregulation of NOXA expression through the NOX4-ROS-p38 MAPK-GSK3beta-CREB axis results in the degradation of MCL1 and BCL2L1 in DNR-treated U937 and HL-60 cells. Daunorubicin 176-179 BCL2 like 1 Homo sapiens 166-172 30361682-6 2018 Furthermore, combined inhibition of Bcl-2/Bcl-XL and Mcl-1 could revert BMSC-mediated resistance against cytarabine + daunorubicin. Daunorubicin 118-130 BCL2 like 1 Homo sapiens 42-48