PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33494481-7	2021	In this review, we evaluated the production process of poly-gamma-glutamic acid (gamma-PGA)-rich chungkookjang fermented with specific Bacillus species and their effects on memory function through the modulation of brain insulin resistance, neuroinflammation, and the gut-microbiome-brain axis.	poly(gamma-glutamic acid)	81-90	insulin	Homo sapiens	221-228	
3293085-1	1988	Polyglycine, polyalanine, polyleucine, poly-alpha-glutamic acid, poly-gamma-glutamic acid and poly-alpha-lysine were complexed with insulin under non denaturating conditions.	poly(gamma-glutamic acid)	65-89	insulin	Homo sapiens	132-139	
33494481-15	2021	This review suggests that the intake of chungkookjang (20-30 g/day) rich in gamma-PGA acts as a synbiotic in humans and promotes memory function by suppressing brain insulin resistance and neuroinflammation and by modulating the gut-microbiome-brain axis.	poly(gamma-glutamic acid)	76-85	insulin	Homo sapiens	166-173	
27210795-1	2016	To enhance the glucose sensitivity and self-regulated release of insulin, biobased capsules with glucose-responsive and competitive properties were fabricated based on poly(gamma-glutamic acid) (gamma-PGA) and chitosan oligosaccharide (CS) polyelectrolytes.	poly(gamma-glutamic acid)	168-193	insulin	Homo sapiens	65-72	
26066036-8	2016	Natural polymers, such as chitosan and its derivates, alginate derivatives, gamma-PGA-based materials and starch-based nanoparticles have been exploited for oral insulin delivery; synthetic polymers, such as PLGA, PLA, PCL and PEA have also been developed for oral administration of insulin.	poly(gamma-glutamic acid)	76-85	insulin	Homo sapiens	162-169	
22236133-13	2012	Our recent study described a pH-responsive NP system composed of chitosan (CS) and poly(gamma-glutamic acid) for oral delivery of insulin.	poly(gamma-glutamic acid)	83-107	insulin	Homo sapiens	130-137	
26541299-2	2015	We herein developed a novel self-assembled polyelectrolyte complex nanoparticles by coating insulin-loaded dodecylamine-graft-gamma-polyglutamic acid micelles with trimethyl chitosan (TMC).	poly(gamma-glutamic acid)	126-149	insulin	Homo sapiens	92-99	
18517235-2	2008	Nanoparticles (NPs) self-assembled by the synthesized TMC and poly(gamma-glutamic acid) (gamma-PGA, TMC/gamma-PGA NPs) were prepared for oral delivery of insulin.	poly(gamma-glutamic acid)	89-98	insulin	Homo sapiens	154-161	
18517235-6	2008	At pH 7.4, TMC/gamma-PGA NPs were significantly swelled and a sustained release profile of insulin was observed.	poly(gamma-glutamic acid)	15-24	insulin	Homo sapiens	91-98	
18517235-7	2008	Confocal microscopy confirmed that TMC40/gamma-PGA NPs opened the tight junctions of Caco-2 cells to allow the transport of insulin along the paracellular pathway.	poly(gamma-glutamic acid)	41-50	insulin	Homo sapiens	124-131	
18517235-8	2008	Transepithelial-electrical-resistance measurements and transport studies implied that CS/gamma-PGA NPs can be effective as an insulin carrier only in a limited area of the intestinal lumen where the pH values are close to the p K a of CS.	poly(gamma-glutamic acid)	89-98	insulin	Homo sapiens	126-133	
18517235-9	2008	In contrast, TMC40/gamma-PGA NPs may be a suitable carrier for transmucosal delivery of insulin within the entire intestinal tract.	poly(gamma-glutamic acid)	19-28	insulin	Homo sapiens	88-95	
18517235-3	2008	The loading efficiency and loading content of insulin in TMC/gamma-PGA NPs were 73.8 +/- 2.9% and 23.5 +/- 2.1%, respectively.	poly(gamma-glutamic acid)	61-70	insulin	Homo sapiens	46-53	
18517235-4	2008	TMC/gamma-PGA NPs had superior stability in a broader pH range to CS/gamma-PGA NPs; the in vitro release profiles of insulin from both test NPs were significantly affected by their stability at distinct pH environments.	poly(gamma-glutamic acid)	4-13	insulin	Homo sapiens	117-124	
18517235-5	2008	At pH 7.0, CS/gamma-PGA NPs became disintegrated, resulting in a rapid release of insulin, which failed to provide an adequate retention of loaded insulin, while the cumulative amount of insulin released from TMC/gamma-PGA NPs was significantly reduced.	poly(gamma-glutamic acid)	14-23	insulin	Homo sapiens	82-89